Multiple and surprising new functions for emerin, a nuclear membrane protein

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

2003 • 2,054 citations

NPS@: Network Protein Sequence Analysis

2000 • 1,666 citations

Identification of essential genes in cultured mammalian cells using small interfering RNAs

2001 • 835 citations

Nuclear Membrane Proteins with Potential Disease Links Found by Subtractive Proteomics

2003 • 647 citations

Nuclear lamins: building blocks of nuclear architecture

2002 • 574 citations

Life at the edge: the nuclear envelope and human disease

2002 • 426 citations

LMNA mutations in atypical Werner's syndrome

2003 • 424 citations

Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues

2001 • 396 citations

Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF

2001 • 328 citations

Lamins: building blocks or regulators of gene expression?

2002 • 288 citations

Syne-1, A Dystrophin- and Klarsicht-related Protein Associated with Synaptic Nuclei at the Neuromuscular Junction

2000 • 261 citations

Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex

2000 • 257 citations

Nesprin‐1α self‐associates and binds directly to emerin and lamin A in vitro

2002 • 252 citations

BAF is required for emerin assembly into the reforming nuclear envelope

2001 • 240 citations

A Myosin I Isoform in the Nucleus

2000 • 237 citations

Nuclear envelope defects associated withLMNAmutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy

2001 • 228 citations

The nuclear envelope, muscular dystrophy and gene expression

2000 • 227 citations

Transcriptional Repressor Germ Cell-less (GCL) and Barrier to Autointegration Factor (BAF) Compete for Binding to Emerin in Vitro

2003 • 223 citations

Btf, a Novel Death-Promoting Transcriptional Repressor That Interacts with Bcl-2-Related Proteins

1999 • 218 citations

Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA

2001 • 210 citations

Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy

2001 • 208 citations

LAP2 binds to BAFDNA complexes: requirement for the LEM domain and modulation by variable regions

2001 • 205 citations

MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans

2003 • 202 citations

The Nesprins Are Giant Actin-Binding Proteins, Orthologous to Drosophila melanogaster Muscle Protein MSP-300

2002 • 200 citations

The nucleoskeleton: lamins and actin are major players in essential nuclear functions

2003 • 195 citations

Actin in the nucleus: what form and what for?

2002 • 194 citations

Nuclear membrane protein LAP2β mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less)

2001 • 190 citations

Barrier-to-autointegration factor

2002 • 171 citations

Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C

2002 • 155 citations

Dynamic interaction between BAF and emerin revealed by FRAP, FLIP, and FRET analyses in living HeLa cells

2003 • 142 citations

Barrier to Autointegration Factor Interacts with the Cone-Rod Homeobox and Represses Its Transactivation Function

2002 • 125 citations

Expression of Lamin A Mutated in the Carboxyl-Terminal Tail Generates an Aberrant Nuclear Phenotype Similar to That Observed in Cells from Patients with Dunnigan-Type Partial Lipodystrophy and Emery-Dreifuss Muscular Dystrophy

2003 • 102 citations

Emerin interacts in vitro with the splicing‐associated factor, YT521‐B

2003 • 94 citations

Cell Cycle Dynamics of the Nuclear Envelope

2003 • 85 citations

Association of emerin with nuclear and cytoplasmic actin is regulated in differentiating myoblasts

2003 • 84 citations

108th ENMC International Workshop, 3rd Workshop of the MYO-CLUSTER project: EUROMEN, 7th International Emery-Dreifuss Muscular Dystrophy (EDMD) Workshop, 13–15 September 2002, Naarden, The Netherlands

2003 • 84 citations

Nuclear envelope proteins and neuromuscular diseases

2002 • 81 citations

Failure of lamin A/C to functionally assemble in R482L mutated familial partial lipodystrophy fibroblasts: altered intermolecular interaction with emerin and implications for gene transcription

2003 • 80 citations

The expression, lamin-dependent localization and RNAi depletion phenotype for emerin inC. elegans

2002 • 78 citations

Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo

2003 • 74 citations

Structural analysis of emerin, an inner nuclear membrane protein mutated in X‐linked Emery–Dreifuss muscular dystrophy

2001 • 66 citations

Functional consequences of anLMNAmutation associated with a new cardiac and non-cardiac phenotype

2003 • 65 citations

Emerin and cardiomyopathy in Emery–Dreifuss muscular dystrophy1This paper was presented at the 3rd Congress of the World Muscle Society (WMS) in Naples, Italy, May 29–30 1998.1

1999 • 58 citations

The cell cycle dependent mislocalisation of emerin may contribute to the Emery-Dreifuss muscular dystrophy phenotype

2002 • 53 citations

Increased solubility of lamins and redistribution of lamin C in X-linked Emery–Dreifuss muscular dystrophy fibroblasts

2002 • 52 citations

Caspase-mediated cleavage of the chromosome-binding domain of lamina-associated polypeptide 2α

2000 • 48 citations

Effects of expressing lamin A mutant protein causing Emery-Dreifuss muscular dystrophy and familial partial lipodystrophy in Hela cells

2003 • 44 citations

<scp>C</scp>DNA microarray analysis of gene expression in fibroblasts of patients with x‐linked Emery–Dreifuss muscular dystrophy

2002 • 41 citations

Investigation of nuclear architecture with a domain-presenting expression system

2002 • 37 citations

The lamina-associated polypeptide 2 (LAP2) isoforms β, γ andω of zebrafish: developmental expression and behavior during the cell cycle

2003 • 33 citations

Staurosporine treatment and serum starvation promote the cleavage of emerin in cultured mouse myoblasts: involvement of a caspase‐dependent mechanism

2001 • 27 citations

Functional domains of the nucleus: implications for Emery–Dreifuss muscular dystrophy

2002 • 24 citations

Fate of the Nuclear Lamina during Caenorhabditis elegans Apoptosis

2002 • 13 citations