Two RNAi Complexes, RITS and RDRC, Physically Interact and Localize to Noncoding Centromeric RNAs

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Role for a bidentate ribonuclease in the initiation step of RNA interference

2001 • 4,804 citations

RNA interference

2002 • 3,369 citations

RNA interference is mediated by 21- and 22-nucleotide RNAs

2001 • 3,271 citations

A generic protein purification method for protein complex characterization and proteome exploration

1999 • 2,699 citations

RNAi

2000 • 2,596 citations

RNA silencing in plants

2004 • 2,393 citations

Heterologous modules for efficient and versatile PCR-based gene targeting inSchizosaccharomyces pombe

1998 • 2,230 citations

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

2002 • 2,052 citations

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

2002 • 2,040 citations

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

2004 • 1,887 citations

Three new dominant drug resistance cassettes for gene disruption inSaccharomyces cerevisiae

1999 • 1,793 citations

Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi

2001 • 1,492 citations

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

2004 • 1,406 citations

On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing

2001 • 1,282 citations

RNAi-Mediated Targeting of Heterochromatin by the RITS Complex

2004 • 1,219 citations

Unlocking the potential of the human genome with RNA interference

2004 • 1,066 citations

An RNA-Dependent RNA Polymerase Gene in Arabidopsis Is Required for Posttranscriptional Gene Silencing Mediated by a Transgene but Not by a Virus

2000 • 1,061 citations

ARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation

2003 • 1,041 citations

Revealing the world of RNA interference

2004 • 972 citations

Establishment and Maintenance of a Heterochromatin Domain

2002 • 895 citations

Heterochromatic Silencing and HP1 Localization in Drosophila Are Dependent on the RNAi Machinery

2004 • 663 citations

Analysis of a piwi-Related Gene Implicates Small RNAs in Genome Rearrangement in Tetrahymena

2002 • 594 citations

Small RNAs Correspond to Centromere Heterochromatic Repeats

2002 • 501 citations

Dicer is essential for formation of the heterochromatin structure in vertebrate cells

2004 • 484 citations

Structure and conserved RNA binding of the PAZ domain

2003 • 468 citations

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

2003 • 442 citations

Functional Anatomy of a dsRNA Trigger

2000 • 397 citations

RITS acts in cis to promote RNA interference–mediated transcriptional and post-transcriptional silencing

2004 • 395 citations

SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis

2001 • 365 citations

Ancient Pathways Programmed by Small RNAs

2002 • 364 citations

Hairpin RNAs and Retrotransposon LTRs Effect RNAi and Chromatin-Based Gene Silencing

2003 • 314 citations

The Genetics of RNA Silencing

2002 • 300 citations

Isolation of an RNA-Directed RNA Polymerase–Specific cDNA Clone from Tomato

1998 • 251 citations

Genetic analysis of RNA-mediated transcriptional gene silencing

2003 • 236 citations

Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing

2003 • 233 citations

RNA-based silencing strategies in plants

2001 • 212 citations

A chromodomain protein, Chp1, is required for the establishment of heterochromatin in fission yeast

2004 • 200 citations

Gene structure and function of the 2′-5′-oligoadenylate synthetase family

2000 • 199 citations

Cellular RNA-Dependent RNA Polymerase Involved in Posttranscriptional Gene Silencing Has Two Distinct Activity Modes

2002 • 191 citations

cis-Acting DNA from Fission Yeast Centromeres Mediates Histone H3 Methylation and Recruitment of Silencing Factors and Cohesin to an Ectopic Site

2002 • 174 citations

Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex

2004 • 154 citations

Initiation of viral RNA-dependent RNA polymerization

2004 • 151 citations

A Link Between RNA Interference and Nonsense-Mediated Decay in Caenorhabditis elegans

2000 • 145 citations

A single Argonaute protein mediates both transcriptional and posttranscriptional silencing in Schizosaccharomyces pombe

2004 • 141 citations

Cid13 Is a Cytoplasmic Poly(A) Polymerase that Regulates Ribonucleotide Reductase mRNA

2002 • 132 citations

Elongator Interactions with Nascent mRNA Revealed by RNA Immunoprecipitation

2004 • 131 citations

Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest

2002 • 103 citations

Distinct roles of two Yth1p domains in 3′-end cleavage and polyadenylation of yeast pre-mRNAs

2000 • 78 citations

The RITS Complex—A Direct Link between Small RNA and Heterochromatin

2004 • 49 citations

The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha- tubulin

1998 • 40 citations

Primer-independent RNA sequencing with bacteriophage φ6 RNA polymerase and chain terminators

2001 • 26 citations

Deleted Work

1955 • 0 citations