Immunomodifiers in Vaccines

Antigen-Presenting Function of the Macrophage

1984 • 1,164 citations

Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives

1974 • 1,038 citations

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

1982 • 854 citations

Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses

1984 • 696 citations

Vaccinia virus: a selectable eukaryotic cloning and expression vector.

1982 • 663 citations

Liposomes as immunological adjuvants

1974 • 659 citations

Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus.

1982 • 506 citations

Tapping the immunological repertoire to produce antibodies of predetermined specificity

1982 • 473 citations

Selective induction of DNA synthesis in T and B lymphocytes

1972 • 411 citations

An update on human interleukin-1: From molecular biology to clinical relevance

1985 • 372 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

STUDIES ON THE O ANTIGEN OF SALMONELLA TYPHOSA

1956 • 356 citations

Studies on the capacity of B cells to serve as antigen-presenting cells.

1981 • 349 citations

A generalized technique for deletion of specific genes in large genomes: a gene 22 of herpes simplex virus 1 is not essential for growth

1981 • 336 citations

Induction of Plasma-Cell Neoplasms in Strain BALB/c Mice with Mineral Oil and Mineral Oil Adjuvants

1962 • 311 citations

Sensitization and Antibody Formation after Injection of Tubercle Bacilli and Paraffin Oil.

1937 • 311 citations

THE MITOGENIC EFFECT OF LIPOPOLYSACCHARIDE ON BONE MARROW-DERIVED MOUSE LYMPHOCYTES

1973 • 310 citations

Carrier-induced epitopic suppression, a major issue for future synthetic vaccines.

1985 • 298 citations

Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: Possible application to vaccine production

1981 • 296 citations

The chemical structure of the cord factor of Mycobacterium tuberculosis

1956 • 294 citations

Live recombinant vaccinia virus protects chimpanzees against hepatitis B

1984 • 290 citations

Construction of live vaccines using genetically engineered poxviruses: biological activity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen and the herpes simplex virus glycoprotein D.

1984 • 287 citations

Current Status of Immunological Adjuvants

1986 • 283 citations

Construction of Synthetic Immunogen: Use of New T-Helper Epitope on Malaria Circumsporozoite Protein

1987 • 270 citations

CARRIER FUNCTION IN ANTI-HAPTEN IMMUNE RESPONSES

1970 • 265 citations

Vaccine Adjuvants

1980 • 242 citations

Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon.

1983 • 236 citations

Stimulation of B-lymphocytes by endotoxin. Reactions of thymus-deprived mice and karyotypic analysis of dividing cells in mice bearing T 6 T 6 thymus grafts.

1972 • 232 citations

Antibodies That React with Predetermined Sites on Proteins

1983 • 221 citations

Carrier-priming leads to hapten-specific suppression

1980 • 220 citations

Biologically Active Components from Mycobacterial Cell Walls. I. Isolation and Composition of Cell Wall Skeleton and Component P 3

1974 • 217 citations

Modulation of the immune response by a synthetic adjuvant and analogs.

1976 • 204 citations

Antibody to hepatitis B surface antigen after a single inoculation of uncoupled synthetic HBsAg peptides

1982 • 198 citations

The adjuvanticity of interleukin 1 in vivo.

1983 • 197 citations

Components of mycobacteria and muramyl dipeptide with adjuvant activity induce lymphocyte activating factor

1980 • 181 citations

Macrophage activation: priming activity from a T-cell hybridoma is attributable to interferon-gamma.

1983 • 177 citations

The adjuvant activity of nonionic block polymer surfactants. I. The role of hydrophile-lipophile balance.

1981 • 175 citations

Synthetic lipopeptide analogs of bacterial lipoprotein are potent polyclonal activators for murine B lymphocytes.

1985 • 174 citations

Relationship of the Structure of Bacterial Lipopolysaccharides to Its Function in Mitogenesis and Adjuvanticity

1973 • 172 citations

Location and Chemical Synthesis of a Pre-S Gene Coded Immunodominant Epitope of Hepatitis B Virus

1984 • 170 citations

Distinctive adjuvanticity of synthetic analogs of mycobacterial water-soluble components

1976 • 160 citations

Glucan-induced enhancement of host resistance to selected infectious diseases

1980 • 145 citations

Adjuvant activity of monomeric bacterial cell wall peptidoglycans

1974 • 144 citations

Saponin adjuvants

1974 • 139 citations

Muramyl peptides

1981 • 135 citations

Immunological Specificity of the Secondary Response with Dinitrophenylated Proteins.

1963 • 129 citations

Biologically Active Components From Mycobacterial Cell Walls. II. Suppression and Regression of Strain-2 Guinea Pig Hepatoma

1974 • 129 citations

Lipid A and Immunotherapy

1984 • 126 citations

Biological Response Modifiers

1989 • 125 citations

Adjuvant activity of mycobacterial fractions: adjuvant activity of synthetic N-acetylmuramyl-dipeptide and the related compounds

1976 • 125 citations

Adjuvant-free IgG responses induced with antigen coupled to antibodies against class II MHC

1987 • 125 citations

Antibodies to Hepatitis B Surface Antigen Potentiate the Response of Human T Lymphocyte Clones to the Same Antigen

1984 • 119 citations

Stimulation of B-Lymphocytes by Endotoxin

1972 • 117 citations

Antiviral effect on MS-2 coliphage obtained with a synthetic antigen.

1976 • 117 citations

Biologically active components from mycobacterial cell walls

1975 • 116 citations

Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees.

1983 • 116 citations

Successful immunization with a totally synthetic diphtheria vaccine.

1982 • 115 citations

The comparative selectivity of adjuvants for humoral and cell-mediated immunity. II. Effect on delayed-type hypersensitivity in the mouse and guinea pig, and cell-mediated immunity to tumour antigens in the mouse of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin.

1980 • 112 citations

Freund's adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition.

1974 • 108 citations

Immunogenicity of a synthetic HBsAg peptide: Enhancement by conjugation to a fatty acid carrier

1984 • 102 citations

The comparative selectivity of adjuvants for humoral and cell-mediated immunity. I. Effect on the antibody response to bovine serum albumin and sheep red blood cells of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin.

1980 • 98 citations

Plasmodium knowlesi Sporozoite Antigen: Expression by Infectious Recombinant Vaccinia Virus

1984 • 96 citations

Immunopharmacology of glucan: a broad spectrum enhancer of host defense mechanisms

1983 • 95 citations

Immunostimulant activities of a lipophilic muramyl dipeptide derivative and of desmuramyl peptidolipid analogs

1980 • 95 citations

Biological activities of synthetic lipid A analogs: pyrogenicity, lethal toxicity, anticomplement activity, and induction of gelation of Limulus amoebocyte lysate

1984 • 92 citations

USE OF ADJUVANTS IN STUDIES ON INFLUENZA IMMUNIZATION

1953 • 89 citations

Specific monoclonal IgM is a potent adjuvant in murine malaria vaccination

1983 • 88 citations

Enhancement of antigenic potency in vitro and immunogenicity in vivo by coupling the antigen to anti-immunoglobulin.

1986 • 85 citations

STUDIES ON ARTIFICIAL ANTIGENS

1963 • 84 citations

Humoral and cellular immunity to hepatitis B virus-derived antigens: comparative activity of Freund complete adjuvant alum, and liposomes

1980 • 81 citations

STUDIES ON THE CHEMISTRY OF THE CORD FACTOR OF MYCOBACTERIUM TUBERCULOSIS

1955 • 81 citations

Tuftsin, Thr-Lys-Pro-Arg

1981 • 79 citations

Nonoverlapping T and B cell determinants on an hepatitis B surface antigen pre-S(2) region synthetic peptide.

1986 • 78 citations

A synthetic analogue of Escherichia coli lipoprotein, tripalmitoyl pentapeptide, constitutes a potent immune adjuvant.

1986 • 74 citations

Tuftsin, Thr-Lys-Pro-Arg

1981 • 73 citations

Immunological castration of male mice by a totally synthetic vaccine administered in saline.

1982 • 73 citations

Antiviral response elicited by a completely synthetic antigen with built-in adjuvanticity.

1980 • 70 citations

Mineral oil adjuvants: biological and chemical studies.

1972 • 66 citations

Molecular Immunogenicity of Bacterial Lipopolysaccharide Antigens: Establishing a Quantitative System

1971 • 65 citations

LONG-TERM MORTALITY FOLLOW-UP OF ARMYRECRUITS WHO RECEIVED ADJUVANT INFLUENZA VIRUS VACCINE IN 1951–19531

1972 • 62 citations

Adjuvant influenza vaccines.

1969 • 59 citations

Immunological Tolerance

1969 • 59 citations

In vivo immunostimulation by tuftsin

1978 • 56 citations

In vivo regulation of humoral and cellular immune reponses of mice by a synthetic adjuvant, N-acetyl-muramyl-l-alanyl-d-isoglutamine, muramyl dipeptide for MDP

1979 • 53 citations

Adjuvants and Immune Regulation by Lymphoid Cells

1980 • 53 citations

Use of Temperature-Sensitive and Cold-Adapted Mutant Viroses in Immunoprophylaxis of Acute Respiratory Tract Disease

1980 • 52 citations

Polyclonal activation of human B lymphocytes by Fc fragments. I. Characterization of the cellular requirements for Fc fragment-mediated polyclonal antibody secretion by human peripheral blood B lymphocytes.

1981 • 49 citations

Specific Mitogenic Activity of 8-Br-Guanosine 3′,5′-Monophosphate (Br-Cyclic GMP) on B Lymphocytes

1975 • 47 citations

Biological activities of endotoxins detoxified by alkylation

1975 • 46 citations

Biopolymeric controlled release systems

1984 • 45 citations

Immunization against experimental murine salmonellosis with liposome-associated O-antigen

1985 • 42 citations

New Metabolizable Immunologic Adjuvant for Human Use. I. Development and Animal Immune Response

1964 • 42 citations

Properties of Conjugated Protein Immunogens Which Selectively Stimulate Delayed-Type Hypersensitivity

1975 • 39 citations

Epitope specific immunity elicited by a synthetic streptococcal antigen without carrier or adjuvant

1983 • 39 citations

Derivatized guanine nucleosides: a new class of adjuvant for in vitro antibody responses.

1983 • 38 citations

The effects of beryllium and other adjuvants on Ia expression by macrophages.

1985 • 37 citations

Adjuvants and immune regulation by lymphoid cells

1979 • 35 citations

Induction of resistance to tuberculosis in mice with defined components of mycobacteria and with some unrelated materials.

1982 • 33 citations

Regulation of antibody response in different immunoglobulin classes. VI. Selective suppression of IgE response by administration of antigen-conjugated muramylpeptides.

1979 • 32 citations

Influence of a synthetic adjuvant (MDP) on qualitative and quantitative changes of serum globulins.

1978 • 31 citations

Cytodynamics of the Distinctive Immune Response Produced in Regional Lymph Nodes by Salmonella Somatic Polysaccharide

1966 • 31 citations

Adjuvant Activity of a Novel Metabolizable Lipid Emulsion with Inactivated Viral Vaccines

1980 • 30 citations

Demonstration of muramyl dipeptide (MDP)-induced T suppressor cells responsible for MDP immunosuppressive activity

1982 • 29 citations

Postimmunization Clearance of Liposome Entrapped Adenovirus Type 5 Hexon

1982 • 29 citations

A ten-year study of repository injections of allergens: local reactions and their management.

1972 • 28 citations

Biological activity of chemically synthesized analogues of lipid A. Demonstration of adjuvant effect in hapten-sensitized liposomal system.

1982 • 28 citations

Tumor regression after intralesional injection of mycobacterial components emulsified in 2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene (squalene), 2,6,10,15,19,23-hexamethyltetracosane (squalane), peanut oil, or mineral oil.

1979 • 28 citations

Immunoadjuvant activity of synthetic N-acetyl muramyl dipeptide

1978 • 26 citations

Activation of Lymphocyte Populations with Concanavalin A or with Lipoprotein and Lipopeptide from the Outer Cell Wall of Escherichia coli Correlation of Early Membrane Changes with Induction of Macromolecular Synthesis

1981 • 25 citations

Modulation of carrier-induced epitopic suppression by Bordetella pertussis components and muramyl peptide

1987 • 24 citations

Absence of Binding of MDP, a Synthetic Immunoadjuvant, to Anti-Peptidoglycan Antibodies

1978 • 22 citations

Efficient genetically controlled formation of antibody to a synthetic antigen [poly(LTyr, LGlu)-poly(DLAla)- -poly(LLys)] covalently bound to a synthetic adjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine).

1980 • 22 citations

Studies for safety of adjuvant 65.

1972 • 22 citations

Induction, in vivo and in vitro, of macrophage membrane interleukin-1 by adjuvant-active synthetic muramyl peptides

1987 • 21 citations

Manifold amplification of in vivo immunity in normal and immunodeficient mice by ribonucleosides derivatized at C8 of guanine.

1983 • 21 citations

Regulation of Antibody Response in Different Immunoglobulin Classes

1979 • 20 citations

Intralesional immunotherapy of malignant melanoma with mycobacterium smegmatis cell wall skeleton combined with trehalose dimycolate (p3)

1979 • 20 citations

Mitogenic Activities of Lipid A and Liposome-Associated Lipid A: Effects of Epitope Density

1984 • 19 citations

Biological Activity of Chemically Synthesized Analogues of Lipid A

1982 • 19 citations

Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil

1981 • 19 citations

Enhancement of Antigen-Specific Suppression by Muramyl Dipeptide

1983 • 17 citations

Induction of biologically active antibodies by a polyvalent synthetic vaccine constructed without carrier

1987 • 16 citations

Biological Studies of Lipophilic Mdp-Derivatives Incorporated in Liposomes

1981 • 15 citations

Potential use of human interleukin 2 as an adjunct for the therapy of neoplasia, immunodeficiency and infectious disease

1985 • 12 citations

Macrophage activation as an immune correlate to protective immunity against schistosomiasis in mice immunized with an irradiated, cryopreserved live vaccine

1987 • 9 citations

Immunology: Lymphokines and interleukins emerge from the primeval soup

1985 • 5 citations

Biological Response Modifiers

1987 • 4 citations