Double-strand gap repair in a mammalian gene targeting reaction.

The double-strand-break repair model for recombination

1983 • 2,468 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Transformation of yeast.

1978 • 2,267 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

A mechanism for gene conversion in fungi

1964 • 1,459 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

A mechanism for gene conversion in fungi

2007 • 1,149 citations

Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination

1985 • 978 citations

A general model for genetic recombination.

1975 • 890 citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1987 • 786 citations

High frequency targeting of genes to specific sites in the mammalian genome

1986 • 619 citations

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

1989 • 423 citations

ENZYMES OF GENERAL RECOMBINATION

1987 • 333 citations

HOMOLOGOUS RECOMBINATION IN MAMMALIAN CELLS

1989 • 262 citations

Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA.

1984 • 251 citations

Recombinant fragment assay for gene targetting based on the polymerase chain reaction

1988 • 192 citations

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells.

1991 • 179 citations

Homologous integration in mammalian cells without target gene selection.

1988 • 172 citations

Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences.

1985 • 165 citations

Homologous Recombination between Repeated Chromosomal Sequences in Mouse Cells

1984 • 114 citations

High frequency of homologous recombination in mammalian cells between endogenous and introduced SV40 genomes

1985 • 100 citations

Effect of insertions, deletions, and double-strand breaks on homologous recombination in mouse L cells.

1985 • 94 citations

Effect of double-strand breaks on homologous recombination in mammalian cells and extracts.

1985 • 84 citations

Homologous Recombination in Hybridoma Cells: Dependence on Time and Fragment Length

1990 • 80 citations

Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation.

1986 • 73 citations

Double-strand gap repair results in homologous recombination in mouse L cells.

1986 • 67 citations

Conservative intrachromosomal recombination between inverted repeats in mouse cells: association between reciprocal exchange and gene conversion.

1988 • 58 citations

Accurate modification of a chromosomal plasmid by homologous recombination in human cells.

1987 • 54 citations

Gene Conversion Adjacent to Regions of Double-Strand Break Repair

1988 • 53 citations

Testing an “In-Out” Targeting Procedure for Making Subtle Genomic Modifications in Mouse Embryonic Stem Cells

1991 • 46 citations

Effect of Double-Strand Breaks on Homologous Recombination in Mammalian Cells and Extracts

1985 • 45 citations

Homologous recombination in hybridoma cells: dependence on time and fragment length.

1990 • 41 citations

Gene conversion adjacent to regions of double-strand break repair.

1988 • 38 citations

Effect of Insertions, Deletions, and Double-Strand Breaks on Homologous Recombination in Mouse L Cells

1985 • 21 citations

Rescue of chromosomal T-antigen sequences onto extrachromosomally replicating, defective simian virus 40 DNA by homologous recombination.

1986 • 16 citations

Enzymes Of General Recombination

1987 • 16 citations

Homologous Recombination In Mammalian Cells

1989 • 13 citations

Rescue of Chromosomal T-Antigen Sequences onto Extrachromosomally Replicating, Defective Simian Virus 40 DNA by Homologous Recombination

1986 • 9 citations