Influence of chemical and ischemic preconditioning on cytokine expression after focal brain ischemia

Reversible middle cerebral artery occlusion without craniectomy in rats.

1989 • 6,875 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Tumor Necrosis Factor-α

1997 • 864 citations

Proinflammatory Cytokines and Early Neurological Worsening in Ischemic Stroke

2000 • 655 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene Expression

1998 • 488 citations

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

1999 • 472 citations

CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

1999 • 435 citations

Early Intrathecal Production of Interleukin-6 Predicts the Size of Brain Lesion in Stroke

1995 • 375 citations

TNF-α Pretreatment Induces Protective Effects against Focal Cerebral Ischemia in Mice

1997 • 346 citations

Stress Proteins and Tolerance to Focal Cerebral Ischemia

1996 • 298 citations

Inflammatory Signals Induce Neurotrophin Expression in Human Microglial Cells

1998 • 285 citations

Increased Expression of TGF-β1 in Brain Tissue After Ischemic Stroke in Humans

1996 • 275 citations

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

1996 • 262 citations

Ischemic and Excitotoxic Brain Injury is Enhanced in Mice Lacking the p55 Tumor Necrosis Factor Receptor

1998 • 254 citations

Cytokines ‐ killers in the brain?

1999 • 251 citations

Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat

1996 • 247 citations

Inflammation-Mediated Damage in Progressing Lacunar Infarctions

2002 • 238 citations

Induction of interleukin-1β mRNA after focal cerebral ischaemia in the rat

1994 • 236 citations

Interleukin-1 β and tumor necrosis factor-α synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes

1990 • 233 citations

The Progression and Topographic Distribution of Interleukin-1β Expression after Permanent Middle Cerebral Artery Occlusion in the Rat

1999 • 228 citations

Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke

2001 • 211 citations

TGF-β1 Protects Hippocampal Neurons Against Degeneration Caused by Transient Global Ischemia

1996 • 202 citations

Interleukin-1 Mediates Induction of Tolerance to Global Ischemia in Gerbil Hippocampal CA1 Neurons

1996 • 198 citations

Inhibition of Tumor Necrosis Factor and Amelioration of Brain Infarction in Mice

1997 • 190 citations

Early TNF-α levels correlate with ischaemic stroke severity

2001 • 187 citations

Proteasome Inhibitor PS519 Reduces Infarction and Attenuates Leukocyte Infiltration in a Rat Model of Focal Cerebral Ischemia

2000 • 183 citations

Expression of Interleukin-6, c-Fos, and zif268 mRNAs in Rat Ischemic Cortex

1995 • 179 citations

Lack of Interleukin-6 Expression Is Not Protective Against Focal Central Nervous System Ischemia

2000 • 179 citations

Cortical Spreading Depression Induces Proinflammatory Cytokine Gene Expression in the Rat Brain

2001 • 166 citations

Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-α and ceramide

2000 • 165 citations

Benign focal ischemic preconditioning induces neuronal Hsp70 and prolonged astrogliosis with expression of Hsp27

2000 • 153 citations

Respiratory Chain Inhibition Induces Tolerance to Focal Cerebral Ischemia

1999 • 146 citations

Fas/CD95/APO‐1 Can Function as a Death Receptor for Neuronal Cells in Vitro and in Vivo and is Upregulated Following Cerebral Hypoxic‐Ischemic Injury to the Developing Rat Brain

2000 • 144 citations

Stroke in Estrogen Receptor-α–Deficient Mice

2000 • 144 citations

TNF-α–Induced Tolerance to Ischemic Injury Involves Differential Control of NF-κB Transactivation: The Role of NF-κB Association with p300 Adaptor

2002 • 140 citations

Global Forebrain Ischemia Results in Differential Cellular Expression of Interleukin-1β (IL-1β) and its Receptor at mRNA and Protein Level

1997 • 131 citations

Attenuation of Ischemic Brain EDEMA and Cerebrovascular Injury after Ischemic Preconditioning in the Rat

2001 • 124 citations

bcl-2 Antisense Treatment Prevents Induction of Tolerance to Focal Ischemia in the Rat Brain

2001 • 111 citations

Preferential Conditions for and Possible Mechanisms of Induction of Ischemic Tolerance by Repeated Hyperbaric Oxygenation in Gerbil Hippocampus

2001 • 98 citations

Differential role of nitric oxide pathway and heat shock protein in preconditioning and lipopolysaccharide-induced brain ischemic tolerance

2000 • 96 citations

Transforming growth factor-β1 exhibits delayed gene expression following focal cerebral ischemia

1995 • 93 citations

Quantitative changes in interleukin proteins following focal stroke in the rat

2000 • 90 citations

Prolonged and concomitant induction of astroglial immunoreactivity of interleukin-1beta and interleukin-6 in the rat hippocampus after transient global ischemia

1999 • 86 citations

Intrathecal Expression of Proteins Regulating Apoptosis in Acute Stroke

1999 • 86 citations

Cortical spreading depression induces long-term alterations of BDNF levels in cortex and hippocampus distinct from lesion effects: implications for ischemic tolerance

1997 • 85 citations

Application of real-time polymerase chain reaction to quantitate induced expression of interleukin-1? mRNA in ischemic brain tolerance

2000 • 76 citations

Localization of Fas antigen mRNA induced in postischemic murine forebrain by in situ hybridization

1995 • 75 citations

Evolutionary Origins of the Transforming Growth Factor-β Gene Family

1992 • 71 citations

Detection of Tumor Necrosis Factor-α mRNA Induction in Ischemic Brain Tolerance by Means of Real-Time Polymerase Chain Reaction

2000 • 61 citations

Upregulation of TACE/ADAM17 after Ischemic Preconditioning is Involved in Brain Tolerance

2002 • 58 citations

Subchronic glucocorticoid pretreatment reversibly attenuates IL-1β induced fever in rats; IL-6 mRNA is elevated while IL-1α and IL-1β mRNAs are suppressed, in the CNS

1996 • 38 citations

Differential Regulation of IL-1β and TNF-α RNA Expression by MEK1 Inhibitor after Focal Cerebral Ischemia in Mice

2001 • 34 citations

Cytokine Responses in Patients Undergoing Coronary Artery Bypass Surgery after Ischemic Preconditioning

2001 • 21 citations