Role for TNF in atherosclerosis? Lessons from autoimmune disease

Aortic Stiffness Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Patients

2001 • 3,767 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Cytokines in the pathogenesis of rheumatoid arthritis

2007 • 2,377 citations

Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial

1999 • 2,358 citations

A Comparison of Etanercept and Methotrexate in Patients with Early Rheumatoid Arthritis

2000 • 1,757 citations

Adalimumab, a fully human anti–tumor necrosis factor α monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: The ARMADA trial

2003 • 1,750 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure

2003 • 1,504 citations

Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta‐analysis of observational studies

2008 • 1,354 citations

Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial

2008 • 1,347 citations

High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors

2001 • 1,296 citations

Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?

2001 • 1,237 citations

Targeted Anticytokine Therapy in Patients With Chronic Heart Failure

2004 • 1,148 citations

INHIBITORY EFFECT OF TNF$alpha; ANTIBODIES ON SYNOVIAL CELL INTERLEUKIN-1 PRODUCTION IN RHEUMATOID ARTHRITIS

1989 • 1,137 citations

Arterial Stiffness, Wave Reflections, and the Risk of Coronary Artery Disease

2003 • 1,073 citations

High incidence of cardiovascular events in a rheumatoid arthritis cohort not explained by traditional cardiac risk factors

2001 • 1,040 citations

JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice

2005 • 1,035 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

Rheumatoid Arthritis

1996 • 960 citations

Inflammatory Mediators and the Failing Heart

2002 • 938 citations

Explaining How “High-Grade” Systemic Inflammation Accelerates Vascular Risk in Rheumatoid Arthritis

2003 • 922 citations

Accelerated atherosclerosis: An extraarticular feature of rheumatoid arthritis?

2002 • 616 citations

Role of TNF-α in vascular dysfunction

2009 • 605 citations

Anti–Tumor Necrosis Factor-α Treatment Improves Endothelial Function in Patients With Rheumatoid Arthritis

2002 • 578 citations

Tumor Necrosis Factor-α in Sera of Obese Patients: Fall with Weight Loss

1998 • 543 citations

Reduction in the incidence of myocardial infarction in patients with rheumatoid arthritis who respond to anti–tumor necrosis factor α therapy: Results from the British Society for Rheumatology Biologics Register

2007 • 542 citations

Treatment with tumor necrosis factor blockers is associated with a lower incidence of first cardiovascular events in patients with rheumatoid arthritis.

2005 • 532 citations

The Th17/Treg imbalance in patients with acute coronary syndrome

2008 • 474 citations

The risk of congestive heart failure in rheumatoid arthritis: A population‐based study over 46 years

2005 • 456 citations

Case Reports of Heart Failure after Therapy with a Tumor Necrosis Factor Antagonist

2003 • 450 citations

Cardiovascular morbidity and mortality in patients with seropositive rheumatoid arthritis in Northern Sweden.

1997 • 429 citations

Rheumatoid Arthritis Is Associated With Increased Aortic Pulse-Wave Velocity, Which Is Reduced by Anti–Tumor Necrosis Factor-α Therapy

2006 • 407 citations

JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes

2005 • 396 citations

Pulse-Wave Analysis

2002 • 374 citations

HLA–DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis

2007 • 351 citations

Interpreting lipid levels in the context of high-grade inflammatory states with a focus on rheumatoid arthritis: a challenge to conventional cardiovascular risk actions

2009 • 280 citations

Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis

2004 • 249 citations

High prevalence of subclinical atherosclerosis in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors

2007 • 243 citations

Influence of anti-tumour necrosis factor therapy on cardiovascular risk factors in patients with active rheumatoid arthritis

2004 • 225 citations

Endothelial dysfunction in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors

2007 • 206 citations

Does tumor necrosis factor α inhibition promote or prevent heart failure in patients with rheumatoid arthritis?

2008 • 193 citations

Increased prevalence of atherosclerosis in patients with medium term rheumatoid arthritis.

2001 • 170 citations

Infliximab Improves Endothelial Dysfunction in Systemic Vasculitis

2004 • 167 citations

Atherosclerotic disease is increased in recent-onset rheumatoid arthritis: a critical role for inflammation

2007 • 158 citations

Response to anti-tumour necrosis factor alpha blockade is associated with reduction of carotid intima-media thickness in patients with active rheumatoid arthritis

2007 • 155 citations

Modulation of lipoprotein plasma concentrations during long-term anti-TNF therapy in patients with active rheumatoid arthritis

2007 • 154 citations

Atorvastatin reduces arterial stiffness in patients with rheumatoid arthritis

2004 • 136 citations

Short term effects of infliximab on the lipid profile in patients with rheumatoid arthritis.

2005 • 130 citations

Anti-inflammatory therapy with tumour necrosis factor alpha inhibitors improves high-density lipoprotein cholesterol antioxidative capacity in rheumatoid arthritis patients

2008 • 121 citations

Endothelial dysfunction in young patients with long-term rheumatoid arthritis and low disease activity

2003 • 115 citations

Effects of tumor necrosis factor blockade on cardiovascular risk factors in psoriatic arthritis: A double‐blind, placebo‐controlled study

2007 • 112 citations

Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis

2008 • 106 citations

Influence of anti-TNF-alpha infliximab therapy on adhesion molecules associated with atherogenesis in patients with rheumatoid arthritis.

2006 • 103 citations

Changes in lipid profile during infliximab and corticosteroid treatment in rheumatoid arthritis

2007 • 101 citations

Endothelial progenitor cells in active rheumatoid arthritis: effects of tumour necrosis factor and glucocorticoid therapy

2007 • 100 citations

Serum lipids and disease severity in children with severe meningococcal sepsis*

2005 • 100 citations

Effect of anti TNFalpha therapy on arterial diameter and wall shear stress and HDL cholesterol

2004 • 99 citations

Short‐term improvement of endothelial function in rituximab‐treated rheumatoid arthritis patients refractory to tumor necrosis factor α blocker therapy

2008 • 97 citations

Effect of anti–tumor necrosis factor α therapy on the progression of subclinical atherosclerosis in severe rheumatoid arthritis

2006 • 97 citations

Tumour necrosis factor antagonists improve disease activity but not arterial stiffness in rheumatoid arthritis

2005 • 88 citations

Human neutrophil peptides: a novel potential mediator of inflammatory cardiovascular diseases

2008 • 79 citations

Hyperlipidaemia, statin use and the risk of developing rheumatoid arthritis

2008 • 72 citations

Effects of repeated infliximab therapy on serum lipid profile in patients with refractory rheumatoid arthritis

2005 • 71 citations

Circulating concentrations of insulin markers and coronary heart disease: a quantitative review of 19 Western prospective studies

2007 • 70 citations

Prevalence of the antiphospholipid syndrome in primary systemic vasculitis

2005 • 69 citations

Postsurgical reduction of serum lipoproteins: Interleukin-6 and the acute-phase response

1998 • 68 citations

Changes in serum lipids and lipoproteins in cancer patients during chemotherapy

1992 • 64 citations

Increased augmentation index in rheumatoid arthritis and its relationship to coronary artery atherosclerosis.

2007 • 59 citations

Effect of tumor necrosis factor α on cholesterol efflux in adipocytes

2007 • 42 citations

Dyslipoproteinaemia in patients with active, chronic polyarthritis. a study on serum lipoproteins and triglyceride clearance (intravenous fat tolerance test)

1977 • 39 citations

"5D" Outcome in 52 patients with rheumatoid arthritis surviving 20 years after initial disease modifying antirheumatic drug therapy.

2002 • 10 citations

Rates of Myocardial Infarction (MI) and Cerebrovascular Accident (CVA) are reduced in patients with Rheumatoid Arthritis (RA) treated with anti-TNF therapy compared to those treated with traditional DMARDS: Results from the BSR biologics register

2006 • 7 citations