Microtubule disruption and cognitive defects: Effect of colchicine on learning behavior in rats

Statistical principles in experimental design.

1962 • 27,228 citations

Statistical Principles in Experimental Design

1964 • 8,376 citations

Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

1978 • 2,036 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Protein synthesis and memory: A review.

1984 • 1,450 citations

Neuroleptics and operant behavior: The anhedonia hypothesis

1982 • 1,021 citations

DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

1986 • 704 citations

Alzheimer's disease

1982 • 538 citations

Biochemistry of Altered Brain Proteins in Alzheimer's Disease

1989 • 261 citations

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

1989 • 255 citations

Selective memory loss following nucleus basalis lesions: Long term behavioral recovery despite persistent cholinergic deficiencies

1985 • 247 citations

Hypothesis: Interference with Axonal Transport of Neurofilament as a Common Pathogenetic Mechanism in Certain Diseases of the Central Nervous System

1985 • 217 citations

Reach training selectively alters dendritic branching in subpopulations of layer II–III pyramids in rat motor-somatosensory forelimb cortex

1989 • 203 citations

Memory failures in progressive idiopathic dementia.

1981 • 189 citations

Drug Screening and Evaluative Procedures

1962 • 126 citations

Plasticity in the 904-day-old male rat cerebral cortex

1985 • 103 citations

Hypothesis: microtubules, a key to Alzheimer disease.

1989 • 91 citations

Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents

1988 • 81 citations

The progressive ratio schedule as a model for studying the psychomotor stimulant activity of drugs in the rat

1983 • 63 citations

IV. Neurotoxicity of colchicine and other tubulin-binding agents: A selective vulnerability of certain neurons to the disruption of microtubules

1984 • 61 citations

Colchicine lesions in the rat hippocampus mimic the alterations of several markers in Alzheimer's disease

1987 • 61 citations

The Possible Involvement of Brain Microtubules in Memory Fixation

1974 • 58 citations

Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.

1989 • 34 citations

Rat cortical morphology following crowded-enriched living conditions

1987 • 34 citations

Colchicine as an investigative tool in neurobiology

1987 • 28 citations

Chapter 23 Experimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons

1986 • 28 citations

Characteristics of Microtubules at the Different Stages of Neuronal Differentiation and Maturation

1989 • 24 citations

Uptake of [3H]colchicine into brain and liver of mouse, rat, and chick

1981 • 21 citations

Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.

1989 • 21 citations

Interactions of microtubule-active agents with nicotinic acetylcholine receptors. Relationship to their inhibition of catecholamine secretion by adrenal chromaffin cells.

1985 • 18 citations

Philothermal response, microtubules and dementia

1986 • 14 citations

Lymphocyte concanavalin A capping: a similarity between Down's syndrome and early onset primary degenerative dementia.

1986 • 13 citations

Long-term memory: Disruption by inhibitors of protein synthesis and cytoplasmic flow

1981 • 13 citations

The effects of colchicine and vinblastine on memory in chicks

1981 • 8 citations

Cellular Basis of Classical Conditioning Mediated by the Red Nucleus in the Cat

1986 • 7 citations

Comparison of the Effects of Colchicine and Beta-Lumicolchicine on Cultured Adrenal Chromaffin Cells: Lack of Evidence for an Action of Colchicine on Receptor-Associated Microtubules

1987 • 4 citations

Neuronal damage in the albino rat: Excitotoxin, microtubule inhibitor synergism

1988 • 3 citations

Deleted Work

1955 • 0 citations