Role of the α2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

1997 • 4,191 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

1997 • 2,784 citations

[99] Determination of nucleic acids in tissues by pentose analysis

1957 • 1,906 citations

Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix

1990 • 1,546 citations

Distinct proliferative and differentiated stages of murine MC3T3-E1 cells in culture: An in vitro model of osteoblast development

1992 • 949 citations

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

1993 • 621 citations

Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia

1997 • 574 citations

Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells

1992 • 538 citations

Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex

1997 • 441 citations

Effects of ascorbic acid on collagen matrix formation and osteoblast differentiation in murine MC3T3-E1 cells

1994 • 431 citations

AML1, AML2, and AML3, the Human Members of the runt domain Gene-Family: cDNA Structure, Expression, and Chromosomal Localization

1994 • 403 citations

Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen.

1991 • 401 citations

Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones.

1986 • 398 citations

Expression of differentiated function by mineralizing cultures of chicken osteoblasts

1987 • 397 citations

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

1996 • 382 citations

Integrin α2β1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells

1991 • 379 citations

Bone matrix RGD glycoproteins: Immunolocalization and interaction with human primary osteoblastic bone cells in vitro

1994 • 366 citations

Fibronectin regulates calvarial osteoblast differentiation

1996 • 301 citations

Differentiation and Transforming Growth Factor-β Receptor Down-regulation by Collagen-α2β1 Integrin Interaction Is Mediated by Focal Adhesion Kinase and Its Downstream Signals in Murine Osteoblastic Cells

1997 • 289 citations

Integrin α2β1 Is a Positive Regulator of Collagenase (MMP-1) and Collagen α1(I) Gene Expression

1995 • 281 citations

Integrin expression in human bone

1993 • 256 citations

Integrin Expression and Function on Human Osteoblast-like Cells

1997 • 248 citations

Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts

1997 • 243 citations

Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture

1992 • 237 citations

Regulation of human osteoblast integrin expression by orthopedic implant materials

1996 • 203 citations

Differentiation and Cell Surface Expression of Transforming Growth Factor-β Receptors Are Regulated by Interaction with Matrix Collagen in Murine Osteoblastic Cells

1996 • 203 citations

Ascorbic Acid-Dependent Activation of the Osteocalcin Promoter in MC3T3-E1 Preosteoblasts: Requirement for Collagen Matrix Synthesis and the Presence of an Intact OSE2 Sequence

1997 • 187 citations

The Extracellular Signal-Regulated Kinase Pathway Phosphorylates AML1, an Acute Myeloid Leukemia Gene Product, and Potentially Regulates Its Transactivation Ability

1996 • 153 citations

Bone matrix mRNA expression in differentiating fetal bovine osteoblasts

1992 • 141 citations

The Role of Ascorbic Acid in Mesenchymal Differentiation

2009 • 140 citations

1,25-Dihydroxyvitamin D3 Inhibits Osteocalcin Expression in Mouse through an Indirect Mechanism

1997 • 113 citations

Functional Hierarchy between Two OSE2 Elements in the Control of Osteocalcin Gene Expression in Vivo

1998 • 104 citations

Murine bone sialoprotein (BSP): cDNA cloning, mRNA expression, and genetic mapping

1994 • 96 citations

Collagen-stimulated induction of keratinocyte collagenase is mediated via tyrosine kinase and protein kinase C activities.

1994 • 94 citations

Complex patterns of expression suggest extensive roles for the α₂β₁ integrin in murine development

1994 • 91 citations

PTH/PTHrP receptor is temporally regulated during osteoblast differentiation and is associated with collagen synthesis

1996 • 81 citations

Mineralization of bone-like extracellular matrix in the absence of functional osteoblasts

1995 • 78 citations

Synthetic peptide containing Arg-Gly-Asp inhibits bone formation and resorption in a mineralizing organ culture system of fetal rat parietal bones

1994 • 77 citations

Fibronectin gene expression, synthesis, and accumulation during in vitro differentiation of chicken osteoblasts

1995 • 74 citations

Ribosomal DNA of the fly Sciara coprophila has a very small and homogeneous repeat unit

1979 • 69 citations

The α2β1 integrin regulates collagen-mediated mdck epithelial membrane remodeling and tubule formation

1995 • 60 citations

Regulation and Properties of Bone Alkaline Phosphatase during Vitamin C Deficiency in Guinea Pigs

1996 • 34 citations

Three-Dimensional Contact with Type I Collagen Mediates Tyrosine Phosphorylation in Primary Human Fibroblasts

1994 • 34 citations

Alteration of Bone Status with Ascorbic Acid Deficiency in ODS (Osteogenic Disorder Shionogi) Rats

1995 • 29 citations