Role of Inositol Phosphates in the Actions of Substance P on NK₁ Receptors in Exocrine Gl and Cells

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

Inositol phospholipids and cell surface receptor function

1975 • 2,458 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

A novel receptor-operated Ca2+-permeable channel activated by ATP in smooth muscle

1987 • 786 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Isolation of a Sialogogic Peptide from Bovine Hypothalamic Tissue and Its Characterization as Substance P

1970 • 689 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

1989 • 583 citations

myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.

1984 • 567 citations

Synergism of inositol trisphosphate and tetrakisphosphate in activating Ca2+-dependent K+ channels

1987 • 529 citations

Regulation of calcium influx by second messengers in rat mast cells

1988 • 506 citations

Regulation of Adenylyl Cyclase-Coupled beta-Adrenergic Receptors

1988 • 389 citations

Inositol phosphates: synthesis and degradation.

1988 • 359 citations

Phosphoinositides and receptor mechanisms

1987 • 320 citations

Exchange characteristics of the noradrenaline‐sensitive calcium store in vascular smooth muscle cells or rabbit ear artery.

1981 • 291 citations

Role of Ca2+-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2+-ATPase inhibitor, thapsigargin

1990 • 276 citations

Regulation of cytosolic free calcium in fura-2-loaded rat parotid acinar cells.

1987 • 245 citations

Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C.

1987 • 203 citations

Muscarinic, alpha‐adrenergic and peptide receptors regulate the same calcium influx sites in the parotid gland.

1977 • 197 citations

Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.

1986 • 194 citations

Long-term phorbol ester treatment down-regulates protein kinase C and sensitizes the phosphoinositide signaling pathway to hormone and growth factor stimulation. Evidence for a role of protein kinase C in agonist-induced desensitization.

1988 • 186 citations

Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices

1984 • 180 citations

Inositol 1,3,4,5-tetrakisphosphate is essential for sustained activation of the Ca2+-dependent K+ current in single internally perfused mouse lacrimal acinar cells

1989 • 163 citations

Inositol(1,3,4,5)tetrakisphosphate-induced activation of sea urchin eggs requires the presence of inositol trisphosphate

1987 • 163 citations

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

1986 • 154 citations

Influence of inositol 1,4,5-trisphosphate and guanine nucleotides on intracellular calcium release within the N1E-115 neuronal cell line.

1986 • 146 citations

Pathway for inositol 1,3,4-trisphosphate and 1,4-bisphosphate metabolism.

1987 • 115 citations

The effects of substance P and carbachol on inositol tris- and tetrakisphosphate formation and cytosolic free calcium in rat parotid acinar cells. A correlation between inositol phosphate levels and calcium entry.

1987 • 105 citations

Formation and metabolism of [3H]inositol phosphates in AR42J pancreatoma cells. Substance P-induced Ca2+ mobilization in the apparent absence of inositol 1,4,5-trisphosphate 3-kinase activity.

1988 • 104 citations

Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.

1986 • 101 citations

A guanine nucleotide-dependent regulatory protein couples substance P receptors to phospholipase C in rat parotid gland

1986 • 95 citations

Origins of myo-inositol tetrakisphosphates in agonist-stimulated rat pancreatoma cells. Stimulation by bombesin of myo-inositol 1,3,4,5,6-pentakisphosphate breakdown to myo-inositol 3,4,5,6-tetrakisphosphate.

1990 • 95 citations

Inositol 1,3,4,5‐tetrakisphosphate and inositol 1,4,5‐trisphosphate act by different mechanisms when controlling C²⁺ in mouse lacrimal acinar cells

1989 • 89 citations

The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate.

1987 • 82 citations

Effect of substance P and eledoisin on K+ efflux, amylase release and cyclic nucleotide levels in slices of rat parotid gland

1976 • 81 citations

Control of calcium channels by membrane receptors in the rat parotid gland.

1978 • 69 citations

Dependence of intracellular effects of GTPγS and inositoltrisphosphate on cell membrane potential and on external Ca ions

1987 • 63 citations

Functional substance P receptors on a rat pancreatic acinar cell line

1985 • 58 citations

Current topics in cellular regulation

1985 • 56 citations

Phorbol ester inhibits bradykinin-stimulated inositol trisphosphate formation and calcium mobilization in neuroblastoma x glioma hybrid NG108-15 cells.

1987 • 51 citations

Dual Mechanisms of Platelet Hormone Receptor Desensitization

1989 • 37 citations

Phorbol ester inhibits cholecystokinin octapeptide-induced amylase secretion and calcium mobilization, but is without effect on secretagogue-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in rabbit pancreatic acini

1987 • 36 citations

Inositol 1,4,5-trisphosphate-induced calcium release from platelet plasma membrane vesicles

1988 • 36 citations

Calcium mobilization in permeabilized fibroblasts: Effects of inositol trisphosphate, orthovanadate, mitogens, phorbol ester, and guanosine triphosphate

1987 • 29 citations

Nature and precursors of juvenile hormone-induced excessive cuticular melanisation in German cockroach

1977 • 15 citations

Stimulus-secretion coupling in exocrine glands: The role of inositol-l, 4, 5-trisphosphate calcium and cAMP

1985 • 13 citations