Functional Redundancy of the Nuclear Factor κB Inhibitors IκBα and IκBβ

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

1997 • 988 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Rescue of the En-1 Mutant Phenotype by Replacement of En-1 with En-2

1995 • 402 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

I kappa B epsilon, a novel member of the Ikappa B family, controls RelA and cRel NF-kappa B activity

1997 • 394 citations

IκBα Deficiency Results in a Sustained NF-κB Response and Severe Widespread Dermatitis in Mice

1996 • 347 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

IκB proteins: structure, function and regulation

1997 • 330 citations

Role of Unphosphorylated, Newly Synthesized IκBβ in Persistent Activation of NF-κB

1996 • 228 citations

Critical Roles for the Bcl-3 Oncoprotein in T Cell–Mediated Immunity, Splenic Microarchitecture, and Germinal Center Reactions

1997 • 179 citations

Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2

1997 • 178 citations

Immunological defects in mice with a targeted disruption in Bcl-3.

1997 • 164 citations

Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin

1996 • 157 citations

Chronic Inflammation and Susceptibility to Bacterial Infections in Mice Lacking the Polypeptide (p)105 Precursor (NF-κB1) but Expressing p50

1998 • 147 citations

Novel IκBα Proteolytic Pathway in WEHI231 Immature B Cells

1998 • 120 citations

A New Member of the IκB Protein Family, IκBε, Inhibits RelA (p65)-Mediated NF-κB Transcription

1997 • 119 citations

A role for phosphorylation and degradation in the control of NF-κB activity

1995 • 99 citations

Genetic approaches to study Rel/NF-κB/IκB function in mice

1997 • 95 citations

Basal Phosphorylation of the PEST Domain in IκBβ Regulates Its Functional Interaction with the c-rel Proto-Oncogene Product

1996 • 91 citations

Both N- and C-Terminal Domains of RelB Are Required for Full Transactivation: Role of the N-Terminal Leucine Zipper-Like Motif

1993 • 87 citations

Isolation and fractionation of mononuclear cell populations.

1995 • 69 citations

Mechanism Responsible for T-Cell Antigen Receptor- and CD28- or Interleukin 1 (IL-1) Receptor-Initiated Regulation of IL-2 Gene Expression by NF-κB

1998 • 67 citations

Multiple Hemopoietic Defects and Lymphoid Hyperplasia in Mice Lacking the Transcriptional Activation Domain of the c-Rel Protein

1998 • 66 citations

Expression of Constitutively Active IκBβ in T Cells of Transgenic Mice: Persistent NF-κB Activity Is Required for T-Cell Immune Responses

1998 • 54 citations

Introduction: The Rel/NF-κB signal transduction pathway

1997 • 26 citations

Characterization of ES cells deficient for the p105 precursor (NF-kappa B1): role of p50 NLS.

1996 • 11 citations