Effects of Green Tea and EGCG on Cardiovascular and Metabolic Health

Summary of the Second Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)

1993 • 28,274 citations

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

2003 • 25,662 citations

Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)

2001 • 24,089 citations

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

2002 • 18,132 citations

Global Prevalence of Diabetes

2004 • 15,420 citations

Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation

1998 • 14,996 citations

Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report

2002 • 12,876 citations

Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)

2002 • 12,292 citations

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Projections of Global Mortality and Burden of Disease from 2002 to 2030

2006 • 10,858 citations

Prevalence of Obesity, Diabetes, and Obesity-Related Health Risk Factors, 2001

2003 • 5,872 citations

Effects on Blood Pressure of Reduced Dietary Sodium and the Dietary Approaches to Stop Hypertension (DASH) Diet

2001 • 5,241 citations

The metabolic syndrome

2005 • 5,005 citations

Banting lecture 1988. Role of insulin resistance in human disease

1988 • 3,751 citations

Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions

2003 • 1,796 citations

Dietary Approaches to Prevent and Treat Hypertension

2006 • 1,276 citations

Mortality and causes of death in the WHO multinational study of vascular disease in diabetes

2001 • 1,235 citations

Metabolic Syndrome and Risk of Cardiovascular Disease: A Meta-Analysis

2006 • 1,167 citations

Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study

2002 • 1,115 citations

The chemistry of tea flavonoids

1997 • 1,109 citations

Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement

2004 • 1,031 citations

Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans

1999 • 929 citations

Mortality in Adults With and Without Diabetes in a National Cohort of the U.S. Population, 1971–1993

1998 • 891 citations

The Burden of Mortality Attributable to Diabetes

2005 • 845 citations

Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study

2006 • 805 citations

Targeting Multiple Signaling Pathways by Green Tea Polyphenol (−)-Epigallocatechin-3-Gallate

2006 • 792 citations

Obesity and Risk of Type 2 Diabetes and Cardiovascular Disease in Children and Adolescents

2003 • 738 citations

Green Tea Consumption and Mortality Due to Cardiovascular Disease, Cancer, and All Causes in Japan

2006 • 736 citations

A NEW PROGNOSTIC CLASSIFICATION OF RECTAL CANCER

1987 • 695 citations

Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate*

2000 • 513 citations

Beneficial effects of tea catechins on diet-induced obesity: stimulation of lipid catabolism in the liver

2002 • 512 citations

Efficacy of Lifestyle Modification for Long‐Term Weight Control

2004 • 503 citations

Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

2004 • 488 citations

Mechanisms of Cancer Prevention by Tea Constituents

2003 • 483 citations

Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men

2005 • 467 citations

The Relationship between Green Tea and Total Caffeine Intake and Risk for Self-Reported Type 2 Diabetes among Japanese Adults

2006 • 446 citations

Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes

2002 • 439 citations

Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation

2005 • 415 citations

Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect

2007 • 399 citations

Effect of EGCG on lipid absorption and plasma lipid levels in rats

2003 • 393 citations

Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea

1999 • 374 citations

A global response to a global problem : the epidemic of overnutrition.

2002 • 373 citations

EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR

2007 • 367 citations

Ethnic Differences in Mortality, End-Stage Complications, and Quality of Care Among Diabetic Patients

2005 • 364 citations

Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (‐)‐epigallocatechin‐3‐gallate: implications for neurodegenerative diseases

2004 • 356 citations

Neutrophil Restraint by Green Tea: Inhibition of Inflammation, Associated Angiogenesis, and Pulmonary Fibrosis

2003 • 332 citations

Body Weight Loss and Weight Maintenance in Relation to Habitual Caffeine Intake and Green Tea Supplementation

2005 • 329 citations

Epigallocatechin Gallate Supplementation Alleviates Diabetes in Rodents

2006 • 328 citations

Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study

2007 • 319 citations

Tea, obesity, and diabetes

2006 • 319 citations

Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration

2005 • 316 citations

Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity

2002 • 310 citations

Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans.

2004 • 308 citations

Differences in Diabetes Prevalence, Incidence, and Mortality Among the Elderly of Four Racial/Ethnic Groups: Whites, Blacks, Hispanics, and Asians

2004 • 299 citations

The effects of physical activity and body mass index on cardiovascular, cancer and all-cause mortality among 47 212 middle-aged Finnish men and women

2005 • 296 citations

Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice.

2004 • 295 citations

A Single Ascending Dose Study of Epigallocatechin Gallate in Healthy Volunteers

2003 • 287 citations

The burden of type 2 diabetes: are we doing enough?

2003 • 264 citations

The Protective Effect of Habitual Tea Consumption on Hypertension

2004 • 259 citations

パーキンソン病におけるレボドーパ(単独またはカルビドーパと併用)とブロモクリプチン

1976 • 252 citations

Antiangiogenic properties of natural polyphenols from red wine and green tea

2005 • 252 citations

Effect of Green Tea Supplementation on Insulin Sensitivity in Sprague−Dawley Rats

2004 • 247 citations

Effects of green tea on weight maintenance after body-weight loss

2004 • 242 citations

Epigallocatechin-Gallate Enhances the Activity of Tetracycline in Staphylococci by Inhibiting Its Efflux from Bacterial Cells

2004 • 242 citations

Green Tea Inhibits Vascular Endothelial Growth Factor (VEGF) Induction in Human Breast Cancer Cells

2002 • 242 citations

Molecular targets of tea polyphenols in the cardiovascular system

2006 • 239 citations

Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea

2001 • 228 citations

Differential Effects of Green Tea–Derived Catechin on Developing Versus Established Atherosclerosis in Apolipoprotein E–Null Mice

2004 • 224 citations

Inhibition of adenovirus infection and adenain by green tea catechins

2003 • 220 citations

Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans

2005 • 218 citations

Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model

2004 • 211 citations

Evaluation of Epigallocatechin Gallate and Related Plant Polyphenols as Inhibitors of the FabG and FabI Reductases of Bacterial Type II Fatty-acid Synthase

2004 • 210 citations

Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice

2004 • 206 citations

Acute EGCG Supplementation Reverses Endothelial Dysfunction in Patients with Coronary Artery Disease

2007 • 205 citations

Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies

2004 • 205 citations

TEAVIGO<sup>TM</sup> (Epigallocatechin Gallate) Supplementation Prevents Obesity in Rodents by Reducing Adipose Tissue Mass

2005 • 204 citations

Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men

2005 • 198 citations

Green Tea Polyphenols and Cancer Chemoprevention: Multiple Mechanisms and Endpoints for Phase II Trials

2004 • 197 citations

Oolong Tea Increases Metabolic Rate and Fat Oxidation in Men

2001 • 196 citations

Anti-hyperglycemic effect of black tea (Camellia sinensis) in rat

1995 • 196 citations

Green Tea Polyphenol Epigallocatechin-3-gallate (EGCG) Differentially Inhibits Interleukin-1β-Induced Expression of Matrix Metalloproteinase-1 and -13 in Human Chondrocytes

2003 • 194 citations

Effect of Increased Tea Consumption on Oxidative DNA Damage among Smokers: A Randomized Controlled Study

2003 • 192 citations

Reduction of Blood Glucose Levels by Tea Catechin

1993 • 185 citations

Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate

2000 • 183 citations

Green, oolong and black tea extracts modulate lipid metabolism in hyperlipidemia rats fed high-sucrose diet

2001 • 182 citations

Epigallocatechin, a Green Tea Polyphenol, Attenuates Myocardial Ischemia Reperfusion Injury in Rats

2004 • 181 citations

Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients

2005 • 168 citations

Randomized Controlled Trial for an Effect of Green Tea Consumption on Insulin Resistance and Inflammation Markers

2005 • 167 citations

Functional beta cell regeneration in the islets of pancreas in alloxan induced diabetic rats by (−)-epicatechin

1982 • 162 citations

Therapeutic Potential of (-)-Epigallocatechin 3-O-Gallate on Renal Damage in Diabetic Nephropathy Model Rats

2006 • 162 citations

Antihyperglycemic Effect of Oolong Tea in Type 2 Diabetes

2003 • 160 citations

Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer

2006 • 160 citations

Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine

2005 • 159 citations

Relationship among Habitual Tea Consumption, Percent Body Fat, and Body Fat Distribution

2003 • 158 citations

Molecular targets for the cancer preventive activity of tea polyphenols

2006 • 156 citations

Simultaneous determination of twelve tea catechins by high-performance liquid chromatography with electrochemical detection

2001 • 152 citations

Long-term effectiveness of weight-loss interventions in adults with pre-diabetes

2004 • 149 citations

Polyphenolic antioxidant (–)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent

2002 • 146 citations

Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats

2006 • 142 citations

Relation between Green Tea Consumption and the Severity of Coronary Atherosclerosis among Japanese Men and Women

2000 • 139 citations

Protective Effects of Epicatechin Against the Toxic Effects of Streptozotocin on Rat Pancreatic Islets: In Vivo and in Vitro

2003 • 139 citations

Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females

2005 • 137 citations

Paradoxical Effects of Green Tea (Camellia Sinensis) and Antioxidant Vitamins in Diabetic Rats

2005 • 137 citations

Epigallocathechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways

2006 • 135 citations

Mainstreaming the metabolic syndrome: a definitive definition

2005 • 129 citations

Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice

2003 • 127 citations

Effect of Green Tea Consumption on Endothelial Function and Circulating Endothelial Progenitor Cells in Chronic Smokers

2006 • 126 citations

Green tea reduces body fat accretion caused by high-fat diet in rats through β-adrenoceptor activation of thermogenesis in brown adipose tissue

2003 • 125 citations

From walkability to active living potential

2005 • 123 citations

Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro

2001 • 118 citations

Effect of a Thermogenic Beverage on 24‐Hour Energy Metabolism in Humans

2007 • 117 citations

Prevalence and Risks of Undiagnosed Diabetes Mellitus in Patients Undergoing Coronary Artery Bypass Grafting

2005 • 117 citations

Anti-Invasive Effects of Green Tea Polyphenol EpiGalloCatechin-3-Gallate (EGCG), a Natural Inhibitor of Metallo and Serine Proteases

2002 • 112 citations

Reduction in Predicted Coronary Heart Disease Risk After Substantial Weight Reduction After Bariatric Surgery

2006 • 112 citations

Associations between overall physical activity level and cardiovascular risk factors in an adult population

2007 • 108 citations

Relation of Chronic and Acute Glycemic Control on Mortality in Acute Myocardial Infarction With Diabetes Mellitus

2005 • 105 citations

Anti‐obesity actions of green tea: Possible involvements in modulation of the glucose uptake system and suppression of the adipogenesis‐related transcription factors

2004 • 105 citations

Black and Green Teas Equally Inhibit Diabetic Cataracts in a Streptozotocin-Induced Rat Model of Diabetes

2005 • 98 citations

Relationship between obesity and the increased risk of major complications in non‐insulin‐dependent diabetes mellitus

1998 • 96 citations

Effects of (-)-epicatechin, a flavonoid on lipid peroxidation and antioxidants in streptozotocin-induced diabetic liver, kidney and heart.

2005 • 95 citations

Effect of tea catechins on postprandial plasma lipid responses in human subjects

2005 • 94 citations

Powdered green tea has antilipogenic effect on Zucker rats fed a high‐fat diet

2003 • 89 citations

Anti-obesity Effects of Tea Catechins in Humans.

2001 • 86 citations

Oolong tea increases plasma adiponectin levels and low-density lipoprotein particle size in patients with coronary artery disease

2004 • 82 citations

Green tea leaf extract improves lipid and glucose homeostasis in a fructose-fed insulin-resistant hamster model

2005 • 81 citations

Oolong tea increases energy metabolism in Japanese females.

2003 • 80 citations

EFFECTS OF (‐)‐EPIGALLOCATECHIN‐3‐O‐GALLATE (GREEN TEA TANNIN) ON THE LIFE SPAN OF STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

1995 • 77 citations

Catechins inhibit angiotensin II-induced vascular smooth muscle cell proliferation via mitogen-activated protein kinase pathway

2006 • 68 citations

Conformational preferences of 1,4,7-trithiacyclononane: a molecular mechanics and density functional theory study

2004 • 67 citations

Green tea attenuates diabetes induced Maillard-type fluorescence and collagen cross-linking in the heart of streptozotocin diabetic rats

2007 • 63 citations

Green tea impedes dyslipidemia, lipid peroxidation, protein glycation and ameliorates Ca2+-ATPase and Na+/K+-ATPase activity in the heart of streptozotocin-diabetic rats

2006 • 62 citations

Effect of Green Tea and Black Tea on the Blood Glucose, the Blood Triglycerides, and Antioxidation in Aged Rats

1998 • 62 citations

GREEN TEA EXTRACT IMPEDES DYSLIPIDAEMIA AND DEVELOPMENT OF CARDIAC DYSFUNCTION IN STREPTOZOTOCIN‐DIABETIC RATS

2006 • 61 citations

The prophylactic action of (−)-Epicatechin against alloxan induced diabetes in rats

1981 • 59 citations

Dieting is more effective in reducing weight but exercise is more effective in reducing fat during the early phase of a weight-reducing program in healthy humans

2003 • 56 citations

Prevalence of undiagnosed Type 2 diabetes and impaired fasting glucose in older B ritish men and women

2005 • 55 citations

THERAPEUTIC EFFECT OF GREEN TEA EXTRACT ON ADVANCED GLYCATION AND CROSS‐LINKING OF COLLAGEN IN THE AORTA OF STREPTOZOTOCIN DIABETIC RATS

2006 • 46 citations

Effects of (−)-epigallocatechin-3-gallate on pancreatic beta-cell damage in streptozotocin-induced diabetic rats

2006 • 42 citations

Reporting of diabetes on death certificates using data from the UK Prospective Diabetes Study

2005 • 42 citations

Effect of green tea on angiogenesis and severity of atherosclerosis in cholesterol-fed rabbit

2006 • 39 citations

Preventive effects of green tea catechins on spontaneous stroke in rats.

2007 • 35 citations

Positive inotropic effect of purified green tea catechin derivative in guinea pig hearts: The measurements of cellular Ca2+ and nitric oxide release

2006 • 33 citations

Habitual green tea consumption and risk of an aneurysmal rupture subarachnoid hemorrhage: A case–control study in Nagoya, Japan

2006 • 27 citations

Alloxan-induced diabetes in the rat - protective action of (-) epicatechin?

1984 • 27 citations

Assessment of the antidiabetic activity of epicatechin in streptozotocin-diabetic and spontaneously diabetic BB/E rats

1985 • 26 citations

Moderate Changes in Weight and Physical Activity Can Prevent or Delay the Development of Type 2 Diabetes Mellitus in Susceptible Individuals

2003 • 23 citations

Dose-Dependent Suppression of Tea Catechins with a Galloyl Moiety on Postprandial Hypertriglyceridemia in Rats

2005 • 20 citations

The lack of effectiveness of (−)-epicatechin against alloxan induced diabetes in Wistar rats

1983 • 20 citations

Effects of Green Tea Catechin on Polymorphonuclear Leukocyte 5′-Lipoxygenase Activity, Leukotriene B<sub>4</sub> Synthesis, and Renal Damage in Diabetic Rats

2004 • 17 citations