Specificity of mutations in the PMS2-deficient human tumor cell line HEC-1-A

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

1996 • 541 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

1995 • 521 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

1995 • 403 citations

hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

1996 • 363 citations

Identification of mismatch repair genes and their role in the development of cancer

1995 • 319 citations

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

1995 • 239 citations

DNA‐replication Fidelity, Mismatch Repair and Genome Instability in Cancer Cells

1996 • 209 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2

1997 • 153 citations

Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects

1997 • 148 citations

Conditional Mutator Phenotypes in hMSH2-Deficient Tumor Cell Lines

1997 • 99 citations

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

1996 • 90 citations

A hPMS2 Mutant Cell Line Is Defective in Strand-specific Mismatch Repair

1995 • 89 citations

Molecular analysis of mutations in mutator colorectal carcinoma cell lines

1995 • 86 citations

Software for the analysis of mutations at the human hprt gene

1994 • 62 citations

Mismatch repair in extracts of Werner syndrome cell lines.

1997 • 59 citations

Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair

1997 • 53 citations