The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Rhodopsin content in the outer segment membranes of bovine and frog retinal rods

1974 • 730 citations

A taxol-dependent procedure for the isolation of microtubules and microtubule-associated proteins (MAPs).

1982 • 553 citations

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

1992 • 531 citations

Protein kinases that phosphorylate activated G protein‐coupled receptors

1995 • 520 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C

1996 • 246 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

Construction of mutant and chimeric genes using the polymerase chain reaction

1989 • 224 citations

Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase

1991 • 220 citations

Internal Trafficking and Surface Mobility of a Functionally Intact β₂-Adrenergic Receptor-Green Fluorescent Protein Conjugate

1997 • 220 citations

Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration

1995 • 213 citations

Mammalian .beta.2-adrenergic receptor: purification and characterization

1984 • 207 citations

Activation by G protein beta gamma subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin.

1992 • 202 citations

Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases

1997 • 184 citations

The kinetics of microtubule assembly. Evidence for a two-stage nucleation mechanism.

1984 • 179 citations

Localization of A-kinase through anchoring proteins.

1994 • 164 citations

Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.

1986 • 154 citations

Interaction cloning of protein kinase C substrates.

1993 • 122 citations

Tubulin phosphorylation by casein kinase II is similar to that found in vivo.

1987 • 116 citations

G Protein-coupled Receptor Kinase GRK2 Is a Phospholipid-dependent Enzyme That Can Be Conditionally Activated by G Protein βγ Subunits

1996 • 111 citations

Interaction of protein kinase C with RACKI, a receptor for activated C-kinase: a role in β protein kinase C mediated signal transduction

1995 • 107 citations

Differential binding of the regulatory subunits (RII) of cAMP-dependent protein kinase II from bovine brain and muscle to RII-binding proteins.

1986 • 102 citations

Phosphorylation of a neuronal-specific beta-tubulin isotype.

1990 • 98 citations

Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.

1996 • 95 citations

Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system.

1993 • 88 citations

Members of the G Protein-Coupled Receptor Kinase Family That Phosphorylate the β₂-Adrenergic Receptor Facilitate Sequestration

1996 • 88 citations

Mechanism of beta-adrenergic receptor kinase activation by G proteins

1993 • 83 citations

Protein Kinase C Domains Involved in Interactions with Other Proteins

1994 • 82 citations

Phosphorylation of β_III-Tubulin

1996 • 72 citations

Tubulin structure and biochemistry

1992 • 71 citations

Immunofluorescent anti-tubulin staining of spindles during meiotic maturation of mouse oocytes in vitro

1978 • 70 citations

Phosphorylation of tubulin enhances its interaction with membranes

1986 • 56 citations

Structure and Function in the Tubulin Dimer and the Role of the Acidic Carboxyl Terminus

1995 • 54 citations

Association of Calcium/Calmodulin‐Dependent Kinase with Cytoskeletal Preparations: Phosphorylation of Tubulin, Neurofilament, and Microtubule‐Associated Proteinsa

1986 • 53 citations

Coordinate depression of bradykinin receptor recycling and microtubule-dependent transport by taxol.

1994 • 43 citations

Cytoskeletal constraint of the beta-adrenergic receptor in frog erythrocyte membranes.

1980 • 42 citations

Correlation between protein kinase C binding proteins and substrates in REF52 cells.

1994 • 34 citations

Involvement of microtubules in the isoproterenol-induced ‘down’-regulation of myocardial β-adrenergic receptors

1983 • 30 citations

Cyclic nucleotide- and Ca2+-independent phosphorylation of tubulin and microtubule-associated protein-2 by glycogen synthase (casein) kinase-1

1984 • 28 citations

A Casein Kinase‐Like Kinase Phosphorylates β‐Tubulin and May Be a Microtubule‐Associated Protein

1992 • 28 citations

Phosphorylation of Tubulin by Casein Kinase II Regulates Its Binding to a Neuronal Protein (NP185) Associated with Brain Coated Vesicles

1989 • 22 citations

Down-regulation of genes encoding DNA replication proteins during cell cycle exit.

1994 • 16 citations

Direct insertion and fluorescence studies of rhodamine-labeled β-adrenergic receptors in cell membranes

1985 • 11 citations

Microtubules and tubulin sheet polymers elongate from isolated axonemes in vitro as observed by negative-stain electron microscopy

1991 • 7 citations