Mixed Agonist–Antagonist Properties of Clozapine at Different Human Cloned Muscarinic Receptor Subtypes Expressed in Chinese Hamster Ovary Cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

Pharmacologic Analysis of Drug Receptor Interaction

1988 • 936 citations

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

1988 • 669 citations

Antischizophrenic Drugs and Brain Cholinergic Receptors

1974 • 474 citations

Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism

1974 • 382 citations

The Effects of Clozapine on Tardive Dyskinesia

1991 • 304 citations

Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cells.

1992 • 271 citations

Clozapine: neuroleptic-induced EPS and tardive dyskinesia

1989 • 256 citations

Clozapine: guidelines for clinical management.

1989 • 230 citations

THE INHIBITION OF THE CONDITIONED RESPONSE AND THE COUNTERACTION OF SCHIZOPHRENIA BY MUSCARINIC STIMULATION OF THE BRAIN

1957 • 191 citations

Pharmacological actions of the atypical antipsychotic drug clozapine: A review

1996 • 181 citations

Clozapine is a potent and selective muscarinic M4 receptor agonist

1994 • 179 citations

Pharmacology characterization of guanine nucleotide exchange reactions in membranes from Cho cells stably transfected with human muscarinic receptors m1–m4

1993 • 121 citations

Muscarinic m4 receptor activation by some atypical antipsychotic drugs

1997 • 93 citations

In vivo actions of clozapine and haloperidol on the turnover rate of acetylcholine in rat striatum.

1976 • 82 citations

Clozapine — A Novel Antipsychotic Agent

1991 • 80 citations

Constitutive activity of the M₁–M₄ subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists

1995 • 73 citations

Effect of anticholinergics on positive and negative symptoms in schizophrenia.

1992 • 65 citations

Extrapyramidal Symptoms during Long-Term Treatment with Antipsychotics Special Focus on Clozapine and D1 and D2 Dopamine Antagonists

1996 • 51 citations

Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor

1997 • 50 citations

Porcine m2 Muscarinic Acetylcholine Receptor-Effector Coupling in Chinese Hamster Ovary Cells

1995 • 46 citations

Peripheral and central muscarinic receptor affinity of psychotropic drugs

1977 • 46 citations

Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine.

1994 • 44 citations

The effects of physostigmine in phenothiazine resistant chronic schizophrenic patients: Preliminary observations

1973 • 36 citations

Antipsychotic-Induced Extrapyramidal Symptoms

1996 • 35 citations

Anti-dopaminergic and anti-muscarinic effects of dibenzodiazepines

1976 • 27 citations

Muscarinic antagonists attenuate the increase in accumbens and striatum dopamine metabolism produced by clozapine but not by haloperidol

1991 • 20 citations

Prevention of physostigmine-induced lethality in rats. A pharmacological analysis.

1982 • 19 citations

Effect of chronic neuroleptic treatment on central and peripheral muscarinic receptors

1993 • 17 citations

Antiacetylcholine activities of psychoactive drugs: a comparison of the [3H]quinuclidinyl benzilate binding assay with conventional methods

1976 • 17 citations

Effects of clozapine in a selective muscarinic bioassay and on single cells of the rat hippocampus

1982 • 9 citations

Atypical antipsychotic drugs

2012 • 3 citations