Target Frequency and Integration Pattern for Insertion and Replacement Vectors in Embryonic Stem Cells

The double-strand-break repair model for recombination

1983 • 2,468 citations

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting

1990 • 1,650 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

Yeast transformation: a model system for the study of recombination.

1981 • 1,491 citations

A mechanism for gene conversion in fungi

1964 • 1,459 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

A general model for genetic recombination.

1975 • 890 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

1987 • 786 citations

Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

1984 • 435 citations

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

1989 • 423 citations

Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter

1987 • 361 citations

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

1989 • 355 citations

Germ-Line Transmission of a c- abl Mutation Produced by Targeted Gene Disruption in ES Cells

1989 • 285 citations

Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA.

1984 • 251 citations

Targeted mutation of the Hprt gene in mouse embryonic stem cells.

1988 • 226 citations

Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination.

1989 • 216 citations

Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells

1989 • 200 citations

Targeting of Nonexpressed Genes in Embryonic Stem Cells Via Homologous Recombination

1989 • 109 citations

Differential Effects of Polyadenylation Regions on Gene Expression in Mammalian Cells

1986 • 75 citations

Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.

1990 • 67 citations

Analysis of homologous recombination in cultured mammalian cells in transient expression and stable transformation assays

1986 • 50 citations

Effect of Double-Strand Breaks on Homologous Recombination in Mammalian Cells and Extracts

1985 • 45 citations