Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis.

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group.

1993 • 1,227 citations

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

1994 • 799 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.

1989 • 578 citations

IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

1992 • 540 citations

Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response

1990 • 483 citations

A population‐based study of multiple sclerosis in twins: Update

1993 • 420 citations

A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in Vitro

1986 • 391 citations

HIV‐1, macrophages, glial cells, and cytokines in AIDS nervous system disease

1991 • 359 citations

Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies.

1980 • 341 citations

Induction and regulation of interleukin-6 gene expression in rat astrocytes

1990 • 314 citations

Primary demyelination in Theiler's virus infection. An ultrastructural study.

1975 • 273 citations

Cytokine accumulations in CSF of multiple sclerosis patients

1990 • 270 citations

Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis

1983 • 243 citations

Heterogeneity of poly(I).poly(C)-induced human fibroblast interferon mRNA species

1980 • 199 citations

Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain

1992 • 195 citations

In vitro production of IL-6, IL-1 beta, and tumor necrosis factor-alpha by human embryonic microglial and neural cells.

1993 • 195 citations

Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region.

1986 • 187 citations

Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV)

1990 • 179 citations

Experimental models of virus‐induced demyelination of the central nervous system

1982 • 174 citations

Identification of Theiler's virus infected cells in the central nervous system of the mouse during demyelinating disease

1987 • 164 citations

The Effect of L3T4 T Cell Depletion on the Pathogenesis of Theiler's Murine Encephalomyelitis Virus Infection in CBA Mice

1987 • 155 citations

Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis

1990 • 149 citations

Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus.

1987 • 141 citations

Theiler's virus infection of beta 2-microglobulin-deficient mice

1993 • 141 citations

Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection.

1982 • 139 citations

Demyelinative myelopathy in mice induced by the DA virus

1976 • 139 citations

Interleukin-6 is elevated in plasma in multiple sclerosis

1991 • 129 citations

Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody.

1988 • 128 citations

Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: Synergism with IL-1β and TNFα

1993 • 124 citations

Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin.

1993 • 116 citations

Class I‐deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination

1993 • 112 citations

Partial suppression of Theiler's virus‐induced demyelination in vivo by administration of monoclonal antibodies to immune‐response gene products (Ia antigens)

1986 • 104 citations

Cytotoxic T cells isolated from the central nervous systems of mice infected with Theiler's virus

1991 • 101 citations

Elevated levels of interleukin-6 in serum and cerebrospinal fluid of HTLV-I-associated myelopathy/tropical spastic paraparesis

1990 • 91 citations

Simultaneous production of interleukin 6, interferon‐β and colony‐stimulating activity by fibroblasts after viral and bacterial infection

1989 • 90 citations

Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection

1986 • 89 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. II. Survey of host immune responses and central nervous system virus titers in inbred mouse strains

1987 • 89 citations

The effect of short-term and chronic immunosuppression on Theiler's virus demyelination

1982 • 88 citations

Transforming growth factors β1 and β2: cytokines with identical immunosuppressive effects and a potential role in the regulation of autoimmune T cell function

1989 • 84 citations

Characterization of the inflammatory response in the central nervous system of mice susceptible or resistant to demyelination by Theiler's virus.

1989 • 81 citations

Immunosuppression promotes CNS remyelination in chronic virus‐induced demyelinating disease

1992 • 75 citations

Long-term treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β2

1993 • 74 citations

Monoclonal anti-I-A antibody reverses chronic paralysis and demyelination in Theiler's virus-infected mice: critical importance of timing of treatment

1987 • 70 citations

Interleukin 6 inhibits delayed‐type hypersensitivity and the development of adjuvant arthritis

1991 • 68 citations

Central Nervous System Immunity in Mice Infected with Theiler's Virus. I. Local Neutralizing Antibody Response

1978 • 64 citations

Cerebrospinal fluid interleukin-6 activity in HIV infection and inflammatory and noninflammatory diseases of the nervous system

1990 • 64 citations

Contrasting effects of immunosuppression on Theiler's virus infection in mice

1977 • 64 citations

A SURVEY OF NEUTRALIZING ANTIBODIES TO POLIO-MYELITIS VIRUS IN CAIRO, EGYPT12

1952 • 63 citations

Dengue virus infection of human skin fibroblasts in vitro production of IFN-?, IL-6 and GM-CSF

1992 • 62 citations

Epidemiology and genetics of multiple sclerosis.

1992 • 60 citations

Theiler's virus infection induces a specific cytotoxic T lymphocyte response

1991 • 57 citations

Neonatal infection with the Daniels strain of Theiler's murine encephalomyelitis virus.

1983 • 57 citations

Inhibition of Theiler's Virus-induced demylination in vivo by tumor necrosis factor alpha

1990 • 53 citations

Multiple Sclerosis: Basic Concepts and Hypothesis

1989 • 52 citations

Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice

1990 • 52 citations

Effect of cyclosporin A, silica quartz dust, and protease inhibitors on virus-induced demyelination

1986 • 50 citations

Erichrome Stain for Myelin on Osmicated Tissue Embedded in Glycol Methacrylate Plastic

1989 • 42 citations

Interleukin-6 induction in vitro in mouse brain endothelial cells and astrocytes by exposure to mouse hepatitis virus (MHV-4, JHM)

1993 • 41 citations

Elevation of Cerebrospinal Fluid Interleukin-6 Activity in Patients with Vasculitides and Central Nervous System Involvement

1993 • 39 citations

Theiler's virus-induced demyelination in mice immunosuppressed with anti-IgM and in mice expressing the xid gene

1990 • 39 citations

Role of T cell receptor V beta genes in Theiler's virus-induced demyelination of mice.

1992 • 37 citations

Cerebrospinal Fluid Levels of IL-6 in Patients with Acute Infections of the Central Nervous System

1992 • 32 citations

Production of random classes of immunoglobulins in brain tissue during persistent viral infection paralleled by secretion of interleukin-6 (IL-6) but not IL-4, IL-5, and gamma interferon

1991 • 29 citations

Human B-Cell Stimulatory Factor-2 Expressed in Escherichia Coli

1988 • 29 citations

Role of T cells in resistance to Theiler's virus infection

1991 • 28 citations

Interleukin-6 is constitutively produced by human CTL clones and is required to maintain their cytolytic function

1991 • 23 citations

Characterization and Specificity of Humoral Immune Responses to Theiler's Murine Encephalomyelitis Virus Capsid Proteins

1987 • 22 citations

Expression of human HLA-B27 transgene alters susceptibility to murine Theiler's virus-induced demyelination.

1991 • 19 citations

Increased transcription of interleukin-6 in the brains of mice with chronic enterovirus infection

1993 • 16 citations

Antigenic variants are not selected during persistent infection with Theiler's virus

1983 • 7 citations

Cerebrospinal fluid interleukin-6 and IgE in bacterial and viral meningitis.

1992 • 6 citations