Response of a Protein Structure to Cavity-Creating Mutations and Its Relation to the Hydrophobic Effect

Dominant forces in protein folding

1990 • 3,682 citations

Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

AREAS, VOLUMES, PACKING, AND PROTEIN STRUCTURE

1977 • 2,631 citations

The hydrophobic effect

1980 • 1,922 citations

The Solubility of Amino Acids and Two Glycine Peptides in Aqueous Ethanol and Dioxane Solutions

1971 • 1,417 citations

Protein stability curves

1987 • 990 citations

Hydrophobic bonding and accessible surface area in proteins

1974 • 887 citations

An efficient general-purpose least-squares refinement program for macromolecular structures

1987 • 871 citations

Hydrophobic parameters π of amino-acid side chains from the partitioning of N-acetyl-amino-acid amides.

1983 • 705 citations

Reconciling the Magnitude of the Microscopic and Macroscopic Hydrophobic Effects

1991 • 509 citations

[3] Expression and nitrogen-15 labeling of proteins for proton and nitrogen-15 nuclear magnetic resonance

1989 • 455 citations

Extracting hydrophobic free energies from experimental data: relationship to protein folding and theoretical models

1991 • 431 citations

Thermodynamics of protein denaturation. III. Denaturation of ribonuclease in water and in aqueous urea and aqueous ethanol mixtures

1967 • 422 citations

Contribution of hydrophobic interactions to protein stability

1988 • 413 citations

Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3

1988 • 375 citations

Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease

1990 • 372 citations

Structure of bacteriophage T4 lysozyme refined at 1.7 Å resolution

1987 • 349 citations

Energetics of complementary side chain packing in a protein hydrophobic core

1989 • 346 citations

Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme

1991 • 265 citations

Temperature-sensitive mutations of bacteriophage T4 lysozyme occur at sites with low mobility and low solvent accessibility in the folded protein

1987 • 253 citations

Stabilization of phage T4 lysozyme by engineered disulfide bonds.

1989 • 245 citations

Genetic and structural analysis of the protein stability problem

1987 • 227 citations

Disulfide bonds and thermal stability in T4 lysozyme.

1988 • 165 citations

Partitioning of nonpolar solutes into bilayers and amorphous n-alkanes

1990 • 145 citations

Replacements of Pro ⁸⁶ in Phage T4 Lysozyme Extend an α-Helix But Do Not Alter Protein Stability

1988 • 131 citations

Energetics of repacking a protein interior.

1991 • 111 citations

Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft

1991 • 104 citations

Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine.

1990 • 101 citations

[27] Structure and thermal stability of phage T4 lysozyme

1987 • 91 citations

Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine.

1990 • 89 citations

An oscillation data collection system for high-resolution protein crystallography

1981 • 84 citations

A mutant T4 lysozyme (Val 131 → Ala) designed to increase thermostability by the reduction of strain within an α‐helix

1990 • 83 citations

Structural and thermodynamic analysis of the packing of two α-helices in bacteriophage T4 lysozyme

1991 • 78 citations

Structural Studies of Mutants of T4 Lysozyme That Alter Hydrophobic Stabilization

1989 • 67 citations

The role of solvent polarity in the free energy of transfer of amino acid side chains from water to organic solvents.

1986 • 61 citations

The hydrophobic effect

1991 • 42 citations