Genotype-phenotype correlations in hypertrophic cardiomyopathy. Insights provided by comparisons of kindreds with distinct and identical beta-myosin heavy chain gene mutations.

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation

1990 • 1,332 citations

Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

1981 • 910 citations

Hypertrophic Cardiomyopathy

1987 • 907 citations

Enhanced Detection of Ischemic but Viable Myocardium by the Reinjection of Thallium after Stress-Redistribution Imaging

1990 • 801 citations

Intramural (“small vessel”) coronary artery disease in hypertrophic cardiomyopathy

1986 • 740 citations

Characteristics and Prognostic Implications of Myosin Missense Mutations in Familial Hypertrophic Cardiomyopathy

1992 • 732 citations

Prognosis in hypertrophic cardiomyopathy: Role of age and clinical, electrocardiographic and hemodynamic features

1981 • 631 citations

Patterns and significance of distribution of left ventricular hypertrophy in hypertrophic cardiomyopathy

1981 • 611 citations

Causes of sudden death in competitive athletes

1986 • 531 citations

Mapping a Gene for Familial Hypertrophic Cardiomyopathy to Chromosome 14q1

1989 • 526 citations

Prognostic significance of 24 hour ambulatory electrocardiographic monitoring in patients with hypertrophic cardiomyopathy: A prospective study

1981 • 491 citations

Arrhythmia in hypertrophic cardiomyopathy. I: Influence on prognosis.

1981 • 417 citations

Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy.

1981 • 401 citations

Myocardial ischemia detected by thallium scintigraphy is frequently related to cardiac arrest and syncope in young patients with hypertrophic cardiomyopathy

1993 • 276 citations

Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy.

1993 • 239 citations

“Malignant” hypertrophic cardiomyopathy: Identification of a subgroup of families with unusually frequent premature death

1978 • 213 citations

Hypertrophic cardiomyopathy: an important cause of sudden death.

1984 • 204 citations

Missense mutations in the beta-myosin heavy-chain gene cause central core disease in hypertrophic cardiomyopathy.

1993 • 203 citations

Utility of continuous wave doppler echocardiography in the noninvasive assessment of left ventricular outflow tract pressure gradient in patients with hypertrophic cardiomyopathy

1992 • 197 citations

A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3

1993 • 191 citations

Mapping of a novel gene for familial hypertrophic cardiomyopathy to chromosome 11

1993 • 186 citations

Preclinical Diagnosis of Familial Hypertrophic Cardiomyopathy by Genetic Analysis of Blood Lymphocytes

1991 • 186 citations

A familial hypertrophic cardiomyopathy locus maps to chromosome 15q2.

1993 • 177 citations

Hypertrophic cardiomyopathy without hypertrophy: two families with myocardial disarray in the absence of increased myocardial mass.

1990 • 166 citations

Familial hypertrophic cardiomyopathy is a genetically heterogeneous disease.

1990 • 153 citations

Complete sequence and organization of the human cardiac β-myosin heavy chain gene

1990 • 131 citations

Affinity generation of single-stranded DNA for dideoxy sequencing following the polymerase chain reaction

1989 • 113 citations

Detection of a new mutation in the beta-myosin heavy chain gene in an individual with hypertrophic cardiomyopathy.

1992 • 85 citations

Hemodynamic and electrophysiologic evaluation of patients with hypertrophic cardiomyopathy surviving cardiac arrest

1991 • 58 citations

Novel missense mutation in cardiac β myosin heavy chain gene found in a japanese patient with hypertrophic cardiomyopathy

1992 • 46 citations

Identification of a mutation in the beta cardiac myosin heavy chain gene in a family with hypertrophic cardiomyopathy.

1993 • 26 citations

Genetic evidence of dissociation (generational skips) of electrical from morphologic forms of hypertrophic cardiomyopathy

1990 • 23 citations

Ischemia, Coronary Blood Flow, and Coronary Reserve in Hypertrophic Cardiomyopathy

1990 • 7 citations

Left Ventricular Diastolic Function and Myocardial Ischemia in Hypertrophic Cardiomyopathy: Assessment by Radionuclide Methods

1990 • 2 citations