Akt is a major angiogenic mediator downstream of the Ang1/Tie2 signaling pathway

Cellular survival: a play in three Akts

1999 • 4,229 citations

Vascular-specific growth factors and blood vessel formation

2000 • 3,667 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning

1996 • 1,969 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.

2000 • 1,427 citations

Role of Akt Signaling in Vascular Homeostasis and Angiogenesis

2002 • 981 citations

Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

2002 • 846 citations

Tie2 Receptor Ligands, Angiopoietin-1 and Angiopoietin-2, Modulate VEGF-Induced Postnatal Neovascularization

1998 • 680 citations

Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway

2000 • 633 citations

Akt Mediates Cytoprotection of Endothelial Cells by Vascular Endothelial Growth Factor in an Anchorage-dependent Manner

1999 • 557 citations

Angiopoietin-1 induces sprouting angiogenesis in vitro

1998 • 467 citations

Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

1999 • 463 citations

Vascular Endothelial Growth Factor–Stimulated Actin Reorganization and Migration of Endothelial Cells Is Regulated via the Serine/Threonine Kinase Akt

2000 • 413 citations

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

1998 • 376 citations

VEGF Prevents Apoptosis of Human Microvascular Endothelial Cells via Opposing Effects on MAPK/ERK and SAPK/JNK Signaling

1999 • 374 citations

Marked Induction of the IAP Family Antiapoptotic Proteins Survivin and XIAP by VEGF in Vascular Endothelial Cells

1999 • 342 citations

Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy.

2001 • 335 citations

Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors

2003 • 311 citations

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.

1997 • 257 citations

Angiopoietin-1 Induces Endothelial Cell Sprouting Through the Activation of Focal Adhesion Kinase and Plasmin Secretion

2000 • 249 citations

The Angiopoietins: Yin and Yang in Angiogenesis

1999 • 203 citations

Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.

1998 • 201 citations

Hypoxic Regulation of Angiopoietin-2 Expression in Endothelial Cells

2004 • 196 citations

Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase.

1999 • 191 citations

Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis

2000 • 187 citations

Oxidized LDL Regulates Vascular Endothelial Growth Factor Expression in Human Macrophages and Endothelial Cells Through Activation of Peroxisome Proliferator–Activated Receptor-γ

2001 • 157 citations

Kinases: positive and negative regulators of apoptosis

2000 • 141 citations

Morphogenesis of the First Blood Vessels

1998 • 138 citations

Role of PI 3-Kinase in Angiopoietin-1-Mediated Migration and Attachment-Dependent Survival of Endothelial Cells

1999 • 135 citations

Angiopoietin 2 stimulates migration and tube-like structure formation of murine brain capillary endothelial cells through c-Fes and c-Fyn

2002 • 131 citations

Dominant Negative Forms of Akt (Protein Kinase B) and Atypical Protein Kinase Cλ Do Not Prevent Insulin Inhibition of Phosphoenolpyruvate Carboxykinase Gene Transcription

1999 • 101 citations

Angiopoietin-1 Inhibits Irradiation- and Mannitol-Induced Apoptosis in Endothelial Cells

2000 • 92 citations

Detection of Vascular Endothelial Growth Factor (VEGF) Protein in Vascular and Non-Vascular Cells of the Normal and Oxygen-Injured Rat Retina

1997 • 83 citations

Infectious Angiogenesis

2003 • 71 citations

Receptor tyrosine kinase signaling in vascular development.

1997 • 36 citations

Profound effects on vascular development caused by perturbations during organogenesis.

1997 • 15 citations

Nutritional Regulation of White Adipocyte Vascular Endothelial Growth Factor (VEGF)

2003 • 8 citations