Gene Transfer into Experimental Brain Tumors Mediated by Adenovirus, Herpes Simplex Virus, and Retrovirus Vectors

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

The Basic Science of Gene Therapy

1993 • 1,767 citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1992 • 1,530 citations

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

1991 • 994 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

Grading of astrocytomas: A simple and reproducible method

1988 • 902 citations

Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer.

1987 • 881 citations

An Adenovirus Vector for Gene Transfer into Neurons and Glia in the Brain

1993 • 746 citations

Production of Plaques in Monolayer Tissue Cultures by Single Particles of an Animal Virus

1952 • 644 citations

Transfer of a foreign gene into the brain using adenovirus vectors

1993 • 538 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats.

1993 • 442 citations

Gene Therapy for the Treatment of Brain Tumors Using Intra-Tumoral Transduction with the Thymidine Kinase Gene and Intravenous Ganciclovir. National Institutes of Health

1993 • 420 citations

Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors

1993 • 387 citations

National survey of patterns of care for brain-tumor patients

1989 • 385 citations

Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.

1989 • 360 citations

Ribonucleotide reductase: regulation, regulation, regulation

1992 • 305 citations

Regulation of the proliferating cell nuclear antigen cyclin and thymidine kinase mRNA levels by growth factors.

1988 • 235 citations

Lymphoma Regression Induced by Ganciclovir in Mice Bearing a Herpes Thymidine Kinase Transgene

1990 • 208 citations

S-Phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs

1990 • 178 citations

Reduction and Elimination of Encephalitis in an Experimental Glioma Therapy Model with Attenuated Herpes Simplex Mutants that Retain Susceptibility to Acyclovir

1993 • 177 citations

The 9L rat brain tumor: Description and application of an animal model

1981 • 166 citations

Inhibition of lymphocyte function by glioblastoma-derived transforming growth factor β2

1989 • 153 citations

Treatment of glioma by engineered interleukin 4-secreting cells.

1993 • 149 citations

In situ characterization, clonogenic potential, and antitumor cytolytic activity of T lymphocytes infiltrating human brain cancers

1988 • 126 citations

β-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse

1988 • 116 citations

Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation.

1988 • 107 citations

Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase.

1992 • 101 citations

Inducible proteins binding to the murine thymidine kinase promoter in late G1/S phase.

1991 • 79 citations

S-phase-specific regulation by deletion mutants of the human thymidine kinase promoter.

1989 • 78 citations

A three-dimensional micro-organ culture system optimized for in vitro growth of human malignant brain tumors

1991 • 10 citations

A Three-Dimensional Micro-Organ Culture System Optimized for in Vitro Growth of Human Malignant Brain Tumors

1991 • 4 citations