Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement.

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis

1991 • 449 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Current protocols in immunology

1992 • 356 citations

Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.

1991 • 349 citations

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.

1993 • 318 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.

1992 • 287 citations

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck

1991 • 284 citations

Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk

1993 • 283 citations

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

1993 • 271 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Tyrosine phosphorylation of the gamma subunit of Fc gamma receptors, p72syk, and paxillin during Fc receptor-mediated phagocytosis in macrophages.

1994 • 244 citations

The Src family of tyrosine protein kinases in hemopoietic signal transduction

1992 • 221 citations

B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase

1991 • 204 citations

Nonreceptor tyrosine protein kinases.

1993 • 183 citations

Effects of p56lck deficiency on the growth and cytolytic effector function of an interleukin-2-dependent cytotoxic T-cell line.

1992 • 175 citations

CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor

1990 • 174 citations

Alterations of the Lymphocyte-Specific Protein Tyrosine Kinase (p56^lck) during T-Cell Activation

1988 • 169 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor.

1992 • 146 citations

Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking.

1992 • 141 citations

Igα and Igβ Are Functionally Homologous to the Signaling Proteins of the T-Cell Receptor

1994 • 52 citations

Characterization of the T cell antigen receptor - p60^fyn protein tyrosine kinase association by chemical cross-linking

1992 • 46 citations

Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes.

1994 • 39 citations

Cross-linking of surface immunoglobulin activates src-related tyrosine kinases in WEHI 231 cells

1992 • 38 citations

Signal transduction through a biomolecular receptor tyrosine protein kinase composed of a platelet-derived growth factor receptor-CD4 chimera and the nonreceptor tyrosine protein kinase Lck.

1993 • 16 citations