Testing an “In-Out” Targeting Procedure for Making Subtle Genomic Modifications in Mouse Embryonic Stem Cells

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

1985 • 978 citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1987 • 786 citations

Replacement of chromosome segments with altered DNA sequences constructed in vitro.

1979 • 779 citations

High frequency targeting of genes to specific sites in the mammalian genome

1986 • 619 citations

THE EFFECTS OF UNEQUAL CROSSING OVER AT THE BAR LOCUS IN DROSOPHILA

1925 • 432 citations

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

1989 • 423 citations

Chromosomal Rearrangements and the Evolution of Haptoglobin Genes

1962 • 256 citations

Targeted mutation of the Hprt gene in mouse embryonic stem cells.

1988 • 226 citations

Homology Requirement for Efficient Gene Conversion Between Duplicated Chromosomal Sequences in Mammalian Cells

1987 • 207 citations

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

1989 • 200 citations

Homologous integration in mammalian cells without target gene selection.

1988 • 172 citations

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination

1989 • 166 citations

The HPRT locus

1979 • 146 citations

Metabolic Cooperation between Cells

1981 • 144 citations

Evidence for intrachromosomal gene conversion in cultured mouse cells

1983 • 124 citations

Homologous Recombination between Repeated Chromosomal Sequences in Mouse Cells

1984 • 114 citations

Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells.

1990 • 103 citations

Introduction of specific point mutations into RNA polymerase II by gene targeting in mouse embryonic stem cells: evidence for a DNA mismatch repair mechanism.

1990 • 33 citations