Interleukin 1, tumor necrosis factor, and interleukin 6 as mediators of cartilage destruction

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage

1986 • 742 citations

Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

1985 • 679 citations

Induction of β2-interferon by tumor necrosis factor: A homeostatic mechanism in the control of cell proliferation

1986 • 577 citations

Detection of tumor necrosis factor α but not tumor necrosis factor β in rheumatoid arthritis synovial fluid and serum

1988 • 570 citations

Fluorescein isothiocyanate-labeled casein assay for proteolytic enzymes

1984 • 555 citations

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization.

1986 • 515 citations

Establishment of an interleukin 6 (IL 6)/B cell stimulatory factor 2‐dependent cell line and preparation of anti‐IL 6 monoclonal antibodies

1988 • 308 citations

Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro

1984 • 281 citations

Cytokines in synovial fluid: II. The presence of tumour necrosis factor and interferon.

1988 • 191 citations

Collagenase and collagenolytic activity in human osteoarthritic cartilage

1983 • 168 citations

Human monocyte or recombinant interleukin 1's are specific for the secretion of a metalloproteinase from chondrocytes.

1987 • 117 citations

Expression of IL-1 genes in human and bovine chondrocytes: A mechanism for autocrine control of cartilage matrix degradation

1986 • 113 citations

Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2)

1988 • 87 citations

Two latent metalloproteases of human articular cartilage that digest proteoglycan.

1984 • 66 citations

Interleukin 1 preferentially stimulates the production of tissue-type plasminogen activator by human articular chondrocytes

1987 • 63 citations

Catabolin???A Cartilage Catabolic Factor from Synovium

1981 • 62 citations

Activation of rabbit articular chondrocytes by recombinant human cytokines.

1987 • 50 citations

Proteoglycan- and Collagen-Degrading Enzymes from Human Interleukin 1-Stimulated Chondrocytes from Several Species: Proteoglycanase and Collagenase Inhibitors as Potentially New Disease-Modifying Antiarthritic Agents

1986 • 40 citations

The role of plasminogen in interleukin-1 mediated cartilage degradation.

1988 • 39 citations

Synthesis of interleukin-1-like activity by normal rat chondrocytes in culture

1988 • 35 citations

Effects of Interleukin-1 and Anti-Inflammatory Drugs on the Degradation of Human Articular Cartilage

1988 • 32 citations

Rheumatoid adherent synovial cells produce B cell differentiation factor activity neutralizable by antibody to B cell stimulatory factor-2/interleukin 6.

1988 • 20 citations

Stimulation of Interleukin 6‐Like B‐Cell Differentiation Factor Production in Human Adherent Synovial Cells by Recombinant Interleukin 1

1989 • 11 citations

a micro-assay method of collagenase activity and its application in the study of collagen metabolism in pathological tissues

1984 • 10 citations