Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

Inducible Gene Targeting in Mice

1995 • 1,897 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1999 • 1,091 citations

The INK4a/ARF network in tumour suppression

2001 • 956 citations

Granulocytic sarcoma: A clinicopathologic study of 61 biopsied cases

1981 • 956 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

Targeted oncogene activation by site-specific recombination in transgenic mice.

1992 • 687 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

Molecular Cloning and Characterization of PEBP2β, the Heterodimeric Partner of a Novel Drosophila runt-Related DNA Binding Protein PEBP2α

1993 • 504 citations

AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

2000 • 464 citations

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

2001 • 426 citations

Cloning and Characterization of Subunits of the T-Cell Receptor and Murine Leukemia Virus Enhancer Core-Binding Factor

1993 • 425 citations

Biallelic and Heterozygous Point Mutations in the Runt Domain of theAML1/PEBP2B Gene Associated With Myeloblastic Leukemias

1999 • 408 citations

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

1996 • 382 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 362 citations

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

1997 • 362 citations

C-kit mutations in core binding factor leukemias

2000 • 311 citations

Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long-term remission

1993 • 297 citations

Expression of a Knocked-In AML1-ETO Leukemia Gene Inhibits the Establishment of Normal Definitive Hematopoiesis and Directly Generates Dysplastic Hematopoietic Progenitors

1998 • 280 citations

High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in Mo acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21

2000 • 265 citations

8;21 translocation in acute granulocytic leukaemia: cytological, cytochemical and clinical features

1984 • 248 citations

Granulocytic sarcoma is associated with the 8;21 translocation in acute myeloid leukemia.

1993 • 235 citations

Retroviral-Mediated Transfer of the Green Fluorescent Protein Gene Into Murine Hematopoietic Cells Facilitates Scoring and Selection of Transduced Progenitors In Vitro and Identification of Genetically Modified Cells In Vivo

1997 • 230 citations

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor.

1993 • 229 citations

THE AML1‐ETO CHIMAERIC TRANSCRIPTION FACTOR IN ACUTE MYELOID LEUKAEMIA: BIOLOGY AND CLINICAL SIGNIFICANCE

1999 • 214 citations

Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia

1996 • 203 citations

Associations between morphology, karyotype, and clinical features in myeloid leukemias

1987 • 154 citations

Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis

2000 • 151 citations

Dichotomy of AML1-ETO Functions: Growth Arrest versus Block of Differentiation

2001 • 148 citations

Core-binding factor: a central player in hematopoiesis and leukemia.

1999 • 118 citations

Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP‐mediated recombination in the mouse

2000 • 109 citations

Differential effects of p19^Arfand p16^Ink4aloss on senescence of murine bone marrow-derived preB cells and macrophages

2001 • 105 citations

Leukemogenesis by CBF oncoproteins

1999 • 97 citations

Cytologic characterization and significance of normal karyotypes in t(8;21) acute myeloblastic leukemia

1982 • 97 citations

Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras.

1991 • 70 citations

Alterations of the AML1 transcription factor in human leukemia

2000 • 61 citations

Myeloblastoma with an 8;21 chromosome translocation in acute myeloblastic leukemia

1986 • 41 citations

Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins

2001 • 41 citations

Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2

1999 • 36 citations

Additional translocation (8;21)(q22;q22) in a patient with Philadelphia‐positive chronic myelogenous leukaemia in the blastic phase

1999 • 31 citations

Granulocytic Sarcoma (chloroma): Presentation of an Unusual Case

1991 • 30 citations

Clinical Heterogeneity in Acute Myelogenous Leukemia with the 8;21 Translocation.

1991 • 12 citations

Expression of AML1/MTG8 transcripts in clonogenic cells grown from bone marrow of patients in remission of acute myeloid leukaemia with t(8;21)

1997 • 11 citations