CD8+T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (GLY13?ASP), are cytotoxic towards a carcinoma cell line harbouring the same mutation

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

1994 • 421 citations

HLA class I and II typing using cells positively selected from blood by immunomagnetic isolation ‐ a fast and reliable technique

1986 • 282 citations

Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.

1989 • 275 citations

Lysis of human melanoma cells by autologous cytolytic T cell clones. Identification of human histocompatibility leukocyte antigen A2 as a restriction element for three different antigens.

1989 • 223 citations

Human T lymphocytes recognize a peptide of single point-mutated, oncogenic ras proteins.

1991 • 208 citations

Proteasomes are regulated by interferon gamma: implications for antigen processing.

1992 • 177 citations

Expression of the adhesion molecule ICAM-1 and major histocompatibility complex class I antigens on human tumor cells is required for their interaction with autologous lymphocytes in vitro

1990 • 139 citations

K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location

1994 • 137 citations

Isolation of pure functionally active CD8+ T cells positive selection with monoclonal antibodies directly conjugated to monosized magnetic microspheres

1986 • 137 citations

Distribution of HLA class II alleles among Norwegian caucasians

1990 • 119 citations

p21‐ras‐peptide‐specific T‐cell responses in a patient with colorectal cancer. CD4⁺ and CD8⁺ T cells recognize a peptide corresponding to a common mutation (13Gly → Asp)

1994 • 85 citations

Identification of two cytotoxic T lymphocyte-recognized epitopes in the Ras protein.

1993 • 83 citations

Memory T cells of a patient with follicular thyroid carcinoma recognize peptides derived from mutated p21 ras (Gin → Leu61)

1992 • 67 citations

Cytotoxic T-Cell Response and In Vivo Protection Against Tumor Cells Harboring Activated ras Proto-oncogenes

1993 • 66 citations

Serum proteases alter the antigenicity of peptides presented by class I major histocompatibility complex molecules.

1992 • 64 citations

T-cell responses against products of oncogenes: Generation and characterization of human T-cell clones specific for p21 ras-derived synthetic peptides

1992 • 61 citations

Overlapping epitopes encompassing a point mutation (12 Gly → Arg) in p21 ras can be recognized by HLA‐DR, ‐DP and ‐DQ restricted T cells

1993 • 60 citations

T cell clones specific for p21 ras‐derived peptides: Characterization of their fine specificity and HLA restriction

1993 • 56 citations

Lysis of human pancreatic adenocarcinoma cells by autologous hla‐class I‐restricted cytolytic T‐lymphocyte (CTL) clones

1993 • 47 citations

A K‐ras 13GLY → ASP mutation is recognized by HLA‐DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?

1994 • 38 citations