Identification of a Human CD8+T Lymphocyte Neo-epitope Created by arasCodon 12 Mutation Which Is Restricted by the HLA-A2 Allele

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

ras GENES

1987 • 3,818 citations

Current protocols in molecular biology

1988 • 2,473 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

HISTOCOMPATIBILITY TESTING, 1972

1974 • 1,267 citations

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

1994 • 1,108 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1994 • 934 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 • 656 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

1996 • 566 citations

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 • 553 citations

HLA-A2.1-Associated Peptides from a Mutant Cell Line: A Second Pathway of Antigen Presentation

1992 • 522 citations

Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

1995 • 506 citations

Enhanced Generation of Specific Tumor-Reactive CTL In Vitro by Selected Melan-A/MART-1 Immunodominant Peptide Analogues

1998 • 487 citations

Breast and ovarian cancer-specific cytotoxic T lymphocytes recognize the same HER2/neu-derived peptide.

1995 • 446 citations

Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid.

1986 • 437 citations

Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors

1997 • 432 citations

High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.

1989 • 414 citations

Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides.

1995 • 387 citations

Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.

1991 • 336 citations

Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1.

1995 • 296 citations

In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild‐type p53

1993 • 267 citations

Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs

1996 • 263 citations

Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype.

1995 • 213 citations

Antitumor Activity and Immune Responses Induced by a Recombinant Carcinoembryonic Antigen-Vaccinia Virus Vaccine

1992 • 212 citations

Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.

1991 • 208 citations

Rapid and sensitive nonradioactive detection of mutant K-ras genes via 'enriched' PCR amplification.

1991 • 184 citations

Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12VAL) peptide vaccination of a patient, recognize 12VAL-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation

1997 • 163 citations

Interleukin-12. Biologic activity, therapeutic utility, and role in disease.

1995 • 163 citations

Endogenous peptides of a soluble major histocompatibility complex class I molecule, H-2Lds: sequence motif, quantitative binding, and molecular modeling of the complex.

1992 • 146 citations

H-2Kd-restricted antigenic peptides share a simple binding motif.

1991 • 145 citations

c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung

1995 • 127 citations

MUTATIONS OF RAS GENES IN HUMAN TUMORS (REVIEW)

1995 • 127 citations

Differential Anti-MART-1/MelanA CTL Activity in Peripheral Blood of HLA-A2 Melanoma Patients in Comparison to Healthy Donors

1996 • 127 citations

Detection of K-ras Mutation in Colonic Effluent Samples From Patients Without Evidence of Colorectal Carcinoma

1994 • 102 citations

H-2Dd exploits a four residue peptide binding motif.

1993 • 98 citations

Generation of Stable CD4+and CD8+T Cell Lines from Patients Immunized withrasOncogene-Derived Peptides Reflecting Codon 12 Mutations

1997 • 88 citations

Mutant ras epitopes as targets for cancer vaccines.

1996 • 87 citations

p21‐ras‐peptide‐specific T‐cell responses in a patient with colorectal cancer. CD4⁺ and CD8⁺ T cells recognize a peptide corresponding to a common mutation (13Gly → Asp)

1994 • 85 citations

Induction and characterization of cytotoxic T‐lymphocytes recognizing a mutated p21ras peptide presented by HLA‐A*0201

1995 • 84 citations

Intraperitoneal administration of interferon-gamma to carcinoma patients enhances expression of tumor-associated glycoprotein-72 and carcinoembryonic antigen on malignant ascites cells.

1992 • 62 citations

T-cell responses against products of oncogenes: Generation and characterization of human T-cell clones specific for p21 ras-derived synthetic peptides

1992 • 61 citations

Overlapping epitopes encompassing a point mutation (12 Gly → Arg) in p21 ras can be recognized by HLA‐DR, ‐DP and ‐DQ restricted T cells

1993 • 60 citations

CD8+T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (GLY13?ASP), are cytotoxic towards a carcinoma cell line harbouring the same mutation

1995 • 60 citations

Identification of overlapping epitopes in mutant ras oncogene peptides that activate CD4⁺ and CD8⁺ T cell responses

1996 • 59 citations

K-ras gene mutations in adenomas and carcinomas of the colon

1992 • 55 citations

Synergistic Effects of IL-6 and IFN-γ on Carcinoembryonic Antigen (CEA) and HLA Expression by Human Colorectal Carcinoma Cells: Role for Endogenous IFN-β

1995 • 53 citations

A unified theory for the development of cancer

1986 • 49 citations

Characterization of HLA-A 0201-restricted cytotoxic T cell epitopes in conserved regions of the HIV type 1 gp160 protein.

1995 • 45 citations

Peptide‐specific activation of cytolytic CD4⁺ T lymphocytes against tumor cells bearing mutated epitopes of K‐ras p21

1995 • 42 citations

Systemic administration of recombinant interferon alfa in carcinoma patients upregulates the expression of the carcinoma-associated antigens tumor-associated glycoprotein-72 and carcinoembryonic antigen.

1996 • 38 citations

A K‐ras 13GLY → ASP mutation is recognized by HLA‐DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?

1994 • 38 citations

Development of a Murine Mutant Ras CD8+ CTL Peptide Epitope Variant That Possesses Enhanced MHC Class I Binding and Immunogenic Properties

1998 • 36 citations

Characterisation of immune responses in pancreatic carcinoma patients after mutant p21 ras peptide vaccination

1996 • 30 citations

Cytotoxic T-lymphocyte responses against mutated p21 ras peptides: An analysis of specific T-cell-receptor gene usage

1996 • 21 citations

Improved experimental radioimmunotherapy of colon xenografts by combining131I-CC49 and Interferon-γ

1994 • 16 citations

Growth inhibition of a colonic adenocarcinoma cell line (HT29) by T cells specific for mutant p21 ras

1994 • 16 citations

Recognition by HLA-A2-restricted cytotoxic T lymphocytes of endogenously generated and exogenously provided synthetic peptide analogues of the influenza a virus matrix protein

1993 • 14 citations

Activated Val-12 ras p21 in cell culture fluids and mouse plasma.

1991 • 12 citations

Novel approaches to tumor detection and therapy using a combination of monoclonal antibody and cytokine.

1996 • 8 citations