Protein kinase C mediates mutant N-Ras–induced developmental abnormalities in normal human erythroid cells

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C

1991 • 2,499 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

1996 • 602 citations

New insights into the regulation of protein kinase C and novel phorbol ester receptors

1999 • 600 citations

Multiple pathways control protein kinase C phosphorylation

2000 • 598 citations

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways

2000 • 572 citations

Loss of The Normal NF1 Allele from the Bone Marrow of Children with Type 1 Neurofibromatosis and Malignant Myeloid Disorders

1994 • 456 citations

Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: a multivariate analysis of prognostic factors in 370 patients

1989 • 412 citations

High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein.

1998 • 357 citations

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1995 • 261 citations

Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.

1990 • 259 citations

Characterization of a bipotent erythro-megakaryocytic progenitor in human bone marrow

1996 • 258 citations

Ras proteins in the control of the cell cycle and cell differentiation

2000 • 185 citations

Genetic analysis is consistent with the hypothesis that NF1 limits myeloid cell growth through p21ras

1994 • 172 citations

Ras Proteins: Recent Advances and New Functions

1999 • 140 citations

Purification, amplification and characterization of a population of human erythroid progenitors

1999 • 112 citations

Protein Kinase Cι Activity Is Necessary for Bcr-Abl-mediated Resistance to Drug-induced Apoptosis

1999 • 111 citations

Mutant N-ras Induces Myeloproliferative Disorders and Apoptosis in Bone Marrow Repopulated Mice

1999 • 110 citations

Selective Involvement Of Protein Kinase C Isozymes In Differentiation And Neoplastic Transformation

1994 • 104 citations

Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes.

1990 • 103 citations

Human monomyeloid cell membrane antigens.

1990 • 102 citations

Erythropoietin-Induced Activation of STAT5 Is Impaired in the Myelodysplastic Syndrome

1997 • 98 citations

Integrin expression profiles during erythroid differentiation

1992 • 95 citations

Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates

2001 • 83 citations

Protein Kinase C α Controls Erythropoietin Receptor Signaling

2000 • 79 citations

The αIIbβ3 integrin and GPIb-V-IX complex identify distinct stages in the maturation of CD34+cord blood cells to megakaryocytes

2000 • 78 citations

Mutant N-RAS Induces Erythroid Lineage Dysplasia in Human CD34+ Cells

1997 • 73 citations

The molecular basis of myelodysplastic syndromes.

1997 • 67 citations

Lineage commitment of transformed haematopoietic progenitors is determined by the level of PKC activity.

1996 • 66 citations

Protein kinase C-α isoform is involved in erythropoietin-induced erythroid differentiation of CD34+ progenitor cells from human bone marrow

2000 • 65 citations

Up-regulation of surface CD34 is associated with protein kinase C-mediated hyperphosphorylation of CD34.

1992 • 62 citations

Role of Cytokine Signaling Molecules in Erythroid Differentiation of Mouse Fetal Liver Hematopoietic Cells: Functional Analysis of Signaling Molecules by Retrovirus-Mediated Expression

1999 • 58 citations

Phorbol ester treatment of U937 cells with altered protein kinase C content and distribution induces cell death rather than differentiation.

1995 • 56 citations

Abnormal erythroid progenitor cells in human preleukemia

1982 • 55 citations

Expression of Novel Surface Antigens on Early Hematopoietic Cells^a

1999 • 55 citations

Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines

2000 • 53 citations

A Potential Role for Protein Kinase C-ε in Regulating Megakaryocytic Lineage Commitment

2001 • 52 citations

Modulation of p210BCR-ABL activity in transduced primary human hematopoietic cells controls lineage programming

2002 • 51 citations

Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line

1995 • 50 citations

An Activated Protein Kinase C α Gives a Differentiation Signal for Hematopoietic Progenitor Cells and Mimicks Macrophage Colony-stimulating Factor–stimulated Signaling Events

1998 • 50 citations

Lineage-Restricted Expression of Protein Kinase C Isoforms in Hematopoiesis

1999 • 44 citations

The role of serine/threonine phosphorylation in hematopoietic cytokine receptor signal transduction

1997 • 42 citations

Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentiation of IL-3–dependent myeloid progenitor cells

2000 • 41 citations

Erythropoiesis in myelodysplastic syndrome: expression of receptors for erythropoietin and kit ligand.

1996 • 40 citations

Prognostic value of c-mpl expression in myelodysplastic syndromes.

1995 • 39 citations

Differential Expression of Protein Kinase C Isoform Transcripts in Human Hematopoietic Progenitors Undergoing Differentiation

1999 • 38 citations

Mutations and Expression of the ras Family Genes in Leukemias

1996 • 34 citations

Ras effectors: Buying shares in Ras plc

2001 • 31 citations

Growth Factor-Independent Proliferation of Erythroid Cells Infected with Friend Spleen Focus-Forming Virus Is Protein Kinase C Dependent but Does Not Require Ras-GTP

2000 • 29 citations

Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a protein kinase C-dependent process.

1998 • 27 citations

Upregulation of CD9 expression during TPA treatment of K562 cells

1997 • 22 citations

Induction of Megakaryocytic Differentiation in Primary Human Erythroblasts

2001 • 18 citations

Protein kinase C in erythroid and megakaryocytic differentiation: possible role in lineage determination

1997 • 18 citations

Expression of CD41 and c‐mpl does not indicate commitment to the megakaryocyte lineage during haemopoietic development

1999 • 17 citations

Aberrant expression of p21RAS but not p120GAP is a common feature of myelodysplasia.

1995 • 16 citations

Selective modulation of specific protein kinase C (PKC) isoforms in primary human megakaryocytic vs. erythroid cells

1999 • 15 citations

CD34+/CD36− cells from myelodysplasia patients have a limited capacity to proliferate but can differentiate in response to Epo and MGF stimulation

1998 • 13 citations

Abnormal erythroid progenitor cells in human preleukemia

1982 • 2 citations