Functional characterization of substance P receptors on cultured human spinal cord astrocytes: Synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1982 • 2,148 citations

Interleukin-6: An Overview

1990 • 1,910 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

Prostaglandin synthase 2

1996 • 1,212 citations

Neurotransmitter functions of mammalian tachykinins.

1993 • 1,101 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta.

1993 • 789 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

Multiple extracellular signals are required for long-term oligodendrocyte survival

1993 • 707 citations

Tachykinin receptors and tachykinin receptor antagonists

1993 • 649 citations

Chemokines, leukocyte trafficking, and inflammation

1994 • 636 citations

A new view of prostaglandin E regulation of the immune response

1991 • 535 citations

A potent and selective non-peptide antagonist of the neurokinin a (NK2) receptor

1992 • 441 citations

HEMOPOIETIC CELL GROWTH FACTORS AND THEIR RECEPTORS

1989 • 432 citations

Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6

1988 • 402 citations

Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha.

1992 • 402 citations

Highly selective agonists for substance P receptor subtypes.

1986 • 316 citations

Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

1988 • 295 citations

Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes. Two distinct pathways of the gene expression

1991 • 253 citations

Cholinergic differentiation factor (CDF/LIF) promotes survival of isolated rat embryonic motoneurons in vitro

1992 • 246 citations

Elevated central nervous system prostaglandins in human immunodeficiency virus—associated dementia

1994 • 226 citations

Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha.

1994 • 193 citations

Interleukin‐1β Induces Prostaglandin G/H Synthase‐2 (Cyclooxygenase‐2) in Primary Murine Astrocyte Cultures

1996 • 190 citations

Induction of Prostanoid Biosynthesis by Bacterial Lipopolysaccharide and Isoproterenol in Rat Microglial Cultures

1995 • 181 citations

INTERLEUKIN-1BETAINCREASES PROSTAGLANDIN E₂IN RAT ASTROCYTE CULTURES: MODULATORY EFFECT OF NEUROPEPTIDES

1989 • 173 citations

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels

1992 • 160 citations

Pharmacological profile of a high affinity dipeptide NK₁ receptor antagonist, FK888

1992 • 146 citations

Inducible nitric oxide synthase expression in activated rat microglial cultures is downregulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors

1997 • 142 citations

Prostaglandin E2 protects cultured cortical neurons against N-methyl-d-aspartate receptor-mediated glutamate cytotoxicity

1994 • 137 citations

Tumor necrosis factor α and transforming growth factor β upregulate astrocyte expression of monocyte chemoattractant protein-1

1995 • 129 citations

Astrocyte cultures from human embryonic brain: Characterization and modulation of surface molecules by inflammatory cytokines

1992 • 122 citations

Substance P receptor binding sites are expressed by glia in vivo after neuronal injury.

1989 • 120 citations

Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis.

1994 • 116 citations

Substance P‐Induced Release of Prostaglandins from Astrocytes: Regional Specialisation and Correlation with Phosphoinositol Metabolism

1991 • 104 citations

Beta 2-adrenergic receptors are expressed by glia in vivo in the normal and injured central nervous system in the rat, rabbit, and human

1995 • 102 citations

Substance P stimulates IL-1 production by astrocytes via intracellular calcium

1992 • 101 citations

Tachykinin Receptors of the NK1 Type (Substance P) Coupled Positively to Phospholipase C on Cortical Astrocytes from the Newborn Mouse in Primary Culture

1989 • 100 citations

Substance P and astrocytes: stimulation of the cyclooxygenase pathway of arachidonic acid metabolism

1988 • 98 citations

Interleukin-1 binding sites on astrocytes

1993 • 96 citations

A phosphoinositide-linked peptide response in astrocytes: Evidence for regional heterogeneity

1988 • 94 citations

Interleukin-6 secretion from human astrocytoma cells induced by substance P

1994 • 78 citations

Recombinant interleukin-1β stimulates eicosanoid production in rat primary culture astrocytes

1989 • 74 citations

Expression of beta‐adrenergic receptors by astrocytes isolated from adult rat cortex

1989 • 73 citations

Regulation of leukemia inhibitory factor synthesis in cultured human astrocytes.

1994 • 71 citations

Interleukin‐1β Uses Common and Distinct Signaling Pathways for Induction of the Interleukin‐6 and Tumor Necrosis Factor α Genes in the Human Astrocytoma Cell Line U373

1996 • 68 citations

Downregulation of in vitro neurotoxicity of brain macrophages by prostaglandin E₂ and a β‐adrenergic agonist

1994 • 64 citations

Substance P immunoreactive astrocytes are present in multiple sclerosis plaques

1989 • 60 citations

Functional characterization of neurokinin‐1 receptors on human U373MG astrocytoma cells

1992 • 50 citations

Potential role of prostaglandins and leukotrienes in multiple sclerosis and experimental allergic encephalomyelitis

1992 • 48 citations

Prostacyclin (PGI2) protects rat cortical neurons in culture against hypoxia/reoxygenation and glutamate-induced injury

1993 • 45 citations

Synergistic Regulation of Cytosolic Ca²⁺Concentration in Mouse Astrocytes by NK1 Tachykinin and Adenosine Agonists

1991 • 38 citations

Substance P Receptors on O‐2A Progenitor Cells and Type‐2 Astrocytes In Vitro

1993 • 36 citations

Expression of type I interleukin-1 receptor mRNA and its regulation in cultured astrocytes

1995 • 33 citations

Changes in 3H-substance P receptor binding in the rat brain after kainic acid lesion of the corpus striatum

1986 • 31 citations

Marked Regional Heterogeniety of ¹²⁵I‐Bolton Hunter Substance P Binding and Substance P‐Induced Activation of Phospholipase C in Astrocyte Cultures from the Embryonic or Newborn Rat

1990 • 30 citations

Preprotachykinin-A and substance P receptor (NK1) gene expression in rat astrocytes in vitro

1994 • 30 citations

Neuronal Factors Modulating Immunity

1994 • 29 citations

NK-1 receptors are the only class of tachykinin receptors found on mouse cortical astrocytes

1991 • 28 citations

Interleukin-6 production by U373 MG, a human astrocytoma cell line: different pathways involved in substance P and lipopolysaccharide activation

1995 • 26 citations

Tachykinin‐Stimulated Inositol Phospholipid Hydrolysis and Taurine Release from Human Astrocytoma Cells

1992 • 23 citations

Comparison of tachykinin NK1 receptors in human IM9 and U373 MG cells, using antagonist (FK888, (±)-CP-96,345, and RP 67580) binding

1994 • 18 citations

Role of Inositol Phosphates in the Actions of Substance P on NK₁ Receptors in Exocrine Gl and Cells

1991 • 16 citations

Substance P-immunoreactive astrocytes in gracile sensory nervous tract of spinal cord in gracile axonal dystrophy mutant mouse

1993 • 8 citations