Use of binding energy in catalysis analyzed by mutagenesis of the tyrosyl-tRNA synthetase

Enzyme structure and mechanism

1977 • 2,935 citations

Hydrogen bonding and biological specificity analysed by protein engineering

1985 • 1,050 citations

Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

1975 • 844 citations

Molecular Architecture and Biological Reactions

1946 • 835 citations

The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)

1984 • 563 citations

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

1982 • 348 citations

Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation

1983 • 268 citations

Catalysis, binding and enzyme-substrate complementarity

1974 • 222 citations

Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.

1985 • 179 citations

Analysis of Enzyme Structure and Activity by Protein Engineering

1984 • 97 citations

Probing histidine-substrate interactions in tyrosyl-tRNA synthetase using asparagine and glutamine replacements

1985 • 88 citations

Ligand binding and enzymic catalysis coupled through subunits in tyrosyl-tRNA synthetase

1975 • 88 citations

Hydrogen bonding in enzymatic catalysis analysed by protein engineering

1985 • 78 citations

Editing mechanisms in aminoacylation of tRNA:ATP consumption and the binding of aminoacyl-tRNA by elongation factor Tu

1977 • 49 citations

Fine structure-activity analysis of mutations at position 51 of tyrosyl-tRNA synthetase

1985 • 31 citations

Interaction of crystalline tyrosyl-tRNA synthetase with adenosine, adenosine monophosphate, adenosine triphosphate and pyrophosphate in the presence of tyrosinol

1984 • 14 citations