Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor.

Cloning and expression of human tissue-type plasminogen activator cDNA in E. coli

1983 • 1,241 citations

Synthesis of fibrinolytic activator and inhibitor by endothelial cells

1977 • 484 citations

Evidence for a rapid inhibitor to tissue plasminogen activator in plasma

1983 • 479 citations

Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells.

1983 • 400 citations

Evidence for the Occurrence of a Fast-Acting Inhibitor for Tissue-Type Plasminogen Activator in Human Plasma

1984 • 345 citations

Heparin cofactor activity measured with an amidolytic method

1975 • 341 citations

Relationship between tissue plasminogen activator and the activators in blood and vascular wall

1980 • 254 citations

Latent tissue plasminogen activator produced by human endothelial cells in culture: evidence for an enzyme-inhibitor complex.

1983 • 250 citations

Plasma levels of a specific inhibitor of tissue-type plasminogen activator (and urokinase) in normal and pathological conditions

1984 • 240 citations

Defective fibrinolysis in blood and vein walls in recurrent "idiopathic" venous thrombosis.

1972 • 206 citations

Determination of a new rapid plasmin inhibitor in human blood by means of a plasmin specific tripeptide substrate

1977 • 206 citations

The role of the fibrinolytic system in deep vein thrombosis.

1985 • 201 citations

On fibrinolysis induced by streptokinase in man

1962 • 161 citations

Severe Thrombotic Disease in a Young Man with Bone Marrow and Skeletal Changes and with a High Content of an Inhibitor in the Fibrinolytic System

1961 • 155 citations

Clinical Relevance of Antithrombin III

1982 • 134 citations

Haemorrhagic and Thrombotic Diseases.

1975 • 128 citations

Antithrombin III in a clinical material

1973 • 114 citations

An inhibitor from placenta specifically binds urokinase and inhibits plasminogen activator released from ovarian carcinoma in tissue culture

1978 • 110 citations

Comparative studies of the fibrinolytic activity of cultured vascular cells

1979 • 101 citations

Inhibition of tissue-type plasminogen activator by conditioned medium from cultured human and porcine vascular endothelial cells

1983 • 99 citations

Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor

1983 • 93 citations

A Family with Thromboembolic Disease Associated with Deficient Fibrinolytic Activity in Vessel Wall

1978 • 87 citations

Two Genetic Variants of von Willebrand's Disease

1973 • 86 citations

"Fibrinolytic capacity" in healthy volunteers as estimated from effect of venous occlusion of arms.

1972 • 80 citations

Clinical Studies of Protein C

1984 • 68 citations

Impairment of the Diurnal Fibrinolytic Response in Man

1973 • 68 citations

A Family with Reduced Plasminogen Activator Activity in Blood Associated with Recurrent Venous Thrombosis

1982 • 55 citations

Modulation of Rapid Plasminogen Activator Inhibitor in Plasma by Stanozolol

1984 • 53 citations

Deep venous thrombosis of the arm: a study of coagulation and fibrinolysis.

1981 • 50 citations

Differential inhibition of two molecular forms of melanoma cell plasminogen activator by a placental inhibitor

1984 • 46 citations

Studies of the Blood Plasminogen Activator Induced by 1-Desamino-8-D-arginine Vasopressin with Observations in von Willebrand's Disease

1982 • 42 citations

On release and synthesis of fibrinolytic activators in human organ culture.

1972 • 36 citations

Immunological characterisation of plasminogen activators in the human vessel wall.

1983 • 28 citations

Coagulation, fibrinolysis and venous thrombosis.

1977 • 10 citations

Plasminogen activator activity of superficial veins in acute deep venous thrombosis.

1982 • 8 citations

[Study of coagulation and fibrinolysis in 131 cases of recurrent deep vein thrombosis].

1982 • 7 citations

[A family with reduced plasminogen activator activity in the blood associated with recurrent thrombosis].

1983 • 5 citations