TNF and IL‐6 are potent growth factors for OH‐2, a novel human myeloma cell line

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Genomic sequencing.

1984 • 8,343 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes

1986 • 1,282 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.

1968 • 833 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

1990 • 678 citations

TUMOUR NECROSIS FACTOR AS AN AUTOCRINE TUMOUR GROWTH FACTOR FOR CHRONIC B-CELL MALIGNANCIES

1988 • 282 citations

Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma

1989 • 271 citations

Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor.

1990 • 263 citations

Response patterns of purified myeloma cells to hematopoietic growth factors

1989 • 231 citations

Serum-free in vitro bioassay for the detection of tumor necrosis factor

1986 • 195 citations

Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266

1991 • 177 citations

Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma.

1989 • 163 citations

Production of cytokines by bone marrow cells obtained from patients with multiple myeloma

1989 • 156 citations

Diagnosis of Nasopharyngeal Carcinoma by DNA Amplification of Tissue Obtained by Fine-Needle Aspiration

1992 • 143 citations

Selective expression of CD45 isoforms defines CALLA+ monoclonal B- lineage cells in peripheral blood from myeloma patients as late stage B cells

1991 • 129 citations

Establishment of two interleukin 6 (B cell stimulatory factor 2/interferon beta 2)-dependent human bone marrow-derived myeloma cell lines.

1989 • 107 citations

Delineation of a novel pre-B cell component in plasma cell myeloma: immunochemical, immunophenotypic, genotypic, cytologic, cell culture, and kinetic features

1987 • 105 citations

In vivo interleukin 6 gene expression in the tumoral environment in multiple myeloma

1991 • 91 citations

Delineation of a novel pre-B cell component in plasma cell myeloma: immunochemical, immunophenotypic, genotypic, cytologic, cell culture, and kinetic features

1987 • 85 citations

Role of interleukin-6 in the proliferation of human multiple myeloma cell lines OCI-My 1 to 7 established from patients with advanced stage of the disease

1991 • 85 citations

Interleukin-6 inhibits the proliferation of B-chronic lymphocytic leukemia cells that is induced by tumor necrosis factor-alpha or -beta

1993 • 77 citations

Lack of IL‐1 secretion from human myeloma cells highly purified by immunomagnetic separation

1993 • 64 citations

Two new IgA1-kappa plasma cell leukaemia cell lines (JJN-1 & JJN-2) which proliferate in response to B cell stimulatory factor 2.

1989 • 60 citations

Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma

1988 • 59 citations

Direct cloning of specific genomic DNA sequences in plasmid libraries following fragment enrichment

1985 • 59 citations

p55 and p75 tumor necrosis factor receptors in patients with chronic lymphocytic leukemia

1992 • 54 citations

A rapid and sensitive immunoassay for tumor necrosis factor using magnetic monodisperse polymer particles

1990 • 52 citations

Heterogeneity in response to interleukin 6 (IL-6), expression of IL-6 and IL-6 receptor mRNA in a panel of established human multiple myeloma cell lines.

1991 • 48 citations

Spontaneous secretion of tumor necrosis factor-beta by human myeloma cell lines

1989 • 42 citations

Autocrine Growth by Two Cytokines, Interleukin-6 and Tumor Necrosis Factor Alpha, in the Myeloma Cell Line KHM-1A

1990 • 31 citations

Establishment and characterization of four myeloma cell lines which are responsive to interleukin-6 for their growth.

1991 • 27 citations

Tumor necrosis factor and interleukin 1 can act as essential growth factors in a murine plasmacytoma line.

1988 • 21 citations

Human tumour necrosis factors-α and -β: Differences in their structure, expression and biological properties

1990 • 18 citations

Establishment and characterization of a plasma cell leukaemia cell line dependent for growth on IL‐6 and a bi‐phenotypic subclone dependent upon both IL‐3 and IL‐6

1991 • 8 citations