Effects of conformationally restricted synthetic retinoids on ovarian tumor cell growth

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Apoptosis by Death Factor

1997 • 5,038 citations

The RXR heterodimers and orphan receptors

1995 • 3,168 citations

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

1992 • 1,790 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

1992 • 1,252 citations

Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?

1995 • 1,011 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Cellular Biology and Biochemistry of the Retinoids

1984 • 730 citations

The retinoid receptors.

1994 • 665 citations

HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

1990 • 390 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Retinoic Acid Receptor β Mediates the Growth-Inhibitory Effect of Retinoic Acid by Promoting Apoptosis in Human Breast Cancer Cells

1996 • 337 citations

A new class of retinoids with selective inhibition of AP-1 inhibits proliferation

1994 • 318 citations

THE ROLES OF RETINOIDS IN VERTEBRATE DEVELOPMENT

1995 • 280 citations

Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells.

1994 • 249 citations

Activation of Retinoid X Receptors Induces Apoptosis in HL-60 Cell Lines

1995 • 247 citations

Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ

1992 • 205 citations

p53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.

1995 • 197 citations

Synergistic Activation of Retinoic Acid (RA)-Responsive Genes and Induction of Embryonal Carcinoma Cell Differentiation by an RA Receptor α (RARα)-, RARβ-, or RARγ-Selective Ligand in Combination with a Retinoid X Receptor-Specific Ligand

1995 • 180 citations

Regulation of apoptosis induced by the retinoid N-(4-hydroxyphenyl) retinamide and effect of deregulated bcl-2

1995 • 146 citations

An ELISA for detection of apoptosis

1997 • 127 citations

Regulation of human ornithine decarboxylase expression by the c-Myc.Max protein complex.

1993 • 126 citations

Induction of apoptosis by fenretinide (4HPR) in human ovarian carcinoma cells and its association with retinoic acid receptor expression

1996 • 121 citations

Evidence for the Involvement of Retinoic Acid Receptor RARα-dependent Signaling Pathway in the Induction of Tissue Transglutaminase and Apoptosis by Retinoids

1995 • 120 citations

Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-alpha acquire sensitivity to growth inhibition by retinoids.

1994 • 109 citations

Identification of retinoids with nuclear receptor subtype-selective activities.

1991 • 105 citations

Growth Inhibition and Induction of Apoptosis by Fenretinide in Small-Cell Lung Cancer Cell Lines

1995 • 103 citations

Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.

1995 • 101 citations

A new sensitive bioassay for precise quantification of interferon activity as measured via the mitochondrial dehydrogenase function in cells (MTT‐method)

1990 • 86 citations

Conformational Effects on Retinoid Receptor Selectivity. 2. Effects of Retinoid Bridging Group on Retinoid X Receptor Activity and Selectivity

1995 • 81 citations

Enhanced efficacy of combinations of retinoic acid- and retinoid X receptor-selective retinoids and alpha-interferon in inhibition of cervical carcinoma cell proliferation.

1995 • 81 citations

Correlation of retinoid binding affinity to retinoic acid receptor alpha with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells.

1995 • 80 citations

Retinoic acid receptor α1 isoform is induced by estradiol and confers retinoic acid sensitivity in human breast cancer cells

1995 • 61 citations

All-trans-Retinoic Acid Blocks Cell Cycle Progression of Human Ovarian Adenocarcinoma Cells at Late G1

1997 • 56 citations

Effect of structural modifications in the C7-C11 region of the retinoid skeleton on biological activity in a series of aromatic retinoids

1989 • 52 citations

Effects of receptor class- and subtype-selective retinoids and an apoptosis-inducing retinoid on the adherent growth of the NIH:OVCAR-3 ovarian cancer cell line in culture

1997 • 46 citations

The effects of dimethyl sulfoxide and retinoic acid on the cell growth and the phenotype of ovarian cancer cells

1991 • 43 citations

Retinoids and Cancer: A Basis for Differentiation Therapy

1993 • 40 citations

Retinoid X receptor-specific retinoids inhibit the ability of retinoic acid receptor-specific retinoids to increase the level of insulin-like growth factor binding protein-3 in human ectocervical epithelial cells.

1996 • 38 citations

Reduction of both RAR and RXR Levels Is Required to Maximally Alter Sensitivity of CA-OV3 Ovarian Tumor Cells to Growth Suppression by all-trans-Retinoic Acid☆

1997 • 35 citations

Retinoic acid receptors in retinoid responsive ovarian cancer cell lines detected by polymerase chain reaction following reverse transcription

1993 • 33 citations

Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition.

1996 • 30 citations

Retinoids—“Differentiation Agents” for Cancer Treatment and Prevention

1992 • 21 citations

Retinoids in the Management of Head and Neck Cancer. An Update

1994 • 12 citations