Functional IL-4 receptors on mouse astrocytes: IL-4 inhibits astrocyte activation and induces NGF secretion

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

Molecular profile of reactive astrocytes—Implications for their role in neurologic disease

1993 • 1,436 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

1985 • 855 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.

1982 • 754 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms

1989 • 645 citations

Synthesis of nitric oxide in CNS glial cells

1993 • 627 citations

Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages^*

1988 • 511 citations

Induction of Nitric Oxide Synthase in Glial Cells

1992 • 501 citations

IL-4 down-regulates IL-1 and TNF gene expression in human monocytes.

1989 • 421 citations

The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response

1988 • 351 citations

Induction and regulation of interleukin-6 gene expression in rat astrocytes

1990 • 314 citations

Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells.

1988 • 244 citations

Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors

1993 • 244 citations

Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells.

1987 • 237 citations

A possible novel pathway of regulation by murine T helper type‐2 (T_h2) cells of a T_h1 cell activity via the modulation of the induction of nitric oxide synthase on macrophages

1991 • 226 citations

Multiple sclerosis patients express increased levels of β-nerve growth factor in cerebrospinal fluid

1992 • 221 citations

Neuroprotective role of IL-4 against activated microglia.

1993 • 214 citations

Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines

1992 • 207 citations

Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1

1992 • 201 citations

B-cell stimulatory factor 1 activates resting B cells.

1985 • 201 citations

Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis.

1994 • 188 citations

Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction.

1991 • 175 citations

Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells.

1993 • 168 citations

Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.

1992 • 163 citations

Expression of cytokine receptors in cultured neuronal and glial cells

1993 • 161 citations

Recombinant soluble murine IL-4 receptor can inhibit or enhance IgE responses in vivo.

1993 • 142 citations

Differential regulation of astrocyte TNF‐α expression by the cytokines TGF‐β, IL‐6 and IL‐10

1995 • 132 citations

Intracerebral cytokine mRNA expression during fatal and nonfatal alphavirus encephalitis suggests a predominant type 2 T cell response.

1994 • 132 citations

Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-α, interleukin-1β, and interferon-γ in astrocytes

1994 • 129 citations

Expression of high-affinity IL-4 receptors on human melanoma, ovarian and breast carcinoma cells

1994 • 127 citations

Cytokines Regulate L‐Arginine‐Dependent Cyclic GMP Production in Rat Glial Cells

1993 • 124 citations

Interactions of the nervous and immune systems in development, normal brain homeostasis, and disease ¹

1995 • 121 citations

Cytokine network in the central nervous system and its roles in growth and differentiation of glial and neuronal cells

1995 • 117 citations

Interleukin-4 is a potent mitogen for capillary endothelium

1991 • 100 citations

Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression

1994 • 93 citations

Differential regulation by cytokines of human astrocyte nitric oxide production

1995 • 89 citations

Nerve growth factor increases in adult rat brain after hypoxic injury

1989 • 83 citations

Interleukin‐4 and ‐5 as modulators of nerve growth factor synthesis/secretion in astrocytes

1993 • 77 citations

Differential effects of Th1 and Th2 derived cytokines on NGF synthesis by mouse astrocytes

1996 • 76 citations

B cell stimulatory factor 1 (IL-4) enhances the development of cytotoxic T cells from Lyt-2+ resting murine T lymphocytes.

1988 • 71 citations

Astrocytes and intracerebral immune responses

1989 • 70 citations

Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2.

1983 • 68 citations

Activated mouse astrocytes and T cells express similar CD44 variants. Role of CD44 in astrocyte/T cell binding

1993 • 67 citations

Augmentation of major histocompatibility complex class I and ICAM‐1 expression on glial cells following measles virus infection: Evidence for the role of type‐1 interferon

1992 • 53 citations

Seizure-Induced Increases in NGF mRNA Exhibit Different Time Courses across Forebrain Regions and Are Biphasic in Hippocampus

1994 • 53 citations

Human astrocyte growth regulation: interleukin-4 sensitivity and receptor expression

1995 • 39 citations

Staurosporine Induces Astrocytic Phenotypes and Differential Expression of Specific PKC Isoforms in C6 Glial Cells

1995 • 33 citations

Rat astrocytes express interferon-γ immunoreactivity in normal optic nerve and after nerve transection

1990 • 32 citations

Platelet activating factor induces nerve growth factor production by rat astrocytes

1995 • 30 citations

Interleukin-4 down-regulates adult human astrocyte DNA synthesis and proliferation.

1993 • 30 citations

Interleukin-4 modulates the proliferation and differentiation of glial cells

1994 • 26 citations

Astrocyte activation by Sindbis virus: Expression of GFAP, cytokines, and adhesion molecules

1997 • 24 citations

Astrocyte activation by Sindbis virus: Expression of GFAP, cytokines, and adhesion molecules

1997 • 23 citations

Modulation of Proliferation and Antigen Expression of a Cloned Human Glioblastoma by Interleukin-4 Alone and in Combination with Tumor Necrosis Factor-α and/or Interferon-γ

1993 • 21 citations

Local cytokine responses during acute and chronic viral infections of the central nervous system

1994 • 16 citations

Interleukin-4 down-regulates MHC class II antigens on cultured rat astrocytes

1996 • 14 citations

Interleukin 4

1992 • 6 citations