Structural and dynamic characterization of partially folded states of apomyoglobin and implications for protein folding

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Funnels, pathways, and the energy landscape of protein folding: A synthesis

1995 • 2,607 citations

The 13C Chemical-Shift Index: A simple method for the identification of protein secondary structure using 13C chemical-shift data

1994 • 2,121 citations

Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation

1994 • 2,051 citations

1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

1995 • 1,525 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Navigating the Folding Routes

1995 • 1,193 citations

Empirical correlation between protein backbone conformation and C.alpha. and C.beta. 13C nuclear magnetic resonance chemical shifts

1991 • 1,072 citations

1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects

1995 • 1,013 citations

Correlating backbone amide and side chain resonances in larger proteins by multiple relayed triple resonance NMR

1992 • 1,012 citations

HNCACB, a High-Sensitivity 3D NMR Experiment to Correlate Amide-Proton and Nitrogen Resonances with the Alpha- and Beta-Carbon Resonances in Proteins

1993 • 797 citations

Polypeptide secondary structure determination by nuclear magnetic resonance observation of short proton-proton distances

1984 • 756 citations

Folding of immunogenic peptide fragments of proteins in water solution

1988 • 735 citations

Formation of a Molten Globule Intermediate Early in the Kinetic Folding Pathway of Apomyoglobin

1993 • 735 citations

Structural Characterization of a Partly Folded Apomyoglobin Intermediate

1990 • 708 citations

Amino acid type determination in the sequential assignment procedure of uniformly 13C/15N-enriched proteins

1993 • 692 citations

Three-dimensional triple-resonance NMR Spectroscopy of isotopically enriched proteins

2011 • 561 citations

[27] Circular dichroism and optical rotatory dispersion of proteins and polypeptides

1973 • 547 citations

X-ray structure and refinement of carbon-monoxy (Fe II)-myoglobin at 1.5 Å resolution

1986 • 511 citations

Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig .alpha.-lactalbumin

1989 • 473 citations

Conformation of peptide fragments of proteins in aqueous solution: implications for initiation of protein folding

1988 • 463 citations

Secondary and Tertiary Structural Effects on Protein NMR Chemical Shifts: an ab Initio Approach

1993 • 448 citations

Folding of immunogenic peptide fragments of proteins in water solution

1988 • 437 citations

PATHWAYS OF PROTEIN FOLDING

1993 • 435 citations

Origins of structure in globular proteins.

1990 • 336 citations

An efficient 3D NMR technique for correlating the proton and15N backbone amide resonances with the α-carbon of the preceding residue in uniformly15N/13C enriched proteins

1991 • 330 citations

Direct observation of fast protein folding: the initial collapse of apomyoglobin.

1996 • 317 citations

The nature of protein folding pathways: The classical versus the new view

1995 • 315 citations

Characterizing transition states in protein folding: an essential step in the puzzle

1995 • 308 citations

Thermodynamic study of the apomyoglobin structure

1988 • 299 citations

[11] Multidimensional heteronuclear nuclear magnetic resonance of proteins

1994 • 269 citations

Structure and dynamics of the acid-denatured molten globule state of .alpha.-lactalbumin: a two-dimensional NMR study

1993 • 248 citations

Is Apomyoglobin a Molten Globule? Structural Characterization by NMR

1996 • 245 citations

Three-state analysis of sperm whale apomyoglobin folding

1993 • 226 citations

Structural Characterization of the Molten Globule and Native States of Apomyoglobin by Solution X-ray Scattering

1995 • 222 citations

Probing the conformational state of apomyoglobin by limited proteolysis 1 1Edited by P. E. Wright

1997 • 189 citations

Probing the stability of a partly folded apomyoglobin intermediate by site-directed mutagenesis

1991 • 179 citations

Chemical shift dispersion and secondary structure prediction in unfolded and partly folded proteins

1997 • 156 citations

Packing interactions in the apomyglobin folding intermediate

1996 • 152 citations

Backbone Dynamics of a Highly Disordered 131 Residue Fragment of Staphylococcal Nuclease

1994 • 146 citations

INSIGHTS INTO PROTEIN FOLDING FROM NMR

1996 • 145 citations

Thermodynamic Puzzle of Apomyoglobin Unfolding

1994 • 142 citations

Sequence-Corrected 15N "Random Coil" Chemical Shifts

1994 • 141 citations

The Radius of Gyration of an Apomyoglobin Folding Intermediate

1995 • 139 citations

Cold Denaturation of the Molten Globule States of Apomyoglobin and a Profile for Protein Folding

1994 • 132 citations

Structure and stability of a second molten globule intermediate in the apomyoglobin folding pathway.

1995 • 123 citations

Compactness of protein molten globules: temperature-induced structural changes of the apomyoglobin folding intermediate

1994 • 101 citations

Folding propensities of peptide fragments of myoglobin

1997 • 88 citations

A new triple-resonance experiment for the sequential assignment of backbone resonances in proteins

1995 • 81 citations

tRNA Structure and Ribosomal Function

1994 • 69 citations

Characterization of hydrophobic cores in apomyoglobin: a proton NMR spectroscopy study

1990 • 68 citations

Molten globular characteristics of the native state of apomyoglobin

1994 • 64 citations

High Resolution Crystal Structures of the Deoxy, Oxy, and Aquomet Forms of Cobalt Myoglobin

1996 • 61 citations

Overexpression of myoglobin and assignment of its amide, C? and C? resonances

1995 • 57 citations

Populating the equilibrium molten globule state of apomyoglobin under conditions suitable for structural characterization by NMR

1997 • 57 citations

Detection of residue contacts in a protein folding intermediate

1997 • 52 citations

The native state of apomyoglobin described by proton NMR spectroscopy: The A-B-G-H interface of wild-type sperm whale apomyoglobin

1996 • 49 citations

Comprehensive NOE characterization of a partially folded large fragment of staphylococcal nuclease Δ131Δ, using NMR methods with improved resolution

1997 • 49 citations

Pathways of Protein Folding

1993 • 17 citations