The Rac and Rho pathways as a source of drug targets for Ras-mediated malignancies

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

1994 • 749 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

1995 • 542 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins

1994 • 518 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Post-translational modifications of p21rho proteins.

1992 • 422 citations

Identification of a Mouse p21Cdc42/Rac Activated Kinase

1995 • 395 citations

GTPase cascades choreographing cellular behavior: Movement, morphogenesis, and more

1995 • 394 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

The activation of phosphatidylinositol 3-kinase by Ras

1994 • 322 citations

Cooperative interaction of S. pombe proteins required for mating and morphogenesis

1994 • 303 citations

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

1994 • 287 citations

Activation of rat liver phospholipase D by the small GTP-binding protein RhoA

1994 • 265 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA.

1992 • 228 citations

Lysophosphatidic acid signalling

1995 • 223 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho.

1993 • 211 citations

Interactions among Proteins Involved in Bud-site Selection and Bud-site Assembly in Saccharomyces cerevisiae

1995 • 209 citations

Rac mediates growth factor-induced arachidonic acid release

1995 • 207 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Transformation suppressor activity of a Jun transcription factor lacking its activation domain

1991 • 190 citations

Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

1995 • 188 citations

ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle.

1993 • 186 citations

Membrane ruffling and signal transduction

1994 • 183 citations

Expression Cloning of Oncogenes by Retroviral Transfer of cDNA Libraries

1995 • 178 citations

Rho-related proteins: actin cytoskeleton and cell cycle

1995 • 176 citations

Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene.

1993 • 175 citations

Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.

1995 • 170 citations

Matrix Metalloproteinase Gene Expression^a

1994 • 156 citations

Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function

1995 • 156 citations

Suppression of tumorigenicity in simian virus 40-transformed 3T3 cells transfected with alpha-actinin cDNA.

1993 • 156 citations

Growth-regulated expression of rhoG, a new member of the ras homolog gene family.

1992 • 114 citations

The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.

1994 • 113 citations

Tumorigenic activity of rho genes from Aplysia californica.

1993 • 108 citations

Characterization and expression of the human rhoH12 gene product.

1989 • 108 citations

Ras signaling and NF1

1995 • 100 citations

Regulation of Ras-related RhoB protein expression during the cell cycle.

1995 • 84 citations

Different structural organization of Ras and Rho effector domains.

1993 • 83 citations

Phosphoinositide 3-Kinase as an Upstream Regulator of the Small GTP-Binding Protein Rac in the Insulin Signaling of Membrane Ruffling

1995 • 78 citations

Actin, its associated proteins and metastasis

1995 • 77 citations

Reversion of Ras transformed cells by Ets transdominant mutants.

1994 • 69 citations

Inhibition of Fos- and Ras-induced transformation by mutant Fos proteins with structural alterations in functionally different domains.

1992 • 29 citations