Interleukin-6 secretion from human astrocytoma cells induced by substance P

The biology of interleukin-6

1989 • 1,964 citations

An unidentified depressor substance in certain tissue extracts

1931 • 1,565 citations

The biology of interleukin-6

1989 • 1,459 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes

1988 • 929 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

LONG TERM CULTURE OF NORMAL AND NEOPLASTIC HUMAN GLIA

1968 • 706 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Stimulation of connective tissue cell growth by substance P and substance K

1985 • 681 citations

Differential effects of vasoactive intestinal peptide, substance P, and somatostatin on immunoglobulin synthesis and proliferations by lymphocytes from Peyer's patches, mesenteric lymph nodes, and spleen.

1986 • 579 citations

Tachykinins

1988 • 542 citations

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

1991 • 484 citations

Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response

1990 • 483 citations

Specific stimulation of human T lymphocytes by substance P.

1983 • 461 citations

Substance P Activation of Rheumatoid Synoviocytes: Neural Pathway in Pathogenesis of Arthritis

1987 • 450 citations

New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization

1988 • 360 citations

Tachykinin receptor types: Classification and membrane signalling mechanisms

1991 • 342 citations

Induction and regulation of interleukin-6 gene expression in rat astrocytes

1990 • 314 citations

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated ‘acute phase response’ in the brain?

1991 • 267 citations

Substance P: binding properties and studies on cellular responses in guinea pig macrophages.

1986 • 262 citations

Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats

1989 • 252 citations

Selective agonists for substance P and neurokinin receptors

1987 • 239 citations

Substance P and Neurokinins

1987 • 197 citations

Receptors for Substance P and Related Neurokinins

1989 • 187 citations

Interleukin-6 production by astrocytes: Induction by the neurotransmitter norepinephrine

1993 • 181 citations

IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line.

1991 • 166 citations

The Neuropeptide Substance P Stimulates Production of Interleukin 1 in Human Blood Monocytes: Activated Cells are Preferentially Influenced by the Neuropeptide

1990 • 152 citations

Neuropeptide Regulation of Interleukin-6 Production from the Pituitary: Stimulation by Pituitary Adenylate Cyclase Activating Polypeptide and Calcitonin Gene-Related Peptide*

1991 • 151 citations

Substance P enhances IL-2 expression in activated human T cells.

1992 • 145 citations

Effects of Substance P and Substance K on the Growth of Cultured Keratinocytes

1988 • 136 citations

In vivo immunomodulation by the neuropeptide substance P.

1988 • 136 citations

Substance P, neurokinin A, and neurokinin B induce generation of IL-1-like activity in P388D1 cells. Possible relevance to arthritic disease.

1988 • 126 citations

Substance P receptor binding sites are expressed by glia in vivo after neuronal injury.

1989 • 120 citations

NK₁‐receptors mediate the proliferative response of human fibroblasts to tachykinins

1990 • 111 citations

Modulation of T lymphocyte function by neuropeptides. Evidence for their role as local immunoregulatory elements.

1993 • 111 citations

Structure-activity studies of neurokinin A

1989 • 106 citations

Substance P‐Induced Release of Prostaglandins from Astrocytes: Regional Specialisation and Correlation with Phosphoinositol Metabolism

1991 • 104 citations

Substance P stimulates IL-1 production by astrocytes via intracellular calcium

1992 • 101 citations

Tachykinin Receptors of the NK1 Type (Substance P) Coupled Positively to Phospholipase C on Cortical Astrocytes from the Newborn Mouse in Primary Culture

1989 • 100 citations

Substance P and astrocytes: stimulation of the cyclooxygenase pathway of arachidonic acid metabolism

1988 • 98 citations

Substance P receptors in primary cultures of cortical astrocytes from the mouse.

1986 • 97 citations

Production of interleukin-1 by microglia in response to substance P: role for a non-classical NK-1 receptor

1993 • 90 citations

Substance P acts directly upon cloned B lymphoma cells to enhance IgA and IgM production.

1991 • 89 citations

Stimulation of IL-2 production in murine lymphocytes by substance P and related tachykinins.

1993 • 87 citations

Differential expression of interleukin-1 and tumor necrosis factor in murine septic shock models.

1989 • 87 citations

Induction of interleukin‐1 receptors on chondrocytes by fibroblast growth factor: A possible mechanism for modulation of interleukin‐1 activity

1989 • 74 citations

Substance P enhances interferon-γ production by human peripheral blood mononuclear cells

1987 • 74 citations

Substance P modulates antigen-induced, IFN-gamma production in murine Schistosomiasis mansoni.

1993 • 69 citations

IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line: Positive and negative modulation by chorela toxin and cAMP

1990 • 62 citations

Substance P immunoreactive astrocytes are present in multiple sclerosis plaques

1989 • 60 citations

Characterization of a Human NK₁ Tachykinin Receptor in the Astrocytoma Cell Line U 373 MG

1993 • 58 citations

Dexamethasone regulation of the expression of cytokine mRNAs induced by interleukin‐1 in the astrocytoma cell line U373MG

1989 • 57 citations

Functional substance P receptors on a human astrocytoma cell line (U-373 MG)

1989 • 51 citations

Potentiation of IL-1-induced BALB/3T3 fibroblast proliferation by neuropeptides.

1988 • 51 citations

Substance P and neurodegenerative disorders. A speculative review

1991 • 49 citations

[23] Synthesis of bradykinin analogs

1988 • 49 citations

Characterization of Receptors for Substance P in Human Astrocytoma Cells: Radioligand Binding and Inositol Phosphate Formation

1992 • 42 citations

Stimulation of Human B Lymphocyte Differentiation by the Neuropeptides Substance P and Neurokinin A

1989 • 42 citations

Chapter 38: The involvement of astrocytes and an acute phase response in the amyloid deposition of Alzheimer's disease

1992 • 39 citations

Neuropeptide Modulation of Interferon Gamma Production

1990 • 14 citations

Quinuclidine chemistry. 4. Diuretic properties of cis-3-amino-2-benzhydrylquinuclidine

1975 • 14 citations