Interleukin-6 production by U373 MG, a human astrocytoma cell line: different pathways involved in substance P and lipopolysaccharide activation

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

ENDOTOXINS AND DISEASE MECHANISMS

1987 • 1,119 citations

Neurotransmitter functions of mammalian tachykinins.

1993 • 1,101 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Soluble CD14 participates in the response of cells to lipopolysaccharide.

1992 • 695 citations

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1989 • 692 citations

Tachykinin receptors and tachykinin receptor antagonists

1993 • 649 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis

1991 • 330 citations

Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures

1991 • 304 citations

Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

1988 • 297 citations

Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60.

1987 • 263 citations

Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP.

1988 • 261 citations

Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patients.

1988 • 246 citations

Substance P raises neuronal membrane excitability by reducing inward rectification

1985 • 230 citations

A Multiple Cytokine- and Second Messenger-Responsive Element in the Enhancer of the Human Interleukin-6 Gene: Similarities with c-fosGene Regulation

1989 • 178 citations

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

1993 • 178 citations

Two types of calcium-dependent protein phosphorylations modulated by calmodulin antagonists. Naphthalenesulfonamide derivatives.

1982 • 156 citations

Differential inhibition of IL-1 and TNF-alpha mRNA expression by agents which block second messenger pathways in murine macrophages.

1988 • 152 citations

Pharmacological profile of a high affinity dipeptide NK₁ receptor antagonist, FK888

1992 • 146 citations

Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187.

1987 • 129 citations

Substance P receptor binding sites are expressed by glia in vivo after neuronal injury.

1989 • 120 citations

Proinflammatory and Antiinflammatory Cytokines in Multiple Sclerosis and Central Nervous System Acquired Immunodeficiency Syndrome

1992 • 120 citations

Substance P‐Induced Release of Prostaglandins from Astrocytes: Regional Specialisation and Correlation with Phosphoinositol Metabolism

1991 • 104 citations

Substance P stimulates IL-1 production by astrocytes via intracellular calcium

1992 • 101 citations

Tachykinin Receptors of the NK1 Type (Substance P) Coupled Positively to Phospholipase C on Cortical Astrocytes from the Newborn Mouse in Primary Culture

1989 • 100 citations

Substance P and astrocytes: stimulation of the cyclooxygenase pathway of arachidonic acid metabolism

1988 • 98 citations

Substance P enhances the secretion of tumor necrosis factor-alpha from neuroglial cells stimulated with lipopolysaccharide.

1994 • 96 citations

Production of interleukin-1 by microglia in response to substance P: role for a non-classical NK-1 receptor

1993 • 90 citations

Interleukin-6 secretion from human astrocytoma cells induced by substance P

1994 • 78 citations

Substance P immunoreactive astrocytes are present in multiple sclerosis plaques

1989 • 60 citations

Characterization of a Human NK₁ Tachykinin Receptor in the Astrocytoma Cell Line U 373 MG

1993 • 58 citations

Chloride channels in myocytes from rabbit colon are regulated by a pertussis toxin-sensitive G protein

1993 • 41 citations

Inhibition by cyclo-oxygenase inhibitors of interleukin-6 production by human peripheral blood mononuclear cells

1991 • 34 citations

TNF-alpha response of human monocyte-derived macrophages to Mycobacterium avium, serovar 4, is of brief duration and protein kinase C dependent.

1993 • 30 citations

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.

1993 • 27 citations

Tachykinin‐Stimulated Inositol Phospholipid Hydrolysis and Taurine Release from Human Astrocytoma Cells

1992 • 23 citations

Substance P stimulation of polyphosphoinositide hydrolysis in rat anterior pituitary membranes involves a GTP-dependent mechanism

1991 • 21 citations

Different susceptibility to neurokinin 1 receptor antagonists of substance P and septide-induced interleukin-6 release from U373 MG human astrocytoma cell line

1994 • 18 citations

Effects of tachykinins on [3H]taurine release from human astrocytoma cells (U-373 MG)

1991 • 14 citations

Stimulation of prostaglandin E2 production and induction of specific protein synthesis in rat peritoneal macrophages by a tumor promoter staurosporine

1993 • 3 citations