Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene

1984 • 955 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

1995 • 865 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

1994 • 777 citations

Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4

1985 • 702 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

MECHANISMS UNDERLYING EXPRESSION OF TN10 ENCODED TETRACYCLINE RESISTANCE

1994 • 508 citations

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

1995 • 383 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

Conditional transformation of a pancreatic beta-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene.

1995 • 259 citations

Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements

1993 • 233 citations

Regulation of cytomegalovirus gene expression: alpha and beta promoters are trans activated by viral functions in permissive human fibroblasts

1985 • 229 citations

Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector.

1994 • 157 citations

Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene.

1993 • 150 citations

The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component

1986 • 149 citations

[35] Transient expression analysis in plants using firefly luciferase reporter gene

1992 • 147 citations

The Responsiveness of a Tetracycline-sensitive Expression System Differs in Different Cell Lines

1995 • 112 citations

Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells

1993 • 107 citations

Structural requirements of tetracycline-Tet repressor interaction: determination of equilibrium binding constants for tetracycline analogs with the Tet repressor

1991 • 103 citations

Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss.

1995 • 95 citations

Inducible vectors for expression in mammalian cells

1992 • 95 citations

Overexpression of the Glucose Transporter Gene with a Herpes Simplex Viral Vector Protects Striatal Neurons against Stroke

1996 • 94 citations

Regulated expression of foreign genes in vivo after germline transfer.

1994 • 86 citations

Evidence that tetracycline analogs whose primary target is not the bacterial ribosome cause lysis of Escherichia coli

1992 • 82 citations

Efficacy of tetracycline-controlled gene expression is influenced by cell type.

1995 • 79 citations

Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the β-amyloid precursor protein

1994 • 77 citations

Chapter 9 Amplicon-Based Herpes Simplex Virus Vectors

1994 • 75 citations

Defective Herpes Simplex Virus Vectors Expressing the Rat Brain Glucose Transporter Protect Cultured Neurons from Necrotic Insults

1995 • 61 citations

Herpes Simplex Virus Type 1 Amplicon Vectors with Glucocorticoid-Inducible Gene Expression

1995 • 60 citations

Herpes simplex virus vector system: analysis of its in vivo and in vitro cytopathic effects

1995 • 56 citations

Tetracycline repressor-regulated gene repression in recombinant human cytomegalovirus

1995 • 43 citations

Use of Herpes Simplex Virus Vectors for Protection from Necrotic Neuron Death

1995 • 10 citations

Gene Transfer to Protoplasts: Transient Gene Expression Analysis

1995 • 6 citations