Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia‐induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue

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1979 • 13,229 citations

Pathobiology of ischaemic stroke: an integrated view

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1996 • 3,063 citations

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

1986 • 2,584 citations

Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins

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Pathophysiology and treatment of focal cerebral ischemia

1992 • 1,287 citations

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

1986 • 1,257 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

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COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex.

1996 • 597 citations

Negative Regulation of Toll-like Receptor-mediated Signaling by Tollip

2002 • 574 citations

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

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Multiple Molecular Penumbras after Focal Cerebral Ischemia

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Niemann–Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone

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Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia

2001 • 364 citations

Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat

1992 • 309 citations

Characterization of Integrin–Tetraspanin Adhesion Complexes

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ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family

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Regulation of Brain-Derived Neurotrophic Factor Gene Expression after Transient Middle Cerebral Artery Occlusion with and without Brain Damage

1995 • 248 citations

Narp and NP1 Form Heterocomplexes that Function in Developmental and Activity-Dependent Synaptic Plasticity

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Analysis of Dscam Diversity in Regulating Axon Guidance in Drosophila Mushroom Bodies

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CD44 expression identifies astrocyte-restricted precursor cells

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Delayed Secondary Phase of Peri-Infarct Depolarizations after Focal Cerebral Ischemia: Relation to Infarct Growth and Neuroprotection

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Immediate Early Gene Expression in Response to Cerebral Ischemia

1996 • 191 citations

Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization.

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Tamalin, a PDZ Domain-Containing Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine Nucleotide Exchange Factor Cytohesins

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Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia

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Genomics of the Periinfarction Cortex after Focal Cerebral Ischemia

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Hyperthermia complicates middle cerebral artery occlusion induced by an intraluminal filament

1994 • 163 citations

Induction of 27-kDa heat shock protein following cerebral ischemia in a rat model of ischemic tolerance

1994 • 161 citations

Involvement of Multispecific Organic Anion Transporter, Oatp14 (Slc21a14), in the Transport of Thyroxine across the Blood-Brain Barrier

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Insulin Receptor Substrate (IRS)-1 and IRS-2 Are Tyrosine-phosphorylated and Associated with Phosphatidylinositol 3-Kinase in Response to Brain-derived Neurotrophic Factor in Cultured Cerebral Cortical Neurons

1997 • 152 citations

Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro

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Phosphorylation of Signal Transducer and Activator of Transcription-3 (Stat3) after Focal Cerebral Ischemia in Rats

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Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion

2004 • 131 citations

Multiple and surprising new functions for emerin, a nuclear membrane protein

2003 • 126 citations

Parallel Gene Expression Monitoring using Oligonucleotide Probe Arrays of Multiple Transcripts with an Animal Model of Focal Ischemia

2000 • 122 citations

Microvascular Basal Lamina Injury after Experimental Focal Cerebral Ischemia and Reperfusion in the Rat

2002 • 121 citations

A Soluble Fn14-Fc Decoy Receptor Reduces Infarct Volume in a Murine Model of Cerebral Ischemia

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ERp19 and ERp46, New Members of the Thioredoxin Family of Endoplasmic Reticulum Proteins

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ERK Pathway Positively Regulates the Expression of Sprouty Genes

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DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat

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Increased expression of heme oxygenase mRNA in rat brain following transient forebrain ischemia

1994 • 103 citations

Calumenin, a Ca2+-binding Protein Retained in the Endoplasmic Reticulum with a Novel Carboxyl-terminal Sequence, HDEF

1997 • 103 citations

Modulation of synaptic signalling complexes by Homer proteins

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Delta/Notch-like Epidermal Growth Factor (EGF)-related Receptor, a Novel EGF-like Repeat-containing Protein Targeted to Dendrites of Developing and Adult Central Nervous System Neurons

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GRP94 (94 kDa glucose‐regulated protein) suppresses ischemic neuronal cell death against ischemia/reperfusion injury

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Neuronal uptake and metabolism of glycerol and the neuronal expression of mitochondrial glycerol‐3‐phosphate dehydrogenase

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KID-1, a Protein Kinase Induced by Depolarization in Brain

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AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3‐kinase‐dependent activation in extracellular signal‐regulated kinase to upregulate BDNF gene expression

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Transferrin Is an Essential Factor for Myelination

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Regulation of dendritic development by neuronal activity

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Biphasic Expression of the Fos and Jun Families of Transcription Factors Following Transient Forebrain Ischaemia in the Rat. Effect of Hypothermia

1995 • 77 citations

Glial responses, clusterin, and complement in permanent focal cerebral ischemia in the mouse

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Increased Expression of Apolipoprotein D Following Experimental Traumatic Brain Injury

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Transcriptional response to circumscribed cortical brain ischemia: spatiotemporal patterns in ischemic vs. remote non‐ischemic cortex

2004 • 69 citations

N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway

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Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia

1993 • 68 citations

Signaling crosstalk between NF-κB and JNK

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Expression of nonclassical MHC class I (RT1‐U) in certain neuronal populations of the central nervous system

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Antisense suppression of the chloride intracellular channel family induces apoptosis, enhances tumor necrosis factor {alpha}-induced apoptosis, and inhibits tumor growth.

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Stimulated initiation of mitogen-activated protein kinase phosphatase-1 (MKP-1) gene transcription involves the synergistic action of multiple cis-acting elements in the proximal promoter

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DNA array reveals altered gene expression in response to focal cerebral ischemia

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Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures

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The effect of hypothermia on the expression of neurotrophin mRNA in the hippocampus following transient cerebral ischemia in the rat

1998 • 53 citations

Antisense Suppression of the Chloride Intracellular Channel Family Induces Apoptosis, Enhances Tumor Necrosis Factor α-Induced Apoptosis, and Inhibits Tumor Growth

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Vimentin-expressing proximal reactive astrocytes correlate with migration rather than proliferation following focal brain injury

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Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity

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Molecular Mechanisms of Ischemic Brain Damage

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Induction of CL100 Protein Tyrosine Phosphatase following Transient Forebrain Ischemia in the Rat Brain

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Temporal patterns of the embryonic intermediate filaments nestin and vimentin expression in the cerebral cortex of adult rats after cryoinjury

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Temporal and spatial gene expression patterns after experimental stroke in a rat model and characterization of PC4, a potential regulator of transcription

2003 • 42 citations

Phosphorylation of Carboxyl-terminal Tyrosines Modulates the Specificity of Sprouty-2 Inhibition of Different Signaling Pathways

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Activation of Arc gene, a dendritic immediate early gene, by middle cerebral artery occlusion in rat brain

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Localisation of the GPRC5B receptor in the rat brain and spinal cord

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Cystatin-B is expressed by neural stem cells and by differentiated neurons and astrocytes

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Permeability transition in rat liver mitochondria is modulated by the ATP-Mg/P_icarrier

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Induction of NGFI-A mRNA following middle cerebral artery occlusion in rats: In situ hybridization study

1994 • 24 citations

Cerebral activation and distribution of inducible hsp110 and hsp70 mRNAs following focal ischemia in rat

2001 • 21 citations

In situ expression of heat shock proteins, Hsc73, Hsj2 and Hsp86 in the developing tooth germ of mouse lower first molar.

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Identification of oxidative stress‐regulated genes in rat aortic smooth muscle cells by suppression subtractive hybridization

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Increased choline kinase activity in the rat superior cervical ganglion after axonal injury

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Identification of regulated genes during transient cortical ischemia in mice by restriction-mediated differential display (RMDD)

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Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25

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Spatio-temporal heterogeneity and cell-specificity of long-term potentiation-induced mRNA expression in the dentate gyrus in vivo

2002 • 8 citations