Do genetics play a role in the pathogenesis of asthma?

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

A genome-wide search for quantitative trait loci underlying asthma

1996 • 797 citations

Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy

1995 • 774 citations

A genome-wide search for asthma susceptibility loci in ethnically diverse populations

1997 • 712 citations

LINKAGE BETWEEN IMMUNOGLOBULIN E RESPONSES UNDERLYING ASTHMA AND RHINITIS AND CHROMOSOME 11q

1989 • 624 citations

Genetics of Asthma and Hay Fever in Australian Twins

1990 • 510 citations

ALLERGY IN 7000 TWIN PAIRS

1971 • 418 citations

Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor

1994 • 406 citations

National asthma education program expert panel report. Guidelines for the diagnosis and management of asthma

1991 • 397 citations

Evidence for a Locus Regulating Total Serum IgE Levels Mapping to Chromosome 5

1994 • 395 citations

Linkage of Asthma and Total Serum IgE Concentration to Markers on Chromosome 12q: Evidence from Afro-Caribbean and Caucasian Populations

1996 • 226 citations

Genetic linkage of T-cell receptor $alpha;/$delta; complex to specific IgE responses

1994 • 219 citations

Genetic Control of Basal Serum Immunoglobulin E Level and Its Effect on Specific Reaginic Sensitivity

1974 • 200 citations

HLA‐DR and HLA‐DP genotypes and immunoglobulin E responses to common major allergens

1994 • 158 citations

Genetic Factors in Nonspecific Bronchial Hyperreactivity

1987 • 113 citations

Segregation analysis of bronchial response to methacholine inhalation challenge in families with and without asthma

1986 • 111 citations

Factors influencing the prevalence of asthma among first degree relatives of extrinsic and intrinsic asthmatics.

1979 • 97 citations

Evidence for two unlinked loci regulating total serum IgE levels.

1995 • 92 citations

HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy.

1992 • 87 citations

Bronchial reactivity pattern in nonasthmatic parents of asthmatics.

1988 • 71 citations

Evidence for Mendelian inheritance of serum IgE levels in Hispanic and non-Hispanic white families.

1994 • 70 citations

Molecular Studies of Human Response to Allergens

1989 • 37 citations

The genetics of atopy

1994 • 15 citations

Ragweed sensitivity: segregation analysis and linkage to <i>HLA-</i><i>B</i>

1978 • 11 citations