The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

Growth hormone receptor and serum binding protein: purification, cloning and expression

1987 • 1,540 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor

1991 • 819 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

1988 • 733 citations

Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor

1990 • 720 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

Nerve growth factor receptors on human melanoma cells in culture.

1977 • 670 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Induction of nerve growth factor receptor in Schwann cells after axotomy.

1986 • 614 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

The retrograde axonal transport of nerve growth factor

1974 • 598 citations

Cloning and Sequencing of Porcine LH-hCG Receptor cDNA: Variants Lacking Transmembrane Domain

1989 • 568 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

1987 • 555 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding properties

1988 • 539 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells.

1984 • 503 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

Soluble cytokine receptors are present in normal human urine.

1989 • 441 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

cDNA sequences of two inducible T-cell genes.

1989 • 392 citations

Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor.

1990 • 375 citations

Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system

1990 • 375 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons

1989 • 331 citations

Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies.

1984 • 318 citations

Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association

1981 • 302 citations

Keeping track of neurotrophin receptors

1991 • 297 citations

Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors

1991 • 296 citations

Trkl3 mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor

1991 • 294 citations

A constitutive promoter directs expression of the nerve growth factor receptor gene.

1988 • 280 citations

Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system

1987 • 268 citations

Nerve growth factor receptor molecules in rat brain.

1986 • 268 citations

Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states.

1980 • 255 citations

Expression of NGF receptor in the developing and adult primate central nervous system

1988 • 251 citations

Developmental and regional expression of β-nerve growth factor receptor mRNA in the chick and rat

1988 • 245 citations

NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat

1989 • 243 citations

Nerve growth factor promotes human hemopoietic colony growth and differentiation.

1988 • 241 citations

Expression of Functional Nerve Growth Factor Receptors After Gene Transfer

1989 • 235 citations

Regulation of Alloreactivity in Vivo by a Soluble Form of the Interleukin-1 Receptor

1990 • 235 citations

A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins.

1982 • 220 citations

Nerve growth factor rapidly induces c-fos mRNA in PC12 rat pheochromocytoma cells.

1986 • 220 citations

Serum transferrin receptor is a truncated form of tissue receptor.

1990 • 215 citations

A v-myc-immortalized sympathoadrenal progenitor cell line in which neuronal differentiation is initiated by FGF but not NGF

1990 • 205 citations

Molecular characteristics of nerve growth factor receptors on PC12 cells.

1985 • 200 citations

Nerve growth factor mRNA and protein in the testis and epididymis of mouse and rat.

1988 • 200 citations

A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.

1990 • 198 citations

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

1984 • 197 citations

Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system

1989 • 171 citations

The localization and distribution of high affinity β-nerve growth factor binding sites in the central nervous system of the adult rat. A light microscopic autoradiographic study using [125I]β-nerve growth factor

1987 • 169 citations

Localization of nerve growth factor receptor messenger RNA and protein in the adult rat brain

1989 • 169 citations

Histochemical characterization of sensory neurons with high-affinity receptors for nerve growth factor

1989 • 165 citations

The spatial and temporal pattern of beta NGF receptor expression in the developing chick embryo.

1985 • 163 citations

Characterization of the human melanoma nerve growth factor receptor.

1985 • 162 citations

A single Mr approximately 103,000 125I-beta-nerve growth factor-affinity-labeled species represents both the low and high affinity forms of the nerve growth factor receptor.

1986 • 159 citations

Expression of β-Nerve Growth Factor Receptor mRNA in Sertoli Cells Downregulated by Testosterone

1990 • 154 citations

Molecular investigations on the high-affinity nerve growth factor receptor

1991 • 154 citations

The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.

1991 • 153 citations

Differential expression of the nerve growth factor receptor gene in multiple brain areas

1988 • 146 citations

Identification of a truncated form of the nerve growth factor receptor.

1988 • 145 citations

Nerve growth factor induces mast cell degranulation without changing intracellular calcium levels

1986 • 142 citations

Immunohistochemical analysis of nerve growth factor receptor expression in normal and malignant human tissues.

1988 • 141 citations

Nerve Growth Factor Regulates Expression of the Nerve Growth Factor Receptor Gene in Adult Sensory Neurons

1990 • 136 citations

Transient expression of NGF-receptor-like immunoreactivity in postnatal rat brain and spinal cord

1988 • 134 citations

Induction by NGF of Meiotic Maturation of Xenopus Oocytes Expressing the trk Proto-Oncogene Product

1991 • 133 citations

Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling.

1981 • 133 citations

trkB, a Neural Receptor Protein-Tyrosine Kinase: Evidence for a Full-Length and Two Truncated Receptors

1991 • 131 citations

Nerve growth factor receptors on cultured rat Schwann cells

1988 • 131 citations

Uptake of nerve growth factor along peripheral and spinal axons of primary sensory neurons

1984 • 125 citations

Inhibition of Tyrosine Kinase Activity of the Epidermal Growth Factor (EGF) Receptor by a Truncated Receptor Form That Binds to EGF: Role for Interreceptor Interaction in Kinase Regulation

1989 • 125 citations

Molecular and Biochemical Characterization of the Human trk Proto-Oncogene

1989 • 124 citations

Regulation of nerve growth factor receptor gene expression by nerve growth factor in the developing peripheral nervous system.

1991 • 121 citations

Structure and developmental expression of the chicken NGF receptor

1990 • 120 citations

Chimeric NGF-EGF Receptors Define Domains Responsible for Neuronal Differentiation

1991 • 116 citations

Serum Form of the Rat Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor Is Truncated in the Carboxyl-terminal Domain

1989 • 114 citations

Multiple functions for NGF receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity

1990 • 114 citations

Expression of the NGF receptor gene in sensory neurons and their cutaneous targets prior to and during innervation

1990 • 113 citations

Affinity labeling and partial purification of nerve growth factor receptors from rat pheochromocytoma and human melanoma cells.

1983 • 99 citations

Alteration of binding properties and cytoskeletal attachment of nerve growth factor receptors in PC12 cells by wheat germ agglutinin.

1982 • 98 citations

Concentration-dependent regulation of neuronal gene expression by nerve growth factor

1992 • 94 citations

Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding.

1990 • 94 citations

Effects of nerve crush and transection on mRNA levels for nerve growth factor receptor in the rat facial motoneurons

1991 • 91 citations

A functional soluble extracellular region of the platelet-derived growth factor (PDGF) beta-receptor antagonizes PDGF-stimulated responses.

1991 • 89 citations

Sequestration of 125I-labeled beta nerve growth factor by sympathetic neurons.

1980 • 89 citations

A Monoclonal Antibody Against Nerve Growth Factor Receptor: Immunohistochemical Analysis of Normal and Neoplastic Human Tissue

1989 • 89 citations

Purification and Amino Terminal Sequencing of Human Melanoma Nerve Growth Factor Receptor

1987 • 87 citations

Properties of the nerve growth factor receptor of a clonal line of rat pheochromocytoma (PC12) cells

1979 • 86 citations

Nerve growth factor (NGF) receptor expression in chicken cranial development

1987 • 85 citations

Purkinje cells of adult rat cerebellum express nerve growth factor receptor immunoreactivity: light microscopic observations

1988 • 84 citations

Disruption of cysteine-rich repeats of the p75 nerve growth factor receptor leads to loss of ligand binding

1991 • 83 citations

Tumorigenic poxviruses: Genomic organization and dna sequence of the telomeric region of the shope fibroma virus genome

1987 • 75 citations

Nerve Growth Factor (NGF) Induces Neuronal Differentiation in Neuroblastoma Cells Transfected with the NGF Receptor cDNA

1990 • 72 citations

A Constitutive Promoter Directs Expression of the Nerve Growth Factor Receptor Gene

1988 • 72 citations

Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation.

1990 • 71 citations

Characterization of functional nerve growth factor‐receptors in a CNS glial cell line: Monoclonal antibody 217c recognizes the nerve growth factor‐receptor on C6 glioma cells

1990 • 66 citations

Properties of the nerve growth factor receptor. Relationship between receptor structure and affinity.

1985 • 66 citations

Expression of nerve growth factor receptor mRNA during early development of the chicken embryo: emphasis on cranial ganglia

1990 • 65 citations

Expression of high- and low-affinity nerve growth factor receptors by Purkinje cells in the developing rat cerebellum

1989 • 65 citations

Factors controlling the expression of the NGF receptor in PC12 cells

1988 • 64 citations

Recombinant human nerve growth factor is biologically active and labels novel high-affinity binding sites in rat brain.

1991 • 64 citations

Cloning of a potentially soluble receptor for human GM-CSF

1990 • 64 citations

A Truncated, Secreted Form of the Epidermal Growth Factor Receptor Is Encoded by an Alternatively Spliced Transcript in Normal Rat Tissue

1990 • 64 citations

Identification, purification, and characterization of truncated forms of the human nerve growth factor receptor

1989 • 63 citations

Soluble interleukin 2 receptors are released from the cell surface of normal murine B lymphocytes stimulated with interleukin 5.

1988 • 60 citations

Nerve growth factor binding domain of the nerve growth factor receptor.

1991 • 59 citations

Nerve growth factor receptors on chick embryo sympathetic ganglion cells: binding characteristics and development

1986 • 59 citations

Isolation and characterization of two novel rat ovarian lactogen receptor cDNA species

1990 • 57 citations

Identification of a conserved protein motif in a group of growth factor receptors

1990 • 57 citations

Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex.

1991 • 55 citations

Change in state of nerve growth factor receptor. Modulation of receptor affinity by wheat germ agglutinin.

1983 • 53 citations

Dissociation kinetics of 125I-nerve growth factor from cell surface receptors. Acceleration by unlabeled ligand and its relationship to negative cooperativity.

1981 • 50 citations

A soluble form of the interleukin‐1 receptor produced by a human B cell line

1990 • 50 citations

Regulation of Schwann cell nerve growth factor receptor by cyclic adenosine 3′,5′‐monophosphate

1988 • 48 citations

A comparison of binding properties and structure of NGF receptor on PC12 pheochromocytoma and A875 melanoma cells

1983 • 48 citations

Internalization and cycling of nerve growth factor in PC12 cells: Interconversion of type II (fast) and type I (slow) nerve growth factor receptors

1988 • 47 citations

.beta. Nerve growth factor binding to PC12 cells. Association kinetics and cooperative interactions

1986 • 43 citations

Nerve growth factor receptors in rat spinal cord: An autoradiographic and immunohistochemical study

1987 • 40 citations

Modification of nerve growth factor receptor properties by wheat germ agglutinin.

1983 • 40 citations

Specific neuronal expression of human NGF receptors in the basal forebrain and cerebellum of transgenic mice

1990 • 38 citations

Purification and characterization of the recombinant extracellular domain of human nerve growth factor receptor expressed in a baculovirus system.

1990 • 38 citations

Increased nerve growth factor receptor mRNA in contused rat spinal cord

1990 • 37 citations

Developmental study of nerve growth factor receptor mRNA expression in the postnatal rat cerebellum

1990 • 36 citations

Properties of receptors for nerve growth factor in the mature rat nervous system

1987 • 36 citations

Decreased levels of nerve growth factor receptor on dexamethasone‐treated PC12 cells

1988 • 32 citations

Generation of the truncated form of the nerve growth factor receptor by rat Schwann cells. Evidence for post-translational processing.

1991 • 29 citations

Internalization of nerve growth factor by PC12 cells. A description of cellular pools.

1988 • 29 citations

Nerve growth factor receptor from rabbit sympathetic ganglia membranes. Relationship between subforms.

1986 • 28 citations

Native avian c-erbB gene expresses a secreted protein product corresponding to the ligand-binding domain of the receptor.

1991 • 28 citations

Pathobiochemistry of CO poisoning

1990 • 27 citations

Relationship among types of nerve growth factor receptors on PC12 cells.

1990 • 26 citations

Nerve growth factor supports growth of rat skeletal myotubes in culture

1987 • 25 citations

Developmental regulation of human truncated nerve growth factor receptor

1991 • 25 citations

Molecular Analysis of the Nerve Growth Factor Receptor

1988 • 23 citations

The ontogeny of specific retrograde transport of nerve growth factor by motoneurons of the brainstem and spinal cord

1990 • 22 citations

Effects of tunicamycin on NGF binding and neurite outgrowth in PC12 cells

1985 • 21 citations

Regulation of schwann cell surface and truncated nerve growth factor receptors in vitro by axonal components

1990 • 20 citations

Transient expression of full-length and truncated forms of the human nerve growth factor receptor

1990 • 8 citations