GENETICS OF THE MAMMALIAN CIRCADIAN SYSTEM: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Molecular Bases for Circadian Clocks

1999 • 2,823 citations

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

1998 • 1,915 citations

Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats

2000 • 1,844 citations

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

1990 • 1,788 citations

Suprachiasmatic nucleus : the mind's clock

1991 • 1,730 citations

Mutagenesis and Mapping of a Mouse Gene, Clock , Essential for Circadian Behavior

1994 • 1,570 citations

mCRY1 and mCRY2 Are Essential Components of the Negative Limb of the Circadian Clock Feedback Loop

1999 • 1,558 citations

Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms

1995 • 1,437 citations

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

1999 • 1,361 citations

Positional Cloning of the Mouse Circadian Gene

1997 • 1,335 citations

Interacting Molecular Loops in the Mammalian Circadian Clock

2000 • 1,332 citations

SCF and Cullin/RING H2-Based Ubiquitin Ligases

1999 • 1,249 citations

A Novel Human Opsin in the Inner Retina

2000 • 1,236 citations

Cryptochromes: Blue Light Receptors for Plants and Animals

1999 • 994 citations

The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila

1998 • 952 citations

Temporal Organization: Reflections of a Darwinian Clock-Watcher

1993 • 943 citations

Melanopsin: An opsin in melanophores, brain, and eye

1998 • 927 citations

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

1999 • 894 citations

A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

1997 • 883 citations

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

1998 • 867 citations

Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript

1997 • 866 citations

CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity

1998 • 861 citations

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

2000 • 850 citations

Retinal degeneration in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase

1990 • 841 citations

Ubiquitin-mediated proteolysis: biological regulation via destruction

2000 • 839 citations

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

1998 • 820 citations

Regulation of Mammalian Circadian Behavior by Non-rod, Non-cone, Ocular Photoreceptors

1999 • 819 citations

Circadian oscillation of a mammalian homologue of the Drosophila period gene

1997 • 782 citations

A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms

1996 • 776 citations

The circadian visual system, 2005

2005 • 766 citations

Two period Homologs: Circadian Expression and Photic Regulation in the Suprachiasmatic Nuclei

1997 • 763 citations

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1998 • 761 citations

Neurophysiology of the suprachiasmatic circadian pacemaker in rodents

1989 • 737 citations

Circadian Rhythms in Cultured Mammalian Retina

1996 • 710 citations

THE DISTRIBUTION AND NATURE OF COLOUR VISION AMONG THE MAMMALS

1993 • 698 citations

A Mutation of the Circadian System in Golden Hamsters

1988 • 693 citations

The mPer2 gene encodes a functional component of the mammalian circadian clock

1999 • 692 citations

The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε

1998 • 678 citations

Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2

1999 • 668 citations

RIGUI, a Putative Mammalian Ortholog of the Drosophila period Gene

1997 • 664 citations

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

1997 • 664 citations

Rods and cones in the mouse retina. I. Structural analysis using light and electron microscopy

1979 • 655 citations

Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice

1993 • 653 citations

ZEITLUPE Encodes a Novel Clock-Associated PAS Protein from Arabidopsis

2000 • 641 citations

Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock

1999 • 613 citations

The kelch repeat superfamily of proteins: propellers of cell function

2000 • 578 citations

The retinal pigment epithelium: a versatile partner in vision

1993 • 577 citations

Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse.

1991 • 558 citations

Light-Dependent Sequestration of TIMELESS by CRYPTOCHROME

1999 • 553 citations

Molecular Genetics of Circadian Rhythms in Mammals

2000 • 541 citations

The Proteasome, a Novel Protease Regulated by Multiple Mechanisms

1999 • 540 citations

Visual excitation and recovery

1991 • 530 citations

Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms

1984 • 520 citations

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

1998 • 512 citations

Regulation of the Mammalian Pineal by Non-rod, Non-cone, Ocular Photoreceptors

1999 • 511 citations

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

1997 • 510 citations

Cellular Construction of a Circadian Clock: Period Determination in the Suprachiasmatic Nuclei

1997 • 504 citations

Circadian photoreception in the retinally degenerate mouse (rd/rd)

1991 • 494 citations

Differential effect of the rd mutation on rods and cones in the mouse retina.

1978 • 493 citations

The Suprachiasmatic Nucleus: A 25-Year Retrospective

1998 • 483 citations

FKF1, a Clock-Controlled Gene that Regulates the Transition to Flowering in Arabidopsis

2000 • 473 citations

Genetic maps: locus maps of complex genomes

1990 • 420 citations

CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP

2000 • 418 citations

Retinal receptors in rodents maximally sensitive to ultraviolet light

1991 • 416 citations

A locus control region adjacent to the human red and green visual pigment genes

1992 • 410 citations

Vitamin B ₂ -based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals

1998 • 402 citations

Drosophila CRY Is a Deep Brain Circadian Photoreceptor

2000 • 400 citations

Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds)

1989 • 399 citations

The afferent connections of the suprachiasmatic nucleus of the golden hamster with emphasis on the retinohypothalamic projection

1982 • 397 citations

Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses

1998 • 397 citations

Blue-Light Photoreceptors in Higher Plants

1999 • 394 citations

CIRCADIAN RHYTHMS: Basic Neurobiology and Clinical Applications

1997 • 393 citations

Clock controls circadian period in isolated suprachiasmatic nucleus neurons

1998 • 376 citations

Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock

1999 • 373 citations

Targeting of substrates to the 26S proteasome

1997 • 362 citations

Mammalian Circadian Autoregulatory Loop

1998 • 347 citations

The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells

1995 • 345 citations

Analysis of Clock Proteins in Mouse SCN Demonstrates Phylogenetic Divergence of the Circadian Clockwork and Resetting Mechanisms

2000 • 343 citations

Human Circadian Rhythms in Continuous Darkness: Entrainment by Social Cues

1971 • 341 citations

Pinopsin is a chicken pineal photoreceptive molecule

1994 • 341 citations

Phototransduction mechanism in retinal rods and cones. The Friedenwald Lecture.

1994 • 335 citations

The Evolution and Physiology of Human Color Vision

1999 • 327 citations

The retinal degeneration slow (rds) gene product is a photoreceptor disc membrane-associated glycoprotein

1991 • 322 citations

A Model for Circadian Rhythms in Drosophila Incorporating the Formation of a Complex between the PER and TIM Proteins

1998 • 316 citations

Phytochromes, Cryptochromes, Phototropin: Photoreceptor Interactions in Plants

2000 • 313 citations

Casein Kinase I

1998 • 294 citations

Unique topographic separation of two spectral classes of cones in the mouse retina

1992 • 294 citations

All's well that ends dead

1999 • 293 citations

Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ

2000 • 291 citations

The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction

1999 • 289 citations

Photoreceptor peripherin is the normal product of the gene responsible for retinal degeneration in the rds mouse.

1991 • 284 citations

Putative Human Blue-Light Photoreceptors hCRY1 and hCRY2 Are Flavoproteins

1996 • 283 citations

A Novel Signaling Pathway from Rod Photoreceptors to Ganglion Cells in Mammalian Retina

1998 • 277 citations

UV- and Midwave-Sensitive Cone-Driven Retinal Responses of the Mouse: A Possible Phenotype for Coexpression of Cone Photopigments

1999 • 272 citations

A Role for the Proteasome in the Light Response of the Timeless Clock Protein

1999 • 266 citations

Inhibition of Light- or Glutamate-InducedmPer1Expression Represses the Phase Shifts into the Mouse Circadian Locomotor and Suprachiasmatic Firing Rhythms

1999 • 262 citations

Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception

2000 • 260 citations

Modes of regulation of ubiquitin-mediated protein degradation

2000 • 259 citations

Similarity Among the Drosophila (6-4)Photolyase, a Human Photolyase Homolog, and the DNA Photolyase-Blue-Light Photoreceptor Family

1996 • 246 citations

Two different visual pigments in one retinal cone cell

1994 • 245 citations

Extraocular Circadian Phototransduction in Humans

1998 • 244 citations

Development and degeneration of retina in rds mutant mice: Light microscopy

1980 • 238 citations

Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and the compartment-specific response to light

1999 • 237 citations

Antiphase Circadian Expression betweenBMAL1andperiodHomologue mRNA in the Suprachiasmatic Nucleus and Peripheral Tissues of Rats

1998 • 235 citations

A light-independent oscillatory gene mPer3 in mouse SCN and OVLT

1998 • 234 citations

A new mammalian period gene predominantly expressed in the suprachiasmatic nucleus

1998 • 220 citations

cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix–Loop–Helix/PAS Protein (BMAL1) and Identification of Alternatively Spliced Variants with Alternative Translation Initiation Site Usage

1997 • 219 citations

Nonphotic entrainment of the human circadian pacemaker

1998 • 210 citations

How color visual pigments are tuned

1999 • 207 citations

A Simple Model of Circadian Rhythms Based on Dimerization and Proteolysis of PER and TIM

1999 • 192 citations

The influence of different light spectra on the suppression of pineal melatonin content in the syrian hamster

1984 • 189 citations

Crystal structure of casein kinase-1, a phosphate-directed protein kinase.

1995 • 187 citations

THE MOLECULAR CONTROL OF CIRCADIAN BEHAVIORAL RHYTHMS AND THEIR ENTRAINMENT IN DROSOPHILA

1998 • 186 citations

Circadian periods of single suprachiasmatic neurons in rats

1998 • 183 citations

Circadian rhythms in mice can be regulated by photoreceptors with cone-like characteristics

1995 • 180 citations

Circadian Oscillation ofBMAL1,a Partner of a Mammalian Clock GeneClock,in Rat Suprachiasmatic Nucleus

1998 • 178 citations

Differential Regulation of mPER1 and mTIM Proteins in the Mouse Suprachiasmatic Nuclei: New Insights into a Core Clock Mechanism

1999 • 175 citations

Molecular Analysis of Mammalian Timeless

1998 • 169 citations

Seeing blue: the discovery of cryptochrome

1996 • 166 citations

Isolation and Characterization of Human Casein Kinase I∊ (CKI), a Novel Member of the CKI Gene Family

1995 • 166 citations

Pineal Opsin: a Nonvisual Opsin Expressed in Chick Pineal

1995 • 163 citations

Absence of extraocular photoreception in diurnal and nocturnal rodents exposed to direct sunlight

1981 • 161 citations

The Mouse Clock Mutation Behaves as an Antimorph and Maps Within the W19H Deletion, Distal of Kit

1997 • 159 citations

A Mathematical Model for the Intracellular Circadian Rhythm Generator

1999 • 153 citations

Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium

1997 • 151 citations

Shedding Light on the Biological Clock

1998 • 145 citations

Rhythmic Expression of BMAL1 mRNA Is Altered in Clock Mutant Mice: Differential Regulation in the Suprachiasmatic Nucleus and Peripheral Tissues

2000 • 143 citations

Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+) mice

1996 • 140 citations

Retinal projections in mice with inherited retinal degeneration: Implications for circadian photoentrainment

1998 • 140 citations

The Physiology of Circadian Pacemakers

1978 • 139 citations

Visual and circadian responses to light in aged retinally degenerate mice

1994 • 136 citations

Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε

2000 • 135 citations

Photic regulation of Fos‐like immunoreactivity in the suprachiasmatic nucleus of the mouse

1992 • 131 citations

GFP fluorescence reports Period 1 circadian gene regulation in the mammalian biological clock

2000 • 131 citations

The Endogenous Chromophore of Retinal G Protein-coupled Receptor Opsin from the Pigment Epithelium

1999 • 128 citations

Three-dimensional Structure of Mammalian Casein Kinase I: Molecular Basis for Phosphate Recognition

1996 • 125 citations

Circadian Programs in Cyanobacteria: Adaptiveness and Mechanism

1999 • 123 citations

An opsin homologue in the retina and pigment epithelium.

1993 • 119 citations

Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis

1994 • 114 citations

Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: mapping elements of the PER protein involved in circadian cycling.

1997 • 114 citations

Developmental Expression Pattern of Phototransduction Components in Mammalian Pineal Implies a Light-Sensing Function

1997 • 111 citations

Evidence for a nonretinal pathway of light to the pineal gland of newborn rats.

1966 • 106 citations

INVERTEBRATE VISUAL PIGMENTS

1995 • 104 citations

The Third Eye

1973 • 104 citations

Temporal and Spatial Expression Patterns of Transgenes Containing Increasing Amounts of theDrosophilaClock Geneperiodand alacZReporter: Mapping Elements of the PER Protein Involved in Circadian Cycling

1997 • 103 citations

Modeling the molecular regulatory mechanism of circadian rhythms in Drosophila

2000 • 100 citations

No Evidence for Extraocular Photoreceptors in the Circadian System of the Syrian Hamster

1999 • 100 citations

Representational difference analysis: finding the differences between genomes

1995 • 97 citations

Resetting of the circadian clock by a conditioned stimulus

1996 • 94 citations

Circadian clocks in the mammalian brain

2000 • 91 citations

Multiple regulatory elements result in regional specificity in circadian rhythms of neuropeptide expression in mouse SCN

1999 • 89 citations

A Human Opsin-Related Gene That Encodes a Retinaldehyde-Binding Protein

1994 • 89 citations

Morphological characteristics of retinal ganglion cells projecting to the suprachiasmatic nucleus: a horseradish peroxidase study

1980 • 88 citations

Ubiquitin-Dependent Signaling: The Role of Ubiquitination in the Response of Cells to Their Environment.

1999 • 83 citations

Extraocular Light Exposure Does Not Suppress Plasma Melatonin in Humans

1998 • 83 citations

Cytoplasmic Retinal Localization of an Evolutionary Homolog of the Visual Pigments

1994 • 82 citations

Characterization of photolyase/blue-light receptor homologs in mouse and human cells

1998 • 82 citations

Blue and Ultraviolet Light-Absorbing Opsin from the Retinal Pigment Epithelium

1996 • 81 citations

Regional variations in the relative sensitivity to UV light in the mouse retina

1995 • 80 citations

Morphological and Physiological Consequences of the Selective Elimination of Rod Photoreceptors in Transgenic Mice

1996 • 75 citations

Neither Functional Rod Photoreceptors nor Rod or Cone Outer Segments Are Required for the Photic Inhibition of Pineal Melatonin*

1999 • 73 citations

Cloning, Tissue Expression, and Mapping of a Human Photolyase Homolog with Similarity to Plant Blue-Light Receptors

1996 • 73 citations

Effect of Light Irradiance and Wavelength on the Syrian Hamster Reproductive System*

1986 • 72 citations

Sensitivity to ultraviolet light in the gerbil (Meriones unguiculatus): Characteristics and mechanisms

1994 • 70 citations

A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1

1999 • 69 citations

Circadian Cycling of a PERIOD-β-galactosidase Fusion Protein in Drosophila: Evidence for Cyclical Degradation

1997 • 68 citations

Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1¹

1998 • 68 citations

Origins of uncrossed retinofugal projections in normal and hypopigmented mice

1990 • 67 citations

Transgenic ablation of rod photoreceptors alters the circadian phenotype of mice

1999 • 65 citations

A Drosophila circadian clock.

1996 • 65 citations

Ultraviolet regulation of neuroendocrine and circadian physiology in rodents

1994 • 63 citations

Seeing the world in red and blue: insight into plant vision and photoreceptors

1999 • 63 citations

Circadian rhythm and light responsiveness of BMAL1 expression, a partner of mammalian clock gene Clock, in the suprachiasmatic nucleus of rats

1998 • 61 citations

Cone receptor variations and their functional consequences in two species of hamster

1999 • 57 citations

The Suppression of Nocturnal Pineal Melatonin in the Syrian Hamster: Dose-Response Curves at 500 and 360 nm*

1987 • 56 citations

Light perception in higher plants

1999 • 53 citations

The circadian clocks of plants and cyanobacteria

1999 • 53 citations

Oscillation and Light Induction oftimelessmRNA in the Mammalian Circadian Clock

1999 • 52 citations

Near-Ultraviolet Radiation Suppresses Pineal Melatonin Content*

1986 • 51 citations

Photoentrainment in Mammals: A Role for Cryptochrome?

1999 • 50 citations

Photopigments and photoentrainment in the Syrian golden hamster

1997 • 46 citations

Cloning and nucleotide sequence of cDNA for retinochrome, retinal photoisomerase from the squid retina

1990 • 45 citations

Scotopic spectral sensitivity of phakic and aphakic observers extending into the near ultraviolet

1992 • 42 citations

Characterization of a human homolog of (6-4)photolyase

1997 • 41 citations

Nocturnal melatonin secretion is not suppressed by light exposure behind the knee in humans

1999 • 41 citations

Photosensitivity of Chromatophores

1983 • 39 citations

Molecular Neurogenetics of Biological Rhythms

1998 • 39 citations

Light-induced c-fos mRNA expression in the suprachiasmatic nucleus and the retina of C3H/HeN mice

1996 • 38 citations

Ultraviolet light entrains rodent suprachiasmatic nucleus pacemaker

1995 • 37 citations

Neurobiological aspects of extraretinal photoreceptive systems: structure and function

1982 • 36 citations

Phase-dependent induction by light of rat Clock gene expression in the suprachiasmatic nucleus

1999 • 36 citations

Functional absence of extraocular photoreception in hamster circadian rhythm entrainment

1999 • 35 citations

Crystallographic studies of casein kinase I δ: toward a structural understanding of auto-inhibition

1998 • 32 citations

No evidence for extraocular light induced phase shifting of human melatonin, cortisol and thyrotropin rhythms

2000 • 31 citations

The Scientific Attitude.Frederick Grinnell

1993 • 31 citations

The ins and outs of circadian regulated gene expression

1999 • 29 citations

Photomechanical coupling in the vertebrate sphincter pupillae.

1989 • 28 citations

No Melatonin Suppression by Illumination of Popliteal Fossae or Eyelids

2000 • 27 citations

Fos expression in the retina of rd/rd mice during the light/dark cycle

1997 • 19 citations

Linkage map of Syrian hamster with restriction landmark genomic scanning

1997 • 14 citations

Effects of different light wavelengths at equal irradiance on testis weight, protein content, and K-paranitrophenylphosphatase activity in the skin hamster

1987 • 5 citations

[Contractile activity of the gastrointestinal system and spontaneous somatomotor excitation in the early postnatal ontogenesis of rats].

1997 • 4 citations

cDNA cloning and chromosome mapping of the mouse casein kinase I epsilon gene <i>(Csnk1e)</i>

1999 • 3 citations