Quantitative variation in obesity-related traits and insulin precursors linked to the OB gene region on human chromosome 7.

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

The investigation of linkage between a quantitative trait and a marker locus

1972 • 1,398 citations

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

1995 • 716 citations

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

1995 • 669 citations

Understanding Oral Glucose Tolerance: Comparison of Glucose or Insulin Measurements During the Oral Glucose Tolerance Test with Specific Measurements of Insulin Resistance and Insulin Secretion

1994 • 635 citations

Extensions to multivariate normal models for pedigree analysis

1982 • 517 citations

Induction of ob Gene Expression by Corticosteroids Is Accompanied by Body Weight Loss and Reduced Food Intake

1995 • 485 citations

Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue

1995 • 434 citations

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity.

1995 • 367 citations

Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins

1989 • 341 citations

Multipoint analysis of human quantitative genetic variation.

1990 • 311 citations

Do Upper-Body and Centralized Adiposity Measure Different Aspects of Regional Body-Fat Distribution? Relationship to Non-Insulin-Dependent Diabetes Mellitus, Lipids, and Lipoproteins

1987 • 306 citations

The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7.

1995 • 249 citations

Multipoint interval mapping of quantitative trait loci, using sib pairs.

1995 • 208 citations

A sib-pair approach to interval mapping of quantitative trait loci.

1994 • 200 citations

Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modeling considerations.

1993 • 196 citations

Identification of four chromosomal loci determining obesity in a multifactorial mouse model.

1995 • 182 citations

Indication for Linkage of the Human OB Gene Region With Extreme Obesity

1996 • 171 citations

Disproportionately Elevated Proinsulin in Pima Indians with Noninsulin-Dependent Diabetes Mellitus*

1990 • 171 citations

Extreme Obesity May Be Linked to Markers Flanking the Human OB Gene

1996 • 157 citations

What β-cell Defect Could Lead to Hyperproinsulinemia in NIDDM?: Some Clues From Recent Advances Made in Understanding the Proinsulin-Processing Mechanism

1994 • 152 citations

The GDBTM Human Genome Data Base Anno 1992

1992 • 136 citations

Effect of Obesity on Insulin Resistance in Normal Subjects and Patients With NIDDM

1995 • 135 citations

Heredity and Body Fat

1988 • 133 citations

Proinsulin as a Marker for the Development of NIDDM in Japanese-American Men

1995 • 130 citations

RADIOIMMUNOASSAY MAY OVERESTIMATE INSULIN IN NON‐INSULIN‐DEPENDENT DIABETICS

1990 • 114 citations

Major gene with sex‐specific effects influences fat mass in Mexican Americans

1995 • 101 citations

Segregation analysis of fat mass and other body composition measures derived from underwater weighing.

1993 • 96 citations

[13] Pro-protein convertases of subtilisin/kexin family

1994 • 87 citations

Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells.

1995 • 80 citations

Type II diabetes and its complications in Mexican Americans

1990 • 78 citations

An Exploratory Investigation of Genetic Linkage with Body Composition and Fatness Phenotypes: The Québec Family Study

1994 • 70 citations

Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro

1990 • 67 citations

Obesity, insulin resistance, and its link to non-insulin-dependent diabetes mellitus

1995 • 66 citations

The human Kell blood group gene maps to chromosome 7q33 and its expression is restricted to erythroid cells

1993 • 63 citations

Use of robust variance components models to analyse triglyceride data in families

1985 • 62 citations

Report of the First International Workshop on Human Chromosome 7 Mapping 1993

1994 • 45 citations

Human obesity does not segregate with the chromosomal regions of Prader-Willi, Bardet-Biedl, Cohen, Borjeson or Wilson-Turner syndromes.

1995 • 36 citations

Genetic analysis of a common oligogenic trait with quantitative correlates: Summary of GAW9 results

1995 • 36 citations

Genetics of obesity: an update on molecular markers.

1995 • 34 citations

Identification of Microsatellite Markers Near the Human ob Gene and Linkage Studies in NIDDM-Affected Sib Pairs

1995 • 34 citations

Association of the Prohormone Convertase 2 Gene (PCSK2) on Chromosome 20 with NIDDM in Japanese Subjects

1995 • 30 citations

Contribution of obesity to insulin resistance in noninsulin-dependent diabetes mellitus.

1995 • 25 citations

Familial Hyperproinsulinemia Associated With NIDDM: A case study

1993 • 18 citations

Strategies for the molecular genetic analysis of obesity in humans

1993 • 16 citations

Genetic models of human obesity — family studies

1993 • 10 citations

Obesity: choosing genetic approaches from a mixed menu.

1993 • 4 citations