Molecular and Physiological Effects of Overexpressing Striated Muscle β-Tropomyosin in the Adult Murine Heart

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

A molecular basis for familial hypertrophic cardiomyopathy: A β cardiac myosin heavy chain gene missense mutation

1990 • 1,332 citations

α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere

1994 • 1,008 citations

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

1988 • 877 citations

Electrophoretic analysis of multiple forms of rat cardiac myosin: Effects of hypophysectomy and thyroxine replacement

1978 • 772 citations

Enhanced Myocardial Function in Transgenic Mice Overexpressing the β ₂ -Adrenergic Receptor

1994 • 745 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 696 citations

Developmental and functional adaptation of contractile proteins in cardiac and skeletal muscles

1986 • 657 citations

All Members of the MHC Multigene Family Respond to Thyroid Hormone in a Highly Tissue-Specific Manner

1986 • 632 citations

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.

1984 • 609 citations

Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

1987 • 529 citations

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 • 479 citations

The molecular basis for tropomyosin isoform diversity

1991 • 350 citations

Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature.

1985 • 293 citations

Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy.

1994 • 289 citations

Myosin isoenzymes in normal and hypertrophied human ventricular myocardium.

1983 • 279 citations

Cellular and molecular biology of muscle development

1990 • 248 citations

Genetic complementation reveals a novel regulatory role for 3? untranslated regions in growth and differentiation

1993 • 245 citations

Structure of co-crystals of tropomyosin and troponin

1987 • 242 citations

The functional importance of multiple actin isoforms

1990 • 239 citations

Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.

1991 • 228 citations

Simultaneous expression of skeletal muscle and heart actin proteins in various striated muscle tissues and cells. A quantitative determination of the two actin isoforms.

1986 • 225 citations

Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy.

1992 • 223 citations

Chemical and immunochemical characteristics of tropomyosins from striated and smooth muscle

1974 • 217 citations

Nonmuscle and Muscle Tropomyosin Isoforms Are Expressed from a Single Gene by Alternative RNA Splicing and Polyadenylation

1986 • 190 citations

Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole.

1991 • 180 citations

Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms.

1987 • 174 citations

Molecular and Cell Isoforms During Development

1983 • 172 citations

The Rat α-Tropomyosin Gene Generates a Minimum of Six Different mRNAs Coding for Striated, Smooth, and Nonmuscle Isoforms by Alternative Splicing

1988 • 167 citations

Myosin types in the human heart. An immunofluorescence study of normal and hypertrophied atrial and ventricular myocardium.

1984 • 161 citations

Effect of different troponin T-tropomyosin combinations on thin filament activation

1987 • 161 citations

Genetic dissection of Drosophila myofibril formation: effects of actin and myosin heavy chain null alleles.

1989 • 156 citations

Molecular structure and evolutionary origin of human cardiac muscle actin gene.

1982 • 155 citations

Actin and myosin multigene families: their expression during the formation of skeletal muscle.

1985 • 142 citations

Calcium in Muscle Activation

1988 • 136 citations

Monoclonal Antibodies Against Chicken Tropomyosin Isoforms: Production, Characterization, and Application

1985 • 136 citations

Myosin types and fiber types in cardiac muscle. I. Ventricular myocardium.

1981 • 133 citations

Heterogeneity of contractile proteins. Differences in tropomyosin in fast, mixed, and slow skeletal muscles of the rabbit.

1982 • 129 citations

Alpha-skeletal actin is associated with increased contractility in the mouse heart.

1994 • 128 citations

Developmental analysis of tropomyosin gene expression in embryonic stem cells and mouse embryos.

1993 • 124 citations

Evolution of the human sarcomeric-actin genes: Evidence for units of selection within the 3′ untranslated regions of the mRNAs

1984 • 100 citations

An insertion within a variably spliced Drosophila tropomyosin gene blocks accumulation of only one encoded isoform

1985 • 88 citations

Morphology of developing heart in cardiac lethal mutant Mexican axolotls, Ambystoma mexicanum

1973 • 87 citations

Heterogeneity of contractile proteins. A continuum of troponin-tropomyosin expression in mammalian skeletal muscle.

1985 • 85 citations

Types of troponin components during development of chicken skeletal muscle

1981 • 78 citations

A 40-base-pair sequence in the 3' end of the beta-actin gene regulates beta-actin mRNA transcription during myogenesis.

1988 • 77 citations

Expression of transfected mutant beta-actin genes: alterations of cell morphology and evidence for autoregulation in actin pools.

1987 • 76 citations

Differential control of tropomyosin mRNA levels during myogenesis suggests the existence of an isoform competition-autoregulatory compensation control mechanism

1990 • 73 citations

Transfection of nonmuscle beta- and gamma-actin genes into myoblasts elicits different feedback regulatory responses from endogenous actin genes

1992 • 70 citations

Organization of the hTMnm gene

1988 • 68 citations

Skeletal troponin C reduces contractile sensitivity to acidosis in cardiac myocytes from transgenic mice.

1993 • 67 citations

Expression of Transfected Mutant β-actin Genes: Transitions Toward the Stable Tumorigenic State

1987 • 63 citations

The extent of amino-terminal heterogeneity in rabbit fast skeletal muscle troponin T

1987 • 59 citations

The molecular biology of heart failure

1993 • 58 citations

Comparison of myosin heavy chains in atria and ventricles from hyperthyroid, hypothyroid, and euthyroid rabbits.

1984 • 55 citations

Calcium in muscle activation

1989 • 55 citations

A comparative study of skeletal and cardiac tropomyosins

1976 • 54 citations

Relations between chord and slope conductances and equivalent electromotive forces

1986 • 50 citations

Visualization of cardiac ventricular myosin heavy chain homodimers and heterodimers by monoclonal antibody epitope mapping.

1987 • 46 citations

Identification of transgenic mice carrying the CAT gene with PCR amplification.

1989 • 43 citations

Structure and complete nucleotide sequence of the gene encoding rat fibroblast tropomyosin 4

1990 • 40 citations

Analysis of the crystallization kinetics of lysozyme using a model with polynuclear growth mechanism

1994 • 34 citations

Patterns of troponin T expression in mammalian fast, slow and promiscuous muscle fibres

1987 • 30 citations

Molecular heterogeneity of histochemical fibre types: a comparison of fast fibres

1985 • 26 citations

Transformation and rescue of a flightless Drosophila tropomyosin mutant.

1987 • 25 citations

Modulation of microfilament protein composition by transfected cytoskeletal actin genes.

1988 • 20 citations

Tissue-specific transcriptional control of α- and β-tropomyosins in chicken muscle development

1989 • 19 citations

Angular disorder of weak-binding actomyosin cross-bridges

1994 • 10 citations

Regulation of chicken α and β actin genes and their hybrids inserted into myogenic mouse cells

1989 • 7 citations