Involvement of microtubule integrity in memory impairment caused by colchicine

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Observations on the brains of demented old people

1970 • 2,066 citations

The Fine Structure of the Nervous System.

1970 • 1,971 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood

1990 • 1,352 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Neuroactive steroids

1992 • 1,260 citations

Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat

1993 • 1,066 citations

The Fine Structure of the Nervous System

1991 • 1,058 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells

1999 • 1,046 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

1997 • 938 citations

Estrogen Deficiency and Risk of Alzheimer's Disease in Women

1994 • 843 citations

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease

1999 • 777 citations

Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women

1988 • 708 citations

Evolution of the neuropathology of Alzheimer's disease

1996 • 673 citations

Perforant pathway changes and the memory impairment of Alzheimer's disease

1986 • 665 citations

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

1992 • 625 citations

Estradiol increases choline acetyltransferase activity in specific basal forebrain nuclei and projection areas of female rats

1985 • 526 citations

Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly

1998 • 469 citations

Estrogen receptors colocalize with low-affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain.

1992 • 431 citations

Effect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory Tasks

1999 • 431 citations

A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA

1985 • 422 citations

Estrogen improves psychological function in asymptomatic postmenopausal women.

1991 • 404 citations

Estrogen Replacement Therapy and Cognitive Function in Older Women

1993 • 383 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ER and ER Expressed in Chinese Hamster Ovary Cells

1999 • 371 citations

Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.

1994 • 365 citations

Neuritic pathology and dementia in alzheimer's disease

1991 • 362 citations

On the role of hippocampal connections in the performance of place and cue tasks: Comparisons with damage to hippocampus.

1984 • 322 citations

β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

1996 • 305 citations

5′ Splice Site Mutations in tau Associated with the Inherited Dementia FTDP-17 Affect a Stem-Loop Structure That Regulates Alternative Splicing of Exon 10

1999 • 294 citations

Role of Estrogen Replacement Therapy in Memory Enhancement and the Prevention of Neuronal Loss Associated With Alzheimer’s Disease

1997 • 280 citations

Interactions of colchicine with tubulin

1991 • 276 citations

On the role of hippocampal connections in the performance of place and cue tasks: Comparisons with damage to hippocampus.

1984 • 270 citations

On the Genesis of Sexual Differentiation of the Central Nervous System: Morphogenetic Consequences of Steroidal Exposure and Possible Role of α-Fetoprotein

1984 • 263 citations

Cytoplasmic microtubules in tissue culture cells appear to grow from an organizing structure towards the plasma membrane.

1976 • 263 citations

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

1987 • 263 citations

Evaluation of Estrogen Treatment in Female Patients with Dementia of the Alzheimer Type.

1994 • 248 citations

Age‐related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique

1992 • 248 citations

Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer’s Disease

1998 • 241 citations

Estrogen Replacement Therapy and Memory in Older Women

1994 • 230 citations

A Cytoskeletal Mechanism for Ca2+ Channel Metabolic Dependence and Inactivation by Intracellular Ca2+

1993 • 215 citations

The effect of colchicine on the axonal transport of protein in the optic nerve and tract of the rabbit

1969 • 203 citations

Tau Pathology in a Family with Dementia and a P301L Mutation in Tau

1999 • 181 citations

Fine structural localization of acid phosphatase in senile plaques in Alzheimer's presenile dementia

1967 • 163 citations

THE PROGRESSION OF THE PATHOLOGICAL CHANGES OF ALZHEIMER'S DISEASE IN FRONTAL AND TEMPORAL NEOCORTEX EXAMINED BOTH AT BIOPSY AND AT AUTOPSY

1988 • 159 citations

Neurofibrillary Tangles and Alzheimer’s Disease

1998 • 156 citations

92016229 Estrogen improves psychological function in asymptomatic postmenopausal women

1992 • 156 citations

Neurotoxic effects of colchicine: Differential susceptibility of CNS neuronal populations

1982 • 152 citations

Estrogen and Cognitive Functioning in Surgically Menopausal Womena

1990 • 119 citations

Cochicine-induced granule cell loss in rat hippocampus: Selective behavioral and histological alterations

1986 • 118 citations

Dynamics of colchicine effects on rapid axonal transport and axonal morphology

1973 • 101 citations

Microtubule-neurofilament segregation produced by beta, beta'- iminodipropionitrile: evidence for the association of fast axonal transport with microtubules

1983 • 92 citations

Morphometric studies of the aged hippocampus: I. Volumetric analysis in behaviorally characterized rats

1999 • 84 citations

The spatial organization of corneal endothelial cytoskeletal proteins and their relationship to the apical junctional complex.

1995 • 79 citations

Identification and distribution of axonal dystrophic neurites in Alzheimer's disease

1993 • 74 citations

Estrogen replacement therapy and cognitive function in older women

1993 • 72 citations

Microtubule disruption and cognitive defects: Effect of colchicine on learning behavior in rats

1991 • 71 citations

Time-dependent neurobiological effects of colchicine administered directly into the hippocampus of rats

1987 • 54 citations

Colchicine-induced alterations of reference memory in rats: role of spatial versus non-spatial task components

1989 • 53 citations

Structure of the caudal neural tube in an ascidian larva: Vestiges of its possible evolutionary origin from a ciliated band

1992 • 52 citations

Amyloid, dementia and Alzheimer's disease.

1992 • 51 citations

EFFECTS OF COLCHICINE AND VINBLASTINE ON AXONAL TRANSPORT AND TRANSMITTER RELEASE IN SYMPATHETIC NERVES

1975 • 50 citations

Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins

1999 • 46 citations

Axonal microtubules necessary for generation of sodium current in squid giant axons: I. pharmacological study on sodium current and restoration of sodium current by microtubule proteins and 260K protein

1983 • 46 citations

The Cytoskeleton and Neurotransmitter Receptors

1996 • 43 citations

Cytoplasmic microtubules are essential for the formation of membrane-bound polyribosomes.

1985 • 43 citations

Silver impregnation of degenerating dendrites, cells and axons central to axonal transection I. A nauta study on the hypoglossal nerve in kittens

1967 • 42 citations

Gamma-aminobutyric acidA receptor function is inhibited by microtubule depolymerization.

1994 • 40 citations

Effects of chronic intrahippocampal infusion of lipopolysaccharide in the rat

1996 • 39 citations

Potential mechanisms underlying the destruction of dentate gyrus granule cells by colchicine

1982 • 37 citations

Effects of Estrogen Treatment on Sensorimotor Task Performance and Brain Dopamine Concentrations in Gonadectomized Male and Female CD-1 Mice

1994 • 37 citations

Reduction of motor behavioural deficits in senescence via chronic prolactin or estrogen administration: time course and putative mechanisms of action

1989 • 30 citations

Colchicine as an investigative tool in neurobiology

1987 • 28 citations

Ultrastructural abnormalities in the cerebral neocortex and hippocampus associated with Alzheimer's disease and aging

1987 • 28 citations

Role of dentate gyrus cells in retention of a radial arm maze task and sensitivity of rats to cholinergic drugs.

1988 • 24 citations

Role of dentate gyrus cells in retention of a radial arm maze task and sensitivity of rats to cholinergic drugs.

1988 • 23 citations

Long-term behavioral and neurochemical effects of intradentate administration of colchicine in rats.

1991 • 12 citations

Requirement of a colchicine‐sensitive component of the cytoskeleton for acetylcholine receptor recovery

1995 • 9 citations

Acute lymphoblastic leukaemia in rats induces pathomorphological changes in germ cells

2009 • 1 citations