Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

1999 • 967 citations

Biochemical pathophysiology of Parkinson's disease.

1987 • 844 citations

Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles

2000 • 432 citations

Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study

1992 • 423 citations

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

2001 • 381 citations

Enzymatic Oxidation of Dopamine: The Role of Prostaglandin H Synthase

1995 • 349 citations

PHASE AND ELECTRON MICROSCOPIC OBSERVATIONS OF LEWY BODIES AND MELANIN GRANULES IN THE SUBSTANTIA NIGRA AND LOCUS CAERULEUS IN PARKINSONʼS DISEASE

1965 • 330 citations

Iron‐Melanin Complex in Substantia Nigra of Parkinsonian Brains: An X‐Ray Microanalysis

1992 • 308 citations

Activation of microglia by human neuromelanin is NF‐κB‐dependent and involves p38 mitogen‐activated protein kinase: implications for Parkinson's disease

2003 • 303 citations

Selectivity of the Parkinsonian Neurotoxin MPTP: Toxic Metabolite MPP ⁺ Binds to Neuromelanin

1986 • 289 citations

The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease

2001 • 263 citations

Is the Vulnerability of Neurons in the Substantia Nigra of Patients with Parkinson's Disease Related to Their Neuromelanin Content?

1992 • 221 citations

On the origin and significance of neuromelanin.

1979 • 221 citations

Tyrosine mRNA is expressed in human substantia nigra

1997 • 197 citations

Interaction of neuromelanin and iron in substantia nigra and other areas of human brain

1996 • 192 citations

The structure of neuromelanin as studied by chemical degradative methods

2003 • 166 citations

Iron and Other Metals in Neuromelanin, Substantia Nigra, and Putamen of Human Brain

1994 • 162 citations

Occurrence and distribution of 5-S-cysteinyl derivatives of dopamine, dopa and dopac in the brains of eight mammalian species

1986 • 152 citations

On the Nature of Pigment Granules in the Cells of the Locus Coeruleus and Substantia Nigra

1958 • 129 citations

The effect of a synthetic neuromelanin on yield of free hydroxyl radicals generated in model systems

1995 • 128 citations

Binding of Iron to Neuromelanin of Human Substantia Nigra and Synthetic Melanin: An Electron Paramagnetic Resonance Spectroscopy Study

1997 • 127 citations

Structural Characteristics of Human Substantia Nigra Neuromelanin and Synthetic Dopamine Melanins

2000 • 114 citations

Autoradiography of [14C]paraquat or [14C]diquat in frogs and mice: Accumulation in neuromelanin

1988 • 112 citations

Pigmentation in the nucleus substantiae nigrae of mammals.

1961 • 108 citations

New evidence for presence of tyrosinase in substantia nigra, forebrain and midbrain

1998 • 103 citations

Interaction of Human Substantia Nigra Neuromelanin with Lipids and Peptides

2000 • 94 citations

Enzyme Activity of Macrophage Migration Inhibitory Factor toward Oxidized Catecholamines

1999 • 82 citations

The structure of neuromelanin and its iron binding site studied by infrared spectroscopy

1999 • 79 citations

Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?

1998 • 74 citations

Neuromelanin of the Human Substantia Nigra: A Mixed‐Type Melanin

1994 • 73 citations

Studies on neuromelanin

1968 • 57 citations

Q-band EPR investigations of neuromelanin in control and Parkinson’s disease patients

2000 • 51 citations

Neuromelanic pigment in substantia nigra neurons of rats and dogs

1986 • 47 citations

Binding of dopaminergic drugs by the neuromelanin of the substantia nigra, synthetic melanins and melanin granules.

1978 • 33 citations

MELANOGENESIS AND EXTRAPYRAMIDAL DISEASES.

1964 • 28 citations