Molecular mechanisms regulating the myofilament response to Ca2+: Implications of mutations causal for familial hypertrophic cardiomyopathy

Structure of the actin-myosin complex and its implications for muscle contraction

1993 • 1,756 citations

A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation

1990 • 1,332 citations

Substructure of the myosin molecule

1971 • 1,062 citations

α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere

1994 • 1,008 citations

Mutations in the Genes for Cardiac Troponin T and α-Tropomyosin in Hypertrophic Cardiomyopathy

1995 • 913 citations

Characteristics and Prognostic Implications of Myosin Missense Mutations in Familial Hypertrophic Cardiomyopathy

1992 • 732 citations

Tropomyosin coiled-coil interactions: Evidence for an unstaggered structure

1975 • 670 citations

Developmental and functional adaptation of contractile proteins in cardiac and skeletal muscles

1986 • 657 citations

The troponin complex and regulation of muscle contraction

1995 • 564 citations

Causes of sudden death in competitive athletes

1986 • 531 citations

Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

1987 • 529 citations

Mapping a Gene for Familial Hypertrophic Cardiomyopathy to Chromosome 14q1

1989 • 526 citations

Sports-related and non-sports-related sudden cardiac death in young adults

1991 • 365 citations

Ca2+-induced tropomyosin movement in Limulus thin filaments revealed by three-dimensional reconstruction

1994 • 331 citations

Tropomyosin crystal structure and muscle regulation

1986 • 324 citations

Cardiac Troponin I Phosphorylation Increases the Rate of Cardiac Muscle Relaxation

1995 • 314 citations

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene

1985 • 314 citations

The effect of phosphate and calcium on force generation in glycerinated rabbit skeletal muscle fibers. A steady-state and transient kinetic study

1990 • 300 citations

Troponin, tripomyosin, and actin interactions in the Ca²⁺ion regulation of muscle contraction

1974 • 299 citations

Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy.

1994 • 289 citations

Tropomyosin: Crystal structure, polymorphism and molecular interactions

1969 • 281 citations

Structure of co-crystals of tropomyosin and troponin

1987 • 242 citations

Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy.

1993 • 239 citations

Patterns of inheritance in hypertrophic cardiomyopathy: Assessment by m-mode and two-dimensional echocardiography

1984 • 233 citations

Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in the beta-myosin heavy chain gene. A 908Leu----Val mutation and a 403Arg----Gln mutation.

1992 • 232 citations

Genotype-phenotype correlations in hypertrophic cardiomyopathy. Insights provided by comparisons of kindreds with distinct and identical beta-myosin heavy chain gene mutations.

1994 • 223 citations

OPTICAL ROTATION AND HELICAL POLYPEPTIDE CHAIN CONFIGURATION IN α-PROTEINS

1957 • 222 citations

A molecular basis for familial hypertrophic cardiomyopathy: An αβ cardiac myosin heavy chain hybrid gene

1990 • 221 citations

Recent Advances in the Molecular Genetics of Hypertrophic Cardiomyopathy

1995 • 218 citations

Missense mutations in the beta-myosin heavy-chain gene cause central core disease in hypertrophic cardiomyopathy.

1993 • 203 citations

Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction.

1994 • 202 citations

Tropomyosin: Amino Acid Sequence and Coiled-Coil Structure

1973 • 197 citations

A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3

1993 • 191 citations

Mapping of a novel gene for familial hypertrophic cardiomyopathy to chromosome 11

1993 • 186 citations

Structural interpretation of the two-site binding of troponin on the muscle thin filament

1981 • 185 citations

A comparison of the amino acid sequences of rabbit skeletal muscle alpha- and beta-tropomyosins.

1980 • 185 citations

Troponin and its interactions with tropomyosin

1982 • 184 citations

A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2.

1993 • 177 citations

Ca2+ regulation of mechanical properties of striated muscle. Mechanistic studies using extraction and replacement of regulatory proteins.

1992 • 176 citations

The regulatory switch of the muscle thin filament: Ca2+ or myosin heads?

1994 • 173 citations

A Direct Regulatory Role for Troponin T and a Dual Role for Troponin C in the Ca2+ Regulation of Muscle Contraction

1995 • 169 citations

Molecular Arrangement of Troponin-T in the Thin Filament1

1979 • 167 citations

Analysis of the primary sequence of α-tropomyosin from rabbit skeletal muscle

1975 • 166 citations

Amino-Acid Sequence of Rabbit Skeletal Tropomyosin and Its Coiled-Coil Structure

1972 • 165 citations

Isolation and functional comparison of bovine cardiac troponin T isoforms.

1987 • 164 citations

Binding of troponin-T fragments to several types of tropomyosin. Sensitivity to Ca2+ in the presence of troponin-C.

1982 • 161 citations

A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene

1984 • 157 citations

Familial hypertrophic cardiomyopathy is a genetically heterogeneous disease.

1990 • 153 citations

Molecular and Physiological Effects of Overexpressing Striated Muscle β-Tropomyosin in the Adult Murine Heart

1995 • 150 citations

Complete nucleotide sequence of the fast skeletal troponin T gene

1986 • 146 citations

Altered Interactions Among Thin Filament Proteins Modulate Cardiac Function,

1996 • 134 citations

Calcium-Induced Movement of Troponin-I Relative to Actin in Skeletal Muscle Thin Filaments

1990 • 131 citations

The effects of troponin T fragments T1 and T2 on the binding of nonpolymerizable tropomyosin to F-actin in the presence and absence of troponin I and troponin C.

1987 • 129 citations

Drosophila melanogaster troponin-T mutations engender three distinct syndromes of myofibrillar abnormalities

1990 • 118 citations

Effects of troponin-I plus-C on the binding of troponin-T and its fragments to alpha-tropomyosin. Ca2+ sensitivity and cooperativity.

1983 • 117 citations

Co-operative blocks in tropomyosin

1982 • 115 citations

Sequence repeats in α-tropomyosin

1975 • 114 citations

Regulation of Muscle Contraction: Binding of Troponin and Its Components to Actin and Tropomyosin

1975 • 107 citations

The amino terminus of muscle tropomyosin is a major determinant for function.

1990 • 104 citations

Amino-acid sequence of tropomyosin-binding component of rabbit skeletal muscle troponin.

1976 • 101 citations

Isolation and Characterization of cDNA Clones Encoding Embryonic and Adult Isoforms of Rat Cardiac Troponin T

1989 • 96 citations

Molecular cloning of human cardiac troponin T isoforms: Expression in developing and failing heart

1995 • 92 citations

Non-polymerizable tropomyosin: Preparation, some properties and F-actin binding

1981 • 91 citations

Motions of tropomyosin. Crystal as metaphor

1980 • 90 citations

Troponin-tropomyosin interactions. Fluorescence studies of the binding of troponin, troponin T and chymotryptic troponin T fragments to specifically labeled tropomyosin

1984 • 90 citations

Fragments of rabbit striated muscle alpha-tropomyosin. I. Preparation and characterization.

1981 • 89 citations

Inheritance of hypertrophic cardiomyopathy: a cross sectional and M mode echocardiographic study of 50 families.

1987 • 86 citations

Exchange of β- for α-Tropomyosin in Hearts of Transgenic Mice Induces Changes in Thin Filament Response to Ca2+, Strong Cross-bridge Binding, and Protein Phosphorylation

1996 • 85 citations

Detection of a new mutation in the beta-myosin heavy chain gene in an individual with hypertrophic cardiomyopathy.

1992 • 85 citations

Novel missense mutation in α-tropomyosin gene found in Japanese patients with hypertrophic cardiomyopathy

1995 • 83 citations

Expression of a Mutation Causing Hypertrophic Cardiomyopathy Disrupts Sarcomere Assembly in Adult Feline Cardiac Myocytes

1995 • 83 citations

Localization of gene for familial hypertrophic cardiomyopathy to chromosome 14q1 in a diverse US population.

1991 • 82 citations

Tropomyosin Crystal Dynamics

1972 • 79 citations

Removal of Tropomyosin Overlap Modifies Cooperative Binding of Myosin S-1 to Reconstituted Thin Filaments of Rabbit Striated Muscle

1989 • 76 citations

Troponin T fragments: Physical properties and binding to troponin C

1978 • 75 citations

The binding site of rabbit skeletal α-tropomyosin on troponin-T

1977 • 74 citations

Structure-function studies of the amino-terminal region of bovine cardiac troponin T.

1988 • 71 citations

Fragments of rabbit striated muscle alpha-tropomyosin. II. Binding to troponin-T.

1981 • 66 citations

Deletion of the first 45 NH2-terminal residues of rabbit skeletal troponin T strengthens binding of troponin to immobilized tropomyosin

1991 • 64 citations

Identification of a second binding region on rabbit skeletal troponin‐T for α‐tropomyosin

1981 • 64 citations

Evidence of genetic heterogeneity in five kindreds with familial hypertrophic cardiomyopathy.

1992 • 62 citations

Photochemical cross-linking between rabbit skeletal troponin and alpha-tropomyosin. Attachment of the photoaffinity probe N-(4-azidobenzoyl-[2-3H]glycyl)-S-(2-thiopyridyl)-cysteine to cysteine 190 of alpha-tropomyosin.

1982 • 61 citations

Two-site attachment of troponin to pyrene-labeled tropomyosin.

1991 • 60 citations

Interaction of tropomyosin and troponin T: a proton nuclear magnetic resonance study

1986 • 60 citations

The interaction of rabbit skeletal muscle troponin-T fragments with troponin-I

1985 • 59 citations

Independent origin of identical beta cardiac myosin heavy-chain mutations in hypertrophic cardiomyopathy.

1993 • 58 citations

A comparative study of skeletal and cardiac tropomyosins

1976 • 54 citations

Local structural changes in tropomyosin detected by a trypsin-probe method

1984 • 54 citations

Effects of the amino-terminal regions of tropomyosin and troponin T on thin filament assembly.

1992 • 53 citations

A new missense mutation, Arg719Gln, in the β-cardiac heavy chain myosin gene of patients with familial hypertrophic cardiomyopathy

1994 • 51 citations

Prevalence of Hypertrophic Cardiomyopathy and Limitations of Screening Methods

1995 • 49 citations

Study of the structure of troponin-C by measuring the relative reactivities of lysines with acetic anhydride

1981 • 49 citations

Some properties of cardiac troponin T structure

1983 • 48 citations

Novel missense mutation in cardiac β myosin heavy chain gene found in a japanese patient with hypertrophic cardiomyopathy

1992 • 46 citations

Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy.

1994 • 41 citations

The binding sites of rabbit skeletal troponin-I on troponin-T

1980 • 40 citations

Photochemical cross-linking between rabbit skeletal troponin subunits. Troponin I-troponin T interactions.

1982 • 40 citations

Study of the structure of troponin-T by measuring the relative reactivities of lysines with acetic anhydride

1981 • 40 citations

Two genetically expressed troponin T fragments representing alpha and beta isoforms exhibit functional differences

1992 • 39 citations

Primary structure of rabbit skeletal muscle troponin-T. Purification of cyanogen bromide fragments and the amino acid sequence of fragment CB2.

1977 • 35 citations

Comparison of the structure of two cardiac troponin T isoforms

1985 • 34 citations

Motions of Tropomyosin

1986 • 32 citations

Interaction of rabbit skeletal muscle troponin-T and F-actin at physiological ionic strength

1988 • 29 citations

Effects of deletion of tropomyosin overlap on regulated actomyosin subfragment 1 ATPase

1989 • 27 citations

Identification of a mutation in the beta cardiac myosin heavy chain gene in a family with hypertrophic cardiomyopathy.

1993 • 26 citations

Molecular and Clinical Aspects of Inherited Cardiomyopathies

1995 • 23 citations

Analysis of the amino acid sequence of a tropomyosin-binding fragment from troponin-T

1981 • 21 citations

Movement of tropomyosin during regulation of vertebrate skeletal muscle: A simple physical model

1976 • 21 citations

Primary Structure of Chymotryptic Subfragments from Rabbit Skeletal Troponin T1

1981 • 14 citations

Conformational Change of Troponin T Induced by Calcium Binding to Troponin C

1985 • 5 citations

Location of troponin I‐binding on troponin T sequence

1982 • 5 citations