Expression of urokinase plasminogen activator and the urokinase plasminogen activator receptor in myeloma cells

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process

1998 • 761 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells

1977 • 686 citations

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

1997 • 664 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

Bone Marrow Neovascularization, Plasma Cell Angiogenic Potential, and Matrix Metalloproteinase-2 Secretion Parallel Progression of Human Multiple Myeloma

1999 • 590 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

1993 • 437 citations

Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.

1993 • 379 citations

Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient.

1970 • 375 citations

Molecular cloning and sequence analysis of the cDNA for a human serine protease reponsible for activation of hepatocyte growth factor. Structural similarity of the protease precursor to blood coagulation factor XII

1993 • 373 citations

Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction

1995 • 248 citations

uPA, uPAR, PAI-I: Key intersection of proteolytic, adhesive and chemotacfic highways?

1997 • 246 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane

1982 • 226 citations

Hepatocyte growth factor and its receptor c-met in multiple myeloma

1996 • 222 citations

Bone Marrow Neovascularization, Plasma Cell Angiogenic Potential, and Matrix Metalloproteinase-2 Secretion Parallel Progression of Human Multiple Myeloma

1999 • 221 citations

Destruction of extracellular matrices containing glycoproteins, elastin, and collagen by metastatic human tumor cells.

1980 • 221 citations

Human monocytic cells contain high levels of intracellular Fas ligand: rapid release following cellular activation.

1997 • 203 citations

Metalloproteinases in Multiple Myeloma: Production of Matrix Metalloproteinase-9 (MMP-9), Activation of proMMP-2, and Induction of MMP-1 by Myeloma Cells

1997 • 186 citations

Plasminogen activator dependent pathways inthe dissemination of human tumor cells in the chick embryo

1988 • 181 citations

Molecular evolution and domain structure of plasminogen‐related growth factors (HGF/SF and HGF1/MSP)

1994 • 175 citations

Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B.

1992 • 168 citations

Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures

1994 • 166 citations

Rat mammary carcinoma cells secrete active collagenase and activate latent enzyme in the stroma via plasminogen activator

1981 • 149 citations

Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex.

1992 • 141 citations

Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells

1993 • 141 citations

The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils

1994 • 140 citations

Urokinase-type plasminogen activation in three human breast cancer cell lines correlates with their in vitro invasiveness

1996 • 124 citations

Hepatocyte Growth Factor (HGF) Induces Interleukin-11 Secretion From Osteoblasts: A Possible Role for HGF in Myeloma-Associated Osteolytic Bone Disease

1999 • 118 citations

Protein Structure and Membrane Anchorage of the Cellular Receptor for Urokinase-Type Plasminogen Activator

1991 • 117 citations

Urokinase-Type Plasminogen Activator Binding to Its Receptor Stimulates Tumor Cell Migration by Enhancing Integrin-Mediated Signal Transduction

1999 • 112 citations

Cytokine, cytokine receptors, transduction signals, and oncogenes in human multiple myeloma.

1995 • 103 citations

Expression of the Receptor for Urokinasetype Plasminogen Activator in Normal and Neoplastic Blood Cells and Hematopoietic Tissue

1994 • 102 citations

Overexpression of urokinase receptor in breast cancer cells results in increased tumor invasion, growth and metastasis

1996 • 95 citations

The Role of the Plasminogen System in Bone Resorption In Vitro

1999 • 91 citations

TNF and IL‐6 are potent growth factors for OH‐2, a novel human myeloma cell line

1994 • 80 citations

Two subsets of peripheral blood plasma cells defined by differential expression of CD45 antigen

1997 • 76 citations

Induction of CD45 Expression and Proliferation in U-266 Myeloma Cell Line by Interleukin-6

1998 • 65 citations

Involvement of the plasmin system in dissociation of the insulin-like growth factor-binding protein complex

1992 • 64 citations

The Labelling Index of Primitive Plasma Cells Determines the Clinical Behaviour of Patients with Myelomatosis

1996 • 61 citations

Two new IgA1-kappa plasma cell leukaemia cell lines (JJN-1 & JJN-2) which proliferate in response to B cell stimulatory factor 2.

1989 • 60 citations

Expression and functional role of urokinase‐type plasminogen activator receptor in normal and acute leukaemic cells

1998 • 56 citations

Regulation of proteolytic activity in human bone marrow stromal cells by basic fibroblast growth factor, interleukin-1, and transforming growth factor beta

1992 • 45 citations

Detection of vitronectin in mineralized bone matrix.

1996 • 40 citations

Distinct Patterns of Urokinase Receptor (uPAR) Expression by Leukemic Cells and Peripheral Blood Cells

1996 • 38 citations

Cell line derived from patient with myeloma.

1968 • 38 citations

Regulation of the production of plasminogen activators by bone resorption enhancing and inhibiting factors in three types of osteoblast-like cells

1991 • 36 citations

Regulation of the uPAR/uPA system expressed on monocytes by the deactivating cytokines, IL‐4, IL‐10 and IL‐13: consequences on cell adhesion to vitronectin and fibrinogen

1998 • 21 citations

Metalloproteinases in Multiple Myeloma: Production of Matrix Metalloproteinase-9 (MMP-9), Activation of proMMP-2, and Induction of MMP-1 by Myeloma Cells

1997 • 21 citations

Spectrometric Determination of Urokinase in Urine after Gel Filtration, Using the Chromogenic Substrate S-2444

1980 • 12 citations