Interactivating Feedback Loops within the Mammalian Clock: BMAL1 Is Negatively Autoregulated and Upregulated by CRY1, CRY2, and PER2

Molecular Bases for Circadian Clocks

1999 • 2,823 citations

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

1998 • 1,954 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop

1999 • 1,558 citations

Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals

2000 • 1,523 citations

Molecular Analysis of Mammalian Circadian Rhythms

2001 • 1,428 citations

An h Per2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome

2001 • 1,421 citations

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

1999 • 1,361 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

Interacting Molecular Loops in the Mammalian Circadian Clock

2000 • 1,332 citations

Nonredundant Roles of the mPer1 and mPer2 Genes in the Mammalian Circadian Clock

2001 • 873 citations

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

2000 • 850 citations

Circadian oscillation of a mammalian homologue of the Drosophila period gene

1997 • 782 citations

The mPer2 gene encodes a functional component of the mammalian circadian clock

1999 • 692 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock

1999 • 613 citations

NPAS2: An Analog of Clock Operative in the Mammalian Forebrain

2001 • 555 citations

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

1997 • 510 citations

Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature

2001 • 442 citations

Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock

1999 • 373 citations

Interlocked Feedback Loops Within the Drosophila Circadian Oscillator

1999 • 361 citations

Interconnected Feedback Loops in the Neurospora Circadian System

2000 • 352 citations

Analysis of Clock Proteins in Mouse SCN Demonstrates Phylogenetic Divergence of the Circadian Clockwork and Resetting Mechanisms

2000 • 343 citations

Multitissue Circadian Expression of Rat periodHomolog (rPer2) mRNA Is Governed by the Mammalian Circadian Clock, the Suprachiasmatic Nucleus in the Brain

1998 • 305 citations

Targeted Disruption of the mPer3 Gene: Subtle Effects on Circadian Clock Function

2000 • 297 citations

All's well that ends dead

1999 • 293 citations

GENETICS OF THE MAMMALIAN CIRCADIAN SYSTEM: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation

2000 • 293 citations

Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock

2000 • 270 citations

Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock

2001 • 242 citations

cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix–Loop–Helix/PAS Protein (BMAL1) and Identification of Alternatively Spliced Variants with Alternative Translation Initiation Site Usage

1997 • 219 citations

Molecular Components of the Circadian System in Drosophila

2001 • 210 citations

Dimerization and nuclear entry of mPER proteins in mammalian cells

2000 • 191 citations

Circadian Oscillation ofBMAL1,a Partner of a Mammalian Clock GeneClock,in Rat Suprachiasmatic Nucleus

1998 • 178 citations

dCLOCK Is Present in Limiting Amounts and Likely Mediates Daily Interactions between the dCLOCK–CYC Transcription Factor and the PER–TIM Complex

2000 • 134 citations

Expression of basic helix-loop-helix/pas genes in the mouse suprachiasmatic nucleus

1999 • 95 citations

Light and Glutamate-Induced Degradation of the Circadian Oscillating Protein BMAL1 during the Mammalian Clock Resetting

2000 • 70 citations

Characterization of Three Splice Variants and Genomic Organization of the Mouse BMAL1 Gene

1999 • 41 citations

Phase-dependent induction by light of rat Clock gene expression in the suprachiasmatic nucleus

1999 • 36 citations