Protective effects of FTY720 on chronic allograft nephropathy by reducing late lymphocytic infiltration

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

1998 • 586 citations

Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells.

1989 • 481 citations

Chronic allograft nephropathy: An update

1999 • 367 citations

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

1995 • 306 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

A NOVEL IMMUNOSUPPRESSANT, FTY720, WITH A UNIQUE MECHANISM OF ACTION, INDUCES LONG-TERM GRAFT ACCEPTANCE IN RAT AND DOG ALLOTRANSPLANTATION1

1996 • 291 citations

INDIRECT ALLORECOGNITION OF MAJOR HISTOCOMPATIBILITY COMPLEX ALLOPEPTIDES IN HUMAN RENAL TRANSPLANT RECIPIENTS WITH CHRONIC GRAFT DYSFUNCTION1

1997 • 290 citations

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. II. FTY720 Prolongs Skin Allograft Survival by Decreasing T Cell Infiltration into Grafts But Not Cytokine Production In Vivo

1998 • 263 citations

Sequential cytokine dynamics in chronic rejection of rat renal allografts: roles for cytokines RANTES and MCP-1.

1995 • 222 citations

Immunosuppressive agents in organ transplantation: past, present, and future.

2000 • 145 citations

Chronic transplant rejection

1994 • 135 citations

A new immunosuppressant, FTY720, induces bcl‐2‐associated apoptotic cell death in human lymphocytes

1996 • 121 citations

Sex hormones and gender-related differences: Their influence on chronic renal allograft rejection

1999 • 114 citations

Differential Proliferation of Rat Lung Fibroblasts Induced by the Platelet-derived Growth Factor-AA, -AB, and -BB Isoforms Secreted by Rat Alveolar Macrophages

1991 • 103 citations

Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo

2001 • 100 citations

Effect of angiotensin-converting enzyme inhibition on growth factor mRNA in chronic renal allograft rejection in the rat

2000 • 87 citations

SDZ-RAD PREVENTS MANIFESTATION OF CHRONIC REJECTION IN RAT RENAL ALLOGRAFTS

2000 • 85 citations

Immunosuppressant FTY720 Induces Apoptosis by Direct Induction of Permeability Transition and Release of Cytochrome c from Mitochondria

2000 • 85 citations

IL-10 immunosuppression in transplantation

1995 • 79 citations

Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis: an active mode of immune evasion in colon cancer

2001 • 78 citations

Analysis of the mode of action of a novel immunosuppressant FTY720 in mice

1999 • 65 citations

Molecular analyses of human renal allografts: differential intragraft gene expression during rejection.

1997 • 64 citations

The intragraft gene activation of markers reflecting T-cell-activation and -cytotoxicity analyzed by quantitative RT-PCR in renal transplantation.

1996 • 62 citations

Highly Altered Vβ Repertoire of T Cells Infiltrating Long-Term Rejected Kidney Allografts

2000 • 62 citations

RENAL ALLOGRAFT-INFIL TRATING LYMPHOCYTES A PROSPECTIVE ANALYSIS OF IN VITRO GROWTH CHARACTERISTICS AND CLINICAL RELEVANCE

1992 • 53 citations

Prevention of graft rejection and graft-versus-host reaction by a novel immunosuppressant, FTY 720, in rat small bowel transplantation

1997 • 50 citations

Cellular and molecular parameters in human renal allograft rejection

2001 • 44 citations

PROLONGATION OF CANINE LIVER ALLOGRAFT SURVIVAL BY A NOVEL IMMUNOSUPPRESSANT, FTY720

2000 • 44 citations

Infiltration patterns of macrophages and lymphocytes in chronically rejecting rat kidney allografts

1994 • 41 citations

Immunosuppressive therapy using FTY720 combined with tacrolimus in rat liver transplantation

2000 • 39 citations

Infiltration patterns of macrophages and lymphocytes in chronically rejecting rat kidney allografts

1994 • 31 citations

Morphologic features of chronic rejection in kidney and less commonly transplanted organs

1994 • 31 citations

Contribution of androgens to chronic allograft nephropathy is mediated by dihydrotestosterone

2001 • 28 citations

FTY720, a novel immunosuppressant, shows a synergistic effect in combination with FK 506 in rat allograft models

1999 • 28 citations

The significance of timing of FTY720 administration on the immunosuppressive effect to prolong rat skin allograft survival

2000 • 26 citations

FTV 720A mediates reduction of lymphocyte counts in human renal allograft recipients by an apoptosis-independent mechanism

2000 • 23 citations

Apoptosis and expression of cytotoxic T lymphocyte effector molecules in renal allografts

1999 • 23 citations

The Pathophysiology of Chronic Rejection

1997 • 23 citations

FTY 720A mediates reduction of lymphocyte counts in human renal allograft recipients by an apoptosis-independent mechanism

2000 • 23 citations

Combined FTY720/cyclosporine A treatment promotes graft survival and lowers the peripheral lymphocyte count in DA to Lewis heart and skin transplantation models

2001 • 22 citations

Induction of lymphocyte apoptosis in rat liver allograft with ongoing rejection by FTY720

2001 • 21 citations

FTY720, a novel immunosuppressive agent with insulinotropic activity, prolongs graft survival in a mouse islet transplantation model

2001 • 17 citations

IMMUNOBIOLOGY OF RENAL TRANSPLANTATION

1998 • 14 citations

Effect of a Novel Immunosuppressant, FTY720, on Allograft Survival after Renal Transplant in Rats

2000 • 12 citations

Immunosuppressive effect of FTY 720 on rat pancreas allograft

1998 • 12 citations

Host leukocytes and their products in chronic kidney allograft rejection in rats

1994 • 12 citations

Influence of Intrarenal Deposits of Ciclosporin A on Acute Renal Transplant Rejection

1995 • 12 citations

Impact of new immunosuppressive agents on late graft outcome.

1997 • 11 citations

FTY720 blocks allograft rejection by homing of lymphocytes in vivo

2000 • 10 citations

A short-course therapy with FTY720 prolongs allograft survival after canine kidney transplantation

1999 • 9 citations

Long-term Graft Acceptance in Rat Heart Transplantation by CTLA4Ig Gene Transfection Combined with FTY720 Treatment

2001 • 9 citations

INVOLVEMENT OF PLATELET-DERIVED GROWTH FACTOR AND HISTOCOMPATIBILITY OF DRB 1 IN CHRONIC RENAL ALLOGRAFT NEPHROPATHY1

2001 • 8 citations

The Pathophysiology of Chronic Rejection

1997 • 7 citations

Prevention of graft rejection and graft-versus-host reaction by a novel immunosuppressant, FTY720, in rat small bowel transplantation

1997 • 7 citations

Tolerance induction with FTY720 and donor-specific blood transfusion: discrepancy between heart transplantation and intestinal transplantation

2000 • 6 citations

In vivo migration of lymphocytes in chronically rejecting rat kidney allografts

1999 • 5 citations

In vivo migration of lymphocytes in chronically rejecting rat kidney allografts

1999 • 5 citations

Interstitial mononuclear cell infiltrates in chronic rejection of the kidney and correlation with peripheral blood

1996 • 3 citations

T-cell interactions with extracellular matrix proteins and endothelium in chronic renal allograft rejection

1997 • 2 citations

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